2-(2-Phenylethyl)chromone
(Synonyms: 2-(2-苯乙基)色酮,Flidersiachromone) 目录号 : GC19560
2-(2-Phenylethyl)chromone是沉香的主要活性成分，具有多种药理作用，包括抗炎、抗癌、神经保护、抗氧化及乙酰胆碱酯酶抑制活性。
Cas No.:61828-53-3
Sample solution is provided at 25 µL, 10mM.
2-(2-Phenylethyl)chromone is the main bioactive component of agarwood which showed diverse pharmaceutical activities, such as anti-inflammatory activity, anticancer activity, neuroprotective activity, antioxidant activity, acetylcholinesterase inhibition activity[1].
In vitro, 2-(2-Phenylethyl)chromone (10, 50 and100μg/mL; 24h) inhibits oxLDL uptake of macrophages[2]. 2-(2-Phenylethyl)chromone (5 and 10μg/mL; 24h) significantly inhibits TCA-induced apoptosis in GES-1 cells by suppressing the PERK/eIF2α/CHOP pathway[3].
In vivo, 2-(2-Phenylethyl)chromone (50 and 100mg/kg; 6 weeks; p.o.) effectively reduces the formation of aortic plaques in atherosclerotic ApoE mice[2]. 2-(2-Phenylethyl)chromone (20 and 40mg/kg; 7 days; p.o.) reduced the gastric occurrence and ulcer inhibition rates by up to more than 70% in a dose-dependent manner[4].
References:
[1] Wang Y, Huang W, Tian W, Mo T, Yan Y, Cui X, Liu X. Enzymatic biosynthesis of novel 2-(2-phenylethyl)chromone glycosides catalyzed by UDP-glycosyltransferase UGT71BD1. Biochem Biophys Res Commun. 2023 Sep 3;671:80-86.
[2] Ma J, Wang L, Zhao Y, Gao Y, Yin Z, Zhao M, Zhao Y, Pang X, Wang J, Xue W, Tu P, Li J, Zheng J. 2-(2-Phenylethyl)chromone-enriched extract of Chinese agarwood (Aquilaria sinensis) inhibits atherosclerosis progression through endoplasmic reticulum stress-mediated CD36 expression in macrophages. J Ethnopharmacol. 2024 Feb 10;320:117411.
[3] Ma J, Huo H, Zhang H, Wang L, Meng Y, Jin F, Wang X, Zhao Y, Zhao Y, Tu P, Song Y, Zheng J, Li J. 2-(2-phenylethyl)chromone-enriched extract of the resinous heartwood of Chinese agarwood (Aquilaria sinensis) protects against taurocholic acid-induced gastric epithelial cells apoptosis through Perk/eIF2α/CHOP pathway. Phytomedicine. 2022 Apr;98:153935.
[4] Wang C, Wu Y, Gong B, Mou J, Cheng X, Zhang L, Wei J. Agarwood Chromone Alleviates Gastric Ulcers by Inhibiting the NF-κB and Caspase Pathways Based on Network Pharmacology and Molecular Docking. Pharmaceuticals (Basel). 2025 Mar 31;18(4):514.
2-(2-Phenylethyl)chromone是沉香的主要活性成分，具有多种药理作用，包括抗炎、抗癌、神经保护、抗氧化及乙酰胆碱酯酶抑制活性[1]。
在体外：2-(2-Phenylethyl)chromone (10, 50和100μg/mL; 24h)可抑制巨噬细胞对氧化低密度脂蛋白(oxLDL)的摄取[2]。2-(2-Phenylethyl)chromone (5和10μg/mL; 24h)通过抑制PERK/eIF2α/CHOP通路，显著减少TCA诱导的GES-1细胞凋亡[3]。
在体内：2-(2-Phenylethyl)chromone (50和100mg/kg; 6周; 口服)可有效减少动脉粥样硬化ApoE小鼠主动脉斑块的形成[2]。2-(2-Phenylethyl)chromone (20和40mg/kg; 7天; 口服)以剂量依赖方式使胃溃疡发生率降低、溃疡抑制率提高至70%以上[4]。
| Cell experiment [1]: | |
Cell lines | GES-1 |
Preparation Method | GES-1 cells were co-incubated with 1.5mM TCA and 5 or 10μg/mL 2-(2-phenylethyl)chromone for 24h, stained with an Annexin V-FITC kit, fixed, and then analyzed by FACS. The Q4 quadrant denotes early apoptosis, and the Q2 quadrant denotes late apoptosis. |
Reaction Conditions | 5 and 10μg/mL; 24h |
Applications | 2-(2-Phenylethyl)chromone significantly inhibits TCA-induced apoptosis in GES-1 cells by suppressing the PERK/eIF2α/CHOP pathway. |
| Animal experiment [2]: | |
Animal models | Male ICR mice |
Preparation Method | Seventy mice were randomly divided into seven groups. The groups were as follows: normal control group, model group, OEC group (positive control), 2-(2-Phenylethyl)chromone group. The normal and model groups were orally administered 20mL/kg of distilled water. The OEC group was pretreated with 40mg/kg daily via oral garage. The 2-(2-Phenylethyl)chromone was administered at 20 and 40mg/kg doses. After pretreatment for 7 days and 12h of food deprivation with water ad libitum, the other mice were used to develop an acute gastric ulcer model by administering absolute ethanol at a concentration of 0.15mL/10g via oral gavage. The normal group was excluded. Whole blood samples were collected from the orbit for serum analysis 1h after the administration of absolute ethanol, and the animals were then sacrificed via cervical dislocation. Their stomachs were immediately removed, fixed with a formaldehyde solution, and prepared for the determination of the gastric lesion index, histopathological sections, and immunohistochemical analysis. |
Dosage form | 20 and 40mg/kg; 7 days; p.o. |
Applications | 2-(2-Phenylethyl)chromone reduced the gastric occurrence and ulcer inhibition rates by up to more than 70% in a dose-dependent manner. |
References: | |
| Cas No. | 61828-53-3 | SDF | |
| 别名 | 2-(2-苯乙基)色酮,Flidersiachromone | ||
| 分子式 | C17H14O2 | 分子量 | 250.29 |
| 溶解度 | DMSO: ≥80mg/ml | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.9954 mL | 19.9768 mL | 39.9537 mL |
| 5 mM | 0.7991 mL | 3.9954 mL | 7.9907 mL |
| 10 mM | 0.3995 mL | 1.9977 mL | 3.9954 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet