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Thymidylate Synthase(胸苷酸合成酶)

Thymidylate synthase (TS) is an enzyme catalyzing the sole de novo pathway for the biosynthesis of deoxythymidine monophosphate (dTMP) in which deoxyuridine monophosphate (dUMP) is reductively methylated by 5,10-methylenetetrahydrofolate (CH2H4folate) with the generation of dTMP and dihydrofolate (H2folate). TS has been found in a wide range of sources, including bacteria, bacteriophage, yeast, viruses and vertebrates, where it is usually a dimer consisting of identical subunits (30 to 35 kDa each). However, protozoal TS is a bifunctional protein with dihydrofolate reductase (DHFR) on the same polypeptide chain, where TS and DHFR domains are located on the carboxy terminus and amino terminus respectively.

  1. Cat.No. 产品名称 Information
  2. GC64726 10-Formyl-5,8-dideazafolic acid 10-Formyl-5,8-dideazafolic acid 是一种胸苷酸合成酶 (thymidylate synthase) 抑制剂。
  3. GC62645 Fosifloxuridine nafalbenamide Fosifloxuridine nafalbenamide (NUC-3373) 属于嘧啶核苷酸类似物,是一种胸腺嘧啶合酶 (Thymidylate synthase) 抑制剂。Fosifloxuridine nafalbenamide 具有抗癌活性。Fosifloxuridine nafalbenamide 具有诱发宿主免疫反应和增强免疫治疗的潜力。
  4. GC37798 Tipiracil A potent TPase inhibitor
  5. GC19348 TAS-102 An orally bioavailable combination of a nucleoside analog and TPase inhibitor
  6. GC14681 Nolatrexed (AG-337) A thymidylate synthase inhibitor
  7. GC17750 Raltitrexed An inhibitor of thymidylate synthase
  8. GC11099 Doxifluridine An antitumor prodrug of 5-fluorouracil
  9. GC13803 Triflurdine (Viroptic) A thymidine analog that inhibits DNA synthesis
  10. GC17694 Pemetrexed disodium hemipenta hydrate Pemetrexed disodium hemipenta hydrate 是一种新型抗叶酸剂,LY231514 的五谷氨酸的 Ki 值分别为 1.3、7.2 和 65 nM,用于抑制胸苷酸合酶 (TS)、二氢叶酸还原酶 (DHFR) 和甘氨酰胺核糖核苷酸甲酰转移酶 (GARFT)。
  11. GC11610 Pemetrexed An antifolate with anticancer activity

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