Picoxystrobin
(Synonyms: 啶氧菌酯) 目录号 : GC62158
Picoxystrobin 是一种主要的 strobilurin 杀菌剂，已广泛用于控制植物病害。Picoxystrobin 可以通过阻止细胞色素 b 和 c1 的 Qo 中心的电子转移来抑制线粒体呼吸。
Cas No.:117428-22-5
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Picoxystrobin is a primary strobilurin fungicide that is widely applied for plant disease control. Picoxystrobin inhibits mitochondrial respiration via blocking electron transfer at the Qo center of cytochrome b and c1[1].
[1]. Wei Jia, et al. Effects of two strobilurins (azoxystrobin and picoxystrobin) on embryonic development and enzyme activities in juveniles and adult fish livers of zebrafish (Danio rerio). Chemosphere. 2018 Sep;207:573-580.
| Cas No. | 117428-22-5 | SDF | |
| 别名 | 啶氧菌酯 | ||
| 分子式 | C18H16F3NO4 | 分子量 | 367.32 |
| 溶解度 | DMSO : 100 mg/mL (272.24 mM; Need ultrasonic) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.7224 mL | 13.6121 mL | 27.2242 mL |
| 5 mM | 0.5445 mL | 2.7224 mL | 5.4448 mL |
| 10 mM | 0.2722 mL | 1.3612 mL | 2.7224 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Residue dissipation, transfer and safety evaluation of Picoxystrobin during tea growing and brewing
J Sci Food Agric 2021 Jan 15;101(1):194-204.PMID:32623719DOI:10.1002/jsfa.10631.
Background: Picoxystrobin is a new osmotic and systemic broad-spectrum methoxyacrylate fungicide with a good control effect on tea anthracnose, so it has been proposed to spray Picoxystrobin before the occurrence and onset of tea anthracnose during tea bud growth in order to protect them. However, there are few reports about the residue analysis method, field dissipation, terminal residue and risk assessment of Picoxystrobin in tea. And there is no scientific and reasonable maximum residue limit of Picoxystrobin in green tea. Results: A rapid and sensitive analysis method for Picoxystrobin residue in fresh tea leaf, green tea, tea infusion and soil was established by UPLC-MS/MS. The spiked recoveries of Picoxystrobin ranged from 73.1% to 111.0%, with relative standard deviations from 1.8% to 9.2%. The limits of quantitation were 20 μg kg-1 in green tea, 8 μg kg-1 in fresh tea leaves and soil and 0.16 μg kg-1 in tea infusion. The dissipation half-lives of Picoxystrobin in fresh tea leaf and soil were 2.7-6.8 and 2.5-14.4 days, respectively. And the maximum residue of Picoxystrobin in green tea was 15.28 mg kg-1 with PHI at 10 days for terminal test. The total leaching rate of Picoxystrobin during green tea brewing was lower than 35.8%. Conclusions: According to safety evaluation, the RQc and RQa values of Picoxystrobin in tea after 5 to 14 days for the last application were significantly lower than 1. Therefore, the maximum residue limit value of Picoxystrobin in tea that we suggest to set at 20 mg kg-1 can ensure the safety of tea for human drinking. © 2020 Society of Chemical Industry.
Magnitude of Picoxystrobin residues in strawberry under Egyptian conditions: dissipation pattern and consumer risk assessment
Food Addit Contam Part A Chem Anal Control Expo Risk Assess 2020 Jun;37(6):973-982.PMID:32186993DOI:10.1080/19440049.2020.1736342.
Picoxystrobin is a synthetic strobilurin fungicide widely used in Egypt to control downy and powdery mildews, a risk that is significant also in cultivating strawberries. In the ccurrent work, the safety to consumers from the use of Picoxystrobin in strawberries along with its residue behaviour was studied. Supervised field trials were conducted to investigate the residue dynamics and terminal residues of Picoxystrobin in strawberries under Egyptian conditions for several agricultural practices including worst-case scenarios. For the measurement of residues in fruit, a QuEChERS-based protocol coupled with LC-MS/MS was employed and successfully validated at 0.001 mg kg-1. A decline of Picoxystrobin residues in fruit fitted a first-order decay process with a calculated t1/2 of 5.4 days with a significant degradation (79%) after 14 days. A consumer risk assessment was performed employing both FAO/WHO and EFSA approaches, in which no significant health risks after consumption of strawberries were identified.
Residue determination of pyraclostrobin, Picoxystrobin and its metabolite in pepper fruit via UPLC-MS/MS under open field conditions
Ecotoxicol Environ Saf 2019 Oct 30;182:109445.PMID:31330408DOI:10.1016/j.ecoenv.2019.109445.
In this study, a new, high-efficiency and sensitive method was determined to simultaneous analyze the residue of pyraclostrobin, Picoxystrobin and its metabolite BF-500-3 in pepper fruit using modified QuEChERS pretreatment combined with ultra performance liquid chromatography-tandem mass spectrometry. The clean-up steps of QuEChERS procedure were optimized using the chemometric tools. Models of stepwise regression and surface response demonstrated that the optimal sorbent mixtures were 40 mg nano-zirconia + 10 mg C18 for pyraclostrobin and Picoxystrobin and 30 mg nano-zirconia + 20 mg C18 for BF-500-3. The optimized purification procedures provided satisfactory recoveries for all tested fungicides with rates between 91% and 107% and relative standard deviations between 3.7% and 9.6%. The limits of detection and quantification were in the range of 0.0360-0.272 μg/kg and 0.120-0.910 μg/kg. Based on this method, the dissipation of pyraclostrobin, Picoxystrobin and its metabolite in pepper fruit were determined under field conditions. Pyraclostrobin and Picoxystrobin degraded rapidly with half-lives of 5.53-7.02 and 5.97-7.82 days and 5.09 and 5.68 days in 2016 and 2017, respectively. The residue levels of BF-500-3 increased first and then decreased. The terminal residues of all fungicides were below the maximum residue limits (MRLs). This research can not only provide guidance for the reasonable usage of pyraclostrobin and Picoxystrobin in agriculture but also give a reference for the Chinese government to establish the MRL for pyraclostrobin in pepper.
Dissipation and residues of Picoxystrobin in peanut and field soil by QuEChERS and HPLC-MS/MS
Environ Monit Assess 2015 Aug;187(8):539.PMID:26223220DOI:10.1007/s10661-015-4773-2.
The dissipation and final residues of Picoxystrobin in peanut and soil were determined by a modified quick, easy, cheap, effective, rugged, and safe (QuEChERS) method and high-performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS). The dissipation and final residue of Picoxystrobin at three different provinces (Hebei, Hubei, and Shandong) in China were studied. The fortification experiments at three different spiking levels of 0.01, 0.05, and 0.5 mg kg(-1) in all matrices (soil, peanut seedling, shell, stalk, and kernels) were conducted, and the recoveries were 79-114% with relative standard deviations of 3-12 (n = 5). The dissipation half-lives of Picoxystrobin were 1.5-8.6 days in soil, and 2.1-2.8 days in seedlings. The final residues of Picoxystrobin in supervised field trials were 0.05-6.82 mg kg(-1) in stalk, ≤0.381 mg kg(-1) in soil, ≤0.069 mg kg(-1) in shells, and ≤0.005 mg kg(-1) in peanut kernels. Considering the final residue levels and the maximum residue limits (MRLs), the pre-harvest interval of 14 days was recommended for the safe use of Picoxystrobin in peanut crop.
Dissipation, residues and risk assessment of pyraclostrobin and Picoxystrobin in cucumber under field conditions
J Sci Food Agric 2020 Nov;100(14):5145-5151.PMID:32519755DOI:10.1002/jsfa.10563.
Background: Pyraclostrobin and Picoxystrobin are two representative pesticides of strobilurins used to treat cucumber downy mildew, which have raised issues of food safety and human health. A new formulation containing these two compounds is being prepared for marketing in China. Results: The dissipation and residual levels of pyraclostrobin and Picoxystrobin in cucumbers under field conditions were determined simultaneously by a validated method via liquid chromatography-tandem mass spectrometry (LC-MS/MS). The dissipation rules were described by first-order kinetics and the half-lives of pyraclostrobin and Picoxystrobin were less than 8.2 days and 3.4 days. The highest terminal residue of pyraclostrobin was 0.014 mg kg-1 which was lower than maximum residue limit (MRL) in China (0.5 mg kg-1 ) and of Picoxystrobin was 0.029 mg kg-1 , respectively. In the long-term intake risk assessment of pyraclostrobin and Picoxystrobin for general population (18-79 years), the chronic risk quotient (RQc ) varied from 5.64% to 21.97%. The assessment of short-term risks included children (1-6 years) and adults (18-79 years) and in which the RQa values were 0.38% and 2.85%. Both results showed the intake risks of cucumber were acceptable. Conclusion: Pyraclostrobin and Picoxystrobin degraded easily in cucumbers under open field conditions. The long-term and short-term risks caused by final residues of pyraclostrobin and Picoxystrobin were insignificant. The recommended pre-harvest interval of 3 days was safe. The article will be helpful in rational use of these pesticides and MRL formulation of Picoxystrobin on cucumber. © 2020 Society of Chemical Industry.