Prostaglandin D2-d9

Prostaglandin D₂-d₉ (PGD₂-d₉) contains nine deuterium atoms at the 17, 17', 18, 18', 19, 19', 20, 20, and 20 positions. It is intended for use as an internal standard for the quantification of PGD₂ by GC- or LC-mass spectrometry. PGD₂ is the major eicosanoid product of mast cells and is released in large quantities during allergic and asthmatic anaphylaxis.¹ Mastocytosis patients produce excessive amounts of PGD₂, which causes vasodilation, flushing, hypotension, and syncopal episodes.¹ PGD₂ is also produced in the brain via an alternative pathway involving a soluble, secreted PGD-synthase also known as β-trace.^2,3 In the brain, PGD₂ produces normal physiological sleep and lowering of body temperature.^2,3 Further pharmacological actions include inhibition of platelet aggregation and relaxation of vascular smooth muscle.⁴ PGD₂ inhibits human ovarian tumor cell proliferation with an IC₅₀ value of 6.8 µM.⁵

1.Roberts, L.J., II, and Sweetman, B.J.Metabolic fate of endogenously synthesized prostaglandin D2 in a human female with mastocytosisProstaglandins30(3)383-400(1985) 2.Hayaishi, O.Sleep-wake regulation by prostaglandins D2 and E2J. Biol. Chem.263(29)14593-14596(1988) 3.Onoe, H., Ueno, R., Fujita, I., et al.Prostaglandin D2, a cerebral sleep-inducing substance in monkeysProc. Natl. Acad. Sci. U.S.A.85(11)4082-4086(1988) 4.Giles, H., and Leff, P.The biology and pharmacology of PGD2Prostaglandins35(2)277-300(1988) 5.Kikuchi, Y., Kita, T., Hirata, J., et al.Preclinical studies of antitumor prostaglandins by using human ovarian cancer cellsCancer Metastasis Rev.13(3-4)309-315(1994)