Pregnanediol
(Synonyms: 孕二醇; NSC 1612; NSC 47462) 目录号 : GC39185
Pregnanediol是孕酮的主要代谢产物，通过尿液排出体外。
Cas No.:80-92-2
Sample solution is provided at 25 µL, 10mM.
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Pregnanediol is the main metabolite of progesterone and is excreted in the urine [1]. The Pregnanediol excreted by pregnant women can reflect the function of the placenta, and urine progesterone can be used to assess the function of the ovaries [2]. Pregnanediol can be used as a reference substance to develop new detection methods for improving the identification of related compounds[3]. When zebrafish embryos were exposed to waste water containing 300ng/l Pregnanediol for 48 hours, the spontaneous muscle contraction frequency significantly decreased, and the heart rate of the embryos significantly reduced[4].
References:
[1] Usuki S, Kondoh K, Kubo T. Plasma endothelin and LH-RH, LH, FSH, prolactin, progesterone, 17α-hydroxyprogesterone, estrone, 17β-estradiol, Δ4-androstenedione, testosterone, active renin, angiotensin-II and ANP levels in blood and LH, estrone and 17β-estradiol and pregnanediol levels in urine of normal cycling women[J]. Journal of Cardiovascular Pharmacology, 2000, 36: S421-S427.
[2] Haran S, Chindera K, Sabry M, et al. Natural Killer Cell Dysfunction in Premenopausal BRCA1 Mutation Carriers: A Potential Mechanism for Ovarian Carcinogenesis[J]. Cancers, 2024, 16(6): 1186.
[3] Zhang K, Fent K. Determination of two progestin metabolites (17α-hydroxypregnanolone and pregnanediol) and different classes of steroids (androgens, estrogens, corticosteroids, progestins) in rivers and wastewaters by high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS)[J]. Science of the Total Environment, 2018, 610: 1164-1172.
[4] Zhang K, Zhao Y, Fent K. Occurrence and ecotoxicological effects of free, conjugated, and halogenated steroids including 17α-hydroxypregnanolone and pregnanediol in Swiss wastewater and surface water[J]. Environmental science & technology, 2017, 51(11): 6498-6506.
Pregnanediol是孕酮的主要代谢产物，通过尿液排出体外[1]。孕妇排泄的Pregnanediol可反映胎盘功能，而尿液中Pregnanediol的检测可用于评估卵巢功能[2]。Pregnanediol可作为参照物，用于开发新的检测方法以提升相关化合物的鉴定能力[3]。当斑马鱼胚胎在含有300ng/l Pregnanediol的废水中暴露48小时后，自发性肌肉收缩频率显著降低，同时胚胎心率明显减慢[4]。
| Cas No. | 80-92-2 | SDF | |
| 别名 | 孕二醇; NSC 1612; NSC 47462 | ||
| Canonical SMILES | C[C@@]12[C@]3([H])[C@](CC[C@]1([H])C[C@H](O)CC2)([H])[C@@]4([H])[C@@](C)([C@]([C@@H](O)C)([H])CC4)CC3 | ||
| 分子式 | C21H36O2 | 分子量 | 320.51 |
| 溶解度 | Ethanol: 5 mg/mL (15.60 mM); DMSO: 2 mg/mL (6.24 mM); Water: < 0.1 mg/mL (insoluble) | 储存条件 | Store at RT |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.12 mL | 15.6001 mL | 31.2003 mL |
| 5 mM | 624 μL | 3.12 mL | 6.2401 mL |
| 10 mM | 312 μL | 1.56 mL | 3.12 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet