Bcl-xL
BCL-XL (B-cell lymphoma-extra large), an anti-apoptotic member of the BCL-2 family proteins, is prominently found in the inner membrane of mitochondria and characterized by containing all four BCL-2 homology (BH) domains (BH1 to BH4). A hydrophobic cleft (the BH3-binding groove) formed by apposition of the BH1, BH2 and BH3 domains has been identified in the molecular surface of BCL-XL, through which it interacts with pro-apoptotic BCL-2 proteins, Bax and Bak, to inhibit apoptosis. Moreover, BCL-XL also exhibits anti-autophagy abilities to avoid autophagic cell death by binding to protein Beclin 1, which is required to initiate the formation of autophagasome in autophagy.
- Cat.No. 产品名称 Information
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GC17512
A-1155463
A Bcl-xL inhibitor
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GC17513
A-1331852
A Bcl-xL inhibitor
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GC17234
ABT-737
An inhibitor of anti-apoptotic Bcl-2 proteins
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GC12139
Gambogic Acid
A xanthonoid with anticancer activity
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GC11510
HA14-1
A Bcl-2 inhibitor
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GC12649
TW-37
An inhibitor of the Bcl-2 family proteins
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GC11921
WEHI-539
A selective Bcl-xL inhibitor
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GC13317
WEHI-539 hydrochloride
A selective Bcl-xL inhibitor