Hydroxyphenyllactic acid
(Synonyms: 3-(4-羟基苯基)乳酸) 目录号 : GC33991
Hydroxyphenyllactic acid是一种酪氨酸代谢物。
Cas No.:306-23-0
Sample solution is provided at 25 µL, 10mM.
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Hydroxyphenyllactic acid is a tyrosine metabolite [1]. Hydroxyphenyllactic acid inhibits the production of reactive oxygen species (ROS) in mitochondria and neutrophils, thereby exerting a natural antioxidant effect [2]. Hydroxyphenyllactic acid is primarily used to treat fungi [3-4].
In AML-12 cells, Hydroxyphenyllactic acid (0.1μg/mL, 0.5μg/mL; 24h) treatment protects against ethanol-induced damage [5].
In C57BL/6 mice, Hydroxyphenyllactic acid (42mg; sc; 30d) has embryogenic activity [6].
References:
[1]. Mu W, Yu S, Zhu L, et al. Production of 3-phenyllactic acid and 4-hydroxyphenyllactic acid by Pediococcus acidilactici DSM 20284 fermentation[J]. European Food Research and Technology, 2012, 235(3): 581-585.
[2]. Beloborodova N, Bairamov I, Olenin A, et al. Effect of phenolic acids of microbial origin on production of reactive oxygen species in mitochondria and neutrophils[J]. Journal of biomedical science, 2012, 19(1): 89.
[3]. Lunavath R, Mohammad S H, Bhukya K K, et al. Antimycotic effect of 3-phenyllactic acid produced by probiotic bacterial isolates against Covid-19 associated mucormycosis causing fungi[J]. PLoS One, 2023, 18(3): e0279118.
[4]. Li C, Deng Y, Wang J, et al. Effects of p-hydroxyphenylacetic acid and p-hydroxybenzoic acid on soil bacterial and fungal communities[J]. Sustainability, 2023, 15(12): 9285.
[5]. Zhang C, Chen Y, Huang S, et al. 3, 4-hydroxyphenyl lactic acid from Lactiplantibacillus plantarum prevents alcoholic liver injury in mice[J]. bioRxiv, 2025: 2025.03. 12.642873.
[6]. Rauschenbach M O, Zharova E I, Sergeeva T I, et al. Blastomogenic activity of p-hydroxyphenyllactic acid in mice[J]. Cancer research, 1975, 35(3): 577-585.
Hydroxyphenyllactic acid是一种酪氨酸代谢物 [1]。Hydroxyphenyllactic acid能抑制线粒体和中性粒细胞中活性氧（ROS）的产生，从而发挥天然抗氧化作用 [2]。羟苯乳酸主要用于治疗真菌 [3-4]。
在AML-12细胞中，Hydroxyphenyllactic acid（0.1μg/mL，0.5μg/mL；24h）治疗可防止乙醇引起的损伤 [5]。
在C57BL/6小鼠中，Hydroxyphenyllactic acid （42mg；sc：30d）具有胚胎致胚活性 [6]。
| Cell experiment [1]: | |
Cell lines | AML-12 cells |
Preparation Method | To investigate the protective effect of Hydroxyphenyllactic acid on ethanol-damaged AML-12 cells, the cells were divided into control, model, and experimental groups. AML-12 cells (2×105 cells/well) were incubated in six-well plates for 24 hours. Fresh medium was replaced with medium containing different concentrations of Hydroxyphenyllactic acid (0.1μg/mL and 0.5μg/mL) and incubated for an additional 24 hours. Subsequently, medium containing varying concentrations of ethanol was added, and the cells were incubated for an additional 24 hours before conducting subsequent experiments. |
Reaction Conditions | 0.1μg/mL, 0.5μg/mL; 24h |
Applications | Hydroxyphenyllactic acid treatment protects against ethanol-induced damage. |
| Animal experiment [2]: | |
Animal models | C57BL/6 mice |
Preparation Method | Six-week-old male and female non-inbred C57BL/6 mice were used. These mice were kept in an isolator animal housing facility, 10 per metal cage. All experimental and control groups were fed a standard diet and had free access to water. The metabolite was dissolved in distilled water at a concentration of 10mg/mL. Each mouse received 2.5mg of the metabolite dissolved in 0.25mL of water and injected subcutaneously into the back twice weekly. The total dose of Hydroxyphenyllactic acid was 42mg (233μmol) per mouse, and the total dose of phenyllactic acid was 50mg (301μmol) per mouse. |
Dosage form | 42mg; sc; 30d |
Applications | Hydroxyphenyllactic acid has embryogenic activity. |
References: | |
| Cas No. | 306-23-0 | SDF | |
| 别名 | 3-(4-羟基苯基)乳酸 | ||
| Canonical SMILES | O=C(O)C(O)CC1=CC=C(O)C=C1 | ||
| 分子式 | C9H10O4 | 分子量 | 182.17 |
| 溶解度 | DMSO : 125 mg/mL (686.17 mM) | 储存条件 | 4°C, away from moisture and light |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 5.4894 mL | 27.4469 mL | 54.8938 mL |
| 5 mM | 1.0979 mL | 5.4894 mL | 10.9788 mL |
| 10 mM | 0.5489 mL | 2.7447 mL | 5.4894 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >98.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet