Home >> Signaling Pathways >> Apoptosis >> Bcl-xL


BCL-XL (B-cell lymphoma-extra large), an anti-apoptotic member of the BCL-2 family proteins, is prominently found in the inner membrane of mitochondria and characterized by containing all four BCL-2 homology (BH) domains (BH1 to BH4). A hydrophobic cleft (the BH3-binding groove) formed by apposition of the BH1, BH2 and BH3 domains has been identified in the molecular surface of BCL-XL, through which it interacts with pro-apoptotic BCL-2 proteins, Bax and Bak, to inhibit apoptosis. Moreover, BCL-XL also exhibits anti-autophagy abilities to avoid autophagic cell death by binding to protein Beclin 1, which is required to initiate the formation of autophagasome in autophagy.

Products for  Bcl-xL

  1. Cat.No. 产品名称 Information
  2. GC17512 A-1155463 A Bcl-xL inhibitor
  3. GC17513 A-1331852 A Bcl-xL inhibitor
  4. GC17234 ABT-737 An inhibitor of anti-apoptotic Bcl-2 proteins
  5. GC12139 Gambogic Acid A xanthonoid with anticancer activity
  6. GC11510 HA14-1 A Bcl-2 inhibitor
  7. GC12649 TW-37 An inhibitor of the Bcl-2 family proteins
  8. GC11921 WEHI-539 A selective Bcl-xL inhibitor
  9. GC13317 WEHI-539 hydrochloride A selective Bcl-xL inhibitor

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