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Thymidylate Synthase(胸苷酸合成酶)

Thymidylate synthase (TS) is an enzyme catalyzing the sole de novo pathway for the biosynthesis of deoxythymidine monophosphate (dTMP) in which deoxyuridine monophosphate (dUMP) is reductively methylated by 5,10-methylenetetrahydrofolate (CH2H4folate) with the generation of dTMP and dihydrofolate (H2folate). TS has been found in a wide range of sources, including bacteria, bacteriophage, yeast, viruses and vertebrates, where it is usually a dimer consisting of identical subunits (30 to 35 kDa each). However, protozoal TS is a bifunctional protein with dihydrofolate reductase (DHFR) on the same polypeptide chain, where TS and DHFR domains are located on the carboxy terminus and amino terminus respectively.

Products for  Thymidylate Synthase

  1. Cat.No. 产品名称 Information
  2. GC64726 10-Formyl-5,8-dideazafolic acid 10-Formyl-5,8-dideazafolic acid 是一种胸苷酸合成酶 (thymidylate synthase) 抑制剂。
  3. GC62645 Fosifloxuridine nafalbenamide


    Fosifloxuridine nafalbenamide (NUC-3373) 属于嘧啶核苷酸类似物,是一种胸腺嘧啶合酶 (Thymidylate synthase) 抑制剂。Fosifloxuridine nafalbenamide 具有抗癌活性。Fosifloxuridine nafalbenamide 具有诱发宿主免疫反应和增强免疫治疗的潜力。
  4. GC37798 Tipiracil


    A potent TPase inhibitor
  5. GC19348 TAS-102


    An orally bioavailable combination of a nucleoside analog and TPase inhibitor
  6. GC14681 Nolatrexed (AG-337)

    盐酸诺拉曲塞,AG 337; Thymitaq

    A thymidylate synthase inhibitor
  7. GC17750 Raltitrexed

    雷替曲塞; ZD1694; D1694; ICI-D1694

    An inhibitor of thymidylate synthase
  8. GC11099 Doxifluridine

    去氧氟尿苷; Ro 21-9738; 5-Fluoro-5'-deoxyuridine; 5'-DFUR

    An antitumor prodrug of 5-fluorouracil
  9. GC13803 Triflurdine (Viroptic)

    曲氟尿苷; Trifluorothymidine; 5-Trifluorothymidine; TFT

    A thymidine analog that inhibits DNA synthesis
  10. GC17694 Pemetrexed disodium hemipenta hydrate

    培美曲塞二钠水合物; LY231514 disodium hemipenta hydrate

    Pemetrexed disodium hemipenta hydrate 是一种新型抗叶酸剂,LY231514 的五谷氨酸的 Ki 值分别为 1.3、7.2 和 65 nM,用于抑制胸苷酸合酶 (TS)、二氢叶酸还原酶 (DHFR) 和甘氨酰胺核糖核苷酸甲酰转移酶 (GARFT)。
  11. GC11610 Pemetrexed

    培美曲塞二钠盐; LY231514 disodium

    An antifolate with anticancer activity

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