Podophyllol
(Synonyms: 鬼臼毒醇) 目录号 : GC61195Podophyllol是podophyllotoxin的衍生物,具有抗肿瘤活性。
Cas No.:78339-51-2
Sample solution is provided at 25 µL, 10mM.
Quality Control & SDS
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- Purity: >98.00%
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Podophyllol, a derivative of podophyllotoxin esters, has antitumor activity[1].
[1]. Levy RK, et, al. Antitumor agents LXII: synthesis and biological evaluation of podophyllotoxin esters and related derivatives. J Pharm Sci. 1983 Oct; 72(10): 1158-61.
Cas No. | 78339-51-2 | SDF | |
别名 | 鬼臼毒醇 | ||
Canonical SMILES | OC[C@H]1[C@H](CO)[C@H](C2=CC(OC)=C(OC)C(OC)=C2)C3=C(C=C4OCOC4=C3)[C@@H]1O | ||
分子式 | C22H26O8 | 分子量 | 418.44 |
溶解度 | 储存条件 | Store at -20°C | |
General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。 为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。 |
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1 mg | 5 mg | 10 mg | |
1 mM | 2.3898 mL | 11.9491 mL | 23.8983 mL |
5 mM | 0.478 mL | 2.3898 mL | 4.7797 mL |
10 mM | 0.239 mL | 1.1949 mL | 2.3898 mL |
第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量) | ||||||||||
给药剂量 | mg/kg | 动物平均体重 | g | 每只动物给药体积 | ul | 动物数量 | 只 | |||
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% DMSO % % Tween 80 % saline | ||||||||||
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工作液浓度: mg/ml;
DMSO母液配制方法: mg 药物溶于 μL DMSO溶液(母液浓度 mg/mL,
体内配方配制方法:取 μL DMSO母液,加入 μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入 μL saline,混匀澄清。
1. 首先保证母液是澄清的;
2.
一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。
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Antitumor agents LXII: synthesis and biological evaluation of podophyllotoxin esters and related derivatives
J Pharm Sci 1983 Oct;72(10):1158-61.PMID:6644563DOI:10.1002/jps.2600721012
Synthetic esters of the C-4 hydroxyl group of podophyllotoxin (I) were prepared. In addition, esters were synthesized using the diol system of tetrahydropyranyl Podophyllol (XV), produced by reducing the lactone ring of tetrahydropyranyl podophyllotoxin with lithium aluminum hydride. Six compounds, the acrylate (IV), 3,3-dimethyl acrylate (V), phenoxyacetate (IX), and ethyl adipate (XI) of I as well as Podophyllol (XIV) and tetrahydropyranyl Podophyllol dimesylate (XVIII), showed significant activity when tested using the P-388 lymphocytic leukemia screen at 3 mg/kg/day. None of the esters showed higher activity than that shown by the parent molecule I when tested at the same dosage level.