ATP citrate lyase (ATP柠檬酸裂解酶)

ACLY (ATP citrate lyase) catalyzes the synthesis of acetyl-CoA from citrate. It is a cytosolic enzyme that involved in fetal growth/development, tumor cell growth/survival and metabolic disorder etc.

Cat.No. 产品名称 Information
GC48923 (±)-Hydroxycitric Acid A hydroxy derivative of citric acid
GC63570 (-)-Hydroxycitric acid lactone (-)-Hydroxycitric acid lactone (Garcinia lactone) 是一种减肥药，也是一种很受欢迎的减肥食品补充剂。(-)-Hydroxycitric acid lactone 是一种有效的 ATP-柠檬酸裂解酶抑制剂。(-)-Hydroxycitric acid lactone 催化柠檬酸盐线粒体外裂解为草酰乙酸和乙酰辅酶 A，限制了脂肪酸合成所需乙酰辅酶 A 单位的可用性。
GC31632 2-Furoic acid (Furan-2-carboxylic acid)
2-Furoic acid (2-Furancarboxylic acid, Pyromucic acid, 2-Carboxyfuran, α-furancarboxylic acid, α-furoic acid) is an organic compound most widely found in food products as a preservative and a flavoring agent.
GC10884 BMS-303141 An ACL inhibitor
GC33760 ETC-1002 (ESP-55016) A prodrug form of ETC-1002-CoA
GC60919 Hydroxycitric acid tripotassium hydrate Hydroxycitricacidtripotassiumhydrate(Potassiumcitratemonohydrate)是藤黄果的主要活性成分，也是柠檬酸的衍生物。Hydroxycitricacidtripotassiumhydrate可竞争性抑制柠檬酸裂解酶(ATPcitratelyase)，并具有减肥效果。Hydroxycitricacidtripotassiumhydrate有效抑制结石形成并抑制HIF，具有抗氧化，抗炎和抗肿瘤作用。
GC38932 NDI-091143 An ACL inhibitor
GC16952 SB 204990 A cell-permeable prodrug of SB 201076