2-Phenylethanol
(Synonyms: 苯乙醇; Phenylethyl alcohol; Phenethyl alcohol; Benzyl carbinol) 目录号 : GC60484
2-Phenylethanol是一种重要的芳香醇，具有类似玫瑰的香气。
Cas No.:60-12-8
Sample solution is provided at 25 µL, 10mM.
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2-Phenylethanol is an important aromatic alcohol with a rose-like aroma [1].2-Phenylethanol has anti-tyrosinase and antibacterial activities [2]. 2-Phenylethanol is used in the food, flavor and cosmetic industries [3].
In F. graminearum, 2-Phenylethanol (0.6mg/mL, 1.2mg/mL, 2.4mg/mL; 14d) exhibited excellent inhibition of the mycelial growth of F. graminearum with the EC50 value at 0.328mg/mL [4]. In A. hydrophila, 2-Phenylethanol (1mg/mL; 24h) significantly inhibited A. hydrophila biofilm formation [5].
In C57BL/6 mice, inhalation of rose oil containing 2-Phenylethanol (2mL of 5% 2-Phenylethanol; inhalation; 15min) may be effective against depression and stress-related diseases [6]. In pregnant Long‐Evans rats, noteworthy dose-related teratogenic effects of 2-Phenylethanol (4.3mg/kg, 43mg/kg, 430mg/kg; po; 9d) in offspring manifested themselves in increased incidences of malformed eyes, neural‐tube defects, hydronephrosis, and limb defects [7]. In C57BL/6 mice, 2-Phenylethanol (2mL of 0.08% 2-Phenylethanol; inhalation; 2 hour a day for 7 days) modulates hippocampal endocannabinoid signaling to reduce anxiety-like behavioral defects in mice [8].
References:
[1]. Hua D, Xu P. Recent advances in biotechnological production of 2-phenylethanol. Biotechnology advances. 2011 Nov 1; 29(6): 654-1660.
[2]. Zhu YJ, Zhou HT, Hu YH, et al. Antityrosinase and antimicrobial activities of 2-phenylethanol, 2-phenylacetaldehyde and 2-phenylacetic acid. Food Chemistry. 2011 Jan 1; 124(1): 298-302..
[3]. Chreptowicz K, Wielechowska M, Głowczyk-Zubek J, et al. Production of natural 2-phenylethanol: from biotransformation to purified product. Food and Bioproducts Processing. 2016 Oct 1; 100: 275-281.
[4]. Sun S, Tang N, Han K, et al. Effects of 2-phenylethanol on controlling the development of Fusarium graminearum in wheat. Microorganisms. 2023 Dec 10; 11(12): 2954.
[5]. Yin LJ, Wang W, Wang M, et al. 2-Phenylethanol in Endophytes of Areca catechu L. Inhibits the Biofilms and Virulence Against Aeromonas hydrophila. World Journal of Traditional Chinese Medicine. 2025: 10-4103.
[6]. Ueno H, Shimada A, Suemitsu S, et al. Anti-depressive-like effect of 2-phenylethanol inhalation in mice. Biomedicine & pharmacotherapy. 2019 Mar 1; 111: 1499-1506.
[7]. Mankes RF, LeFevre R, Bates H, et al. Effects of various exposure levels of 2‐phenylethanol on fetal development and survival in long‐Evans Rats. Journal of Toxicology and Environmental Health, Part A Current Issues. 1983 Aug 1; 12(2-3): 235-244.
[8]. Bi JR, Zha HW, Gao QL, et al. Pleasant Odor Decreases Mouse Anxiety-like Behaviors by Regulating Hippocampal Endocannabinoid Signaling. International Journal of Molecular Sciences. 2024 Oct 4; 25(19): 10699.
2-Phenylethanol是一种重要的芳香醇，具有类似玫瑰的香气 [1]。2-Phenylethanol具有抗酪氨酸酶和抗菌活性 [2]。2-Phenylethanol用于食品、香料和化妆品行业 [3]。
在禾谷镰刀菌中，2-Phenylethanol（0.6mg/mL、1.2mg/mL、2.4mg/mL；14d）表现出对禾谷镰刀菌菌丝生长的优异抑制作用，EC50值为0.328mg/mL [4]。在嗜水气单胞菌中，2-Phenylethanol（1mg/mL；24h）显著抑制了嗜水气单胞菌生物膜的形成 [5]。
在C57BL/6小鼠中，吸入含有2-Phenylethanol的玫瑰油（2mL 5% 2-Phenylethanol；吸入；15分钟）可能对抑郁症和应激相关疾病有效 [6]。在怀孕的Long-Evans大鼠中，2-Phenylethanol（4.3mg/kg、43 mg/kg、430mg/kg；po；9d）对后代有显著的剂量相关性致畸作用，表现为眼畸形、神经管缺陷、肾积水和肢体缺陷发生率增加 [7]。在C57BL/6小鼠中，2-Phenylethanol（2mL 0.08% 2-Phenylethanol；吸入；每天2小时，持续7天）可调节海马内源性大麻素信号，从而减少小鼠的焦虑样行为缺陷 [8]。
| Antibacterial experiment [1]: | |
Bacteria | F. graminearum |
Preparation Method | Field efficacy experiments of 2-Phenylethanol against F. graminearum on wheat spikes were conducted. At the anthesis stage, the spikes were inoculated with 10µL spore suspension (5 × 105spores/mL) of F. graminearum. The wheat spikes (Fielder, susceptible to FHB) were evenly sprayed with 2-Phenylethanol diluted in water to different final concentrations (0.6mg/mL, 1.2mg/mL, 2.4mg/mL). The same amount of water was set as a negative control (CK) and tebuconazole (215μg/mL) as a positive control (CK1). |
Reaction Conditions | 0.6mg/mL, 1.2mg/mL, 2.4mg/mL; 14d |
Applications | 2-Phenylethanol exhibited excellent inhibition of the mycelial growth of F. graminearum with the EC50 value at 0.328mg/mL. |
| Animal experiment [2]: | |
Animal models | C57BL/6 mice |
Preparation Method | A piece of absorbent cotton (4 × 4cm2) impregnated with 2mL of 5% 2-Phenylethanol was placed in a stainless steel container (60 × 60 × 35mm3) capped by a lid with holes. The mice were unable to lick or touch the cotton. The stainless steel container was placed in a new breeding cage (235 × 325 × 170mm3) surrounded by two larger cages (292 × 440 × 200mm3). Approximately 15min after the cotton placement, the mice were placed in the internal cage for 15min. The inhalation was started before 20min all behavioral tests. 2-Phenylethanol was diluted in 1% Tween 80 (v/v) to obtain a concentration of 5% (v/v). |
Dosage form | 2mL of 5% 2-Phenylethanol; inhalation; 15min |
Applications | Inhalation of rose oil containing 2-Phenylethanol may be effective against depression and stress-related diseases. |
References: | |
| Cas No. | 60-12-8 | SDF | |
| 别名 | 苯乙醇; Phenylethyl alcohol; Phenethyl alcohol; Benzyl carbinol | ||
| Canonical SMILES | OCCC1=CC=CC=C1 | ||
| 分子式 | C8H10O | 分子量 | 122.16 |
| 溶解度 | Water: 20 mg/mL (163.72 mM) | 储存条件 | Store at -20°C,protect from light |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 8.186 mL | 40.9299 mL | 81.8599 mL |
| 5 mM | 1.6372 mL | 8.186 mL | 16.372 mL |
| 10 mM | 0.8186 mL | 4.093 mL | 8.186 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet