Bovinic acid
(Synonyms: 共轭(9Z11E)亚油酸,Bovinic acid; 9Z,11E-CLA; Rumenic Acid) 目录号 : GC31626
Bovinic acid是一种共轭亚油酸，是一种在天然食物（特别是反刍动物制品）中存在的十八碳二烯酸。
Cas No.:2540-56-9
Sample solution is provided at 25 µL, 10mM.
Bovinic acid is a conjugated linoleic acid, an octadecadienoic acid found in natural foods, particularly ruminant products[1]. Bovinic acid is a potential bioactive component with activities such as anti-oxidative stress, anti-cancer, anti-diabetic, and anti-atherosclerotic effects[2, 3, 4]. Adding Bovinic acid to milk has a protective effect on colitis mice by activating the colonic nuclear factor-associated factor 2 (Nrf2) pathway[5].
In vivo, oral administration of Bovinic acid (100mg/kg) to mice with alcoholic liver disease (ALD) for 10 days significantly reduced serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, decreased malondialdehyde (MDA) levels in liver tissue, and improved liver morphology[4].
References:
[1] Indu B, Jayaprakasha H M. Conjugated Linoleic Acid-The Natural Trans Fat: A Review[J]. Asian Journal of Dairy & Food Research, 2021, 40(4).
[2] Lock A L, Bauman D E. Modifying milk fat composition of dairy cows to enhance fatty acids beneficial to human health[J]. Lipids, 2004, 39(12): 1197-1206.
[3] Ayadi M, Hammadi M, Casals R, et al. Influence of management type and stage of lactation on the performance and milk fatty acid profile of dairy camels (Camelus dromedaries)[J]. The Journal of Agricultural Science, 2018, 156(9): 1111-1122.
[4] Dong Z, Zhang Z, Peng Y, et al. Pien Tze Huang ameliorates alcohol-associated liver disease by suppressing oxidative stress and ferroptosis through bovinic acid and taurine[J]. Beizi and Zhao, Mingrui and Gong, Maosheng and Wang, Guangji and Aa, Jiye and Hao, Haiping and Wang, Hong, Pien Tze Huang ameliorates alcohol-associated liver disease by suppressing oxidative stress and ferroptosis through bovinic acid and taurine.
[5] Bergamo P, Cocca E, Monaco A, et al. Protective effect of Rumenic acid rich cow's milk against colitis is associated with the activation of Nrf2 pathway in a murine model[J]. Prostaglandins, Leukotrienes and Essential Fatty Acids, 2017, 125: 14-23.
Bovinic acid是一种共轭亚油酸，是一种在天然食物（特别是反刍动物制品）中存在的十八碳二烯酸[1]。Bovinic acid是潜在的生物活性成分，具有抗氧化应激、抗癌、抗糖尿病和抗动脉硬化等活性[2, 3, 4]。在牛奶中加入Bovinic acid对结肠炎小鼠具有保护作用，激活了结肠核因子相关因子2（Nrf2）通路[5]。
在体内，Bovinic acid（100mg/kg）通过口服治疗酒精性肝病（ALD）小鼠10天，显著降低了小鼠血清中丙氨酸氨基转移酶（ALT）和天冬氨酸氨基转移酶（AST）的水平，降低了肝脏组织中丙二醛（MDA）的水平，改善了肝组织形态[4]。
| Animal experiment [1]: | |
Animal models | C57BL/6J mice |
Preparation Method | Mice were randomly divided into five groups: control, model, taurine (200mg/kg), Bovinic acid (BA, 100mg/kg), and taurine+BA (200 and 100mg/kg, respectively). Taurine, BA, or their combination were administered via intragastric gavage once daily for 10 days. Control and model groups received an equivalent volume of vehicle. |
Dosage form | 100mg/kg; 10 days; p.o. |
Applications | Ethanol administration led to elevated serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels in mice, while Bovinic acid, taurine, or a combination of both significantly reduced ALT and AST levels. Furthermore, combination therapy showed the most significant effect. |
References: | |
| Cas No. | 2540-56-9 | SDF | |
| 别名 | 共轭(9Z11E)亚油酸,Bovinic acid; 9Z,11E-CLA; Rumenic Acid | ||
| 化学名 | 9Z,11E-octadecadienoic acid | ||
| Canonical SMILES | CCCCCC/C=C/C=C\CCCCCCCC(O)=O | ||
| 分子式 | C18H32O2 | 分子量 | 280.45 |
| 溶解度 | 100mg/mL in DMSO & DMF | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.5657 mL | 17.8285 mL | 35.657 mL |
| 5 mM | 713.1 μL | 3.5657 mL | 7.1314 mL |
| 10 mM | 356.6 μL | 1.7828 mL | 3.5657 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet