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Home >> Peptides

Peptides(肽)

  1. Cat.No. 产品名称 Information
  2. GA20725 Amyloid β-Protein (1-37) 淀粉样蛋白 β-蛋白质 (1-37) 与阿尔茨海默病的简易精神状态检查 (MMSE) 评分中度相关。
  3. GA20724 Amyloid β-Protein (1-24)
  4. GA20723 Amyloid β-Protein (11-42)
  5. GA20722 Amyloid β-Protein (1-14) The N-terminal Aβ fragments Aβ1-14, Aβ1-15 (H-6368), and Aβ1-16 (H-2958) are elevated in cell media and in CSF in response to γ-secretase inhibitor treatment. The presence of these small peptides is consistent with a catabolic amyloid precursor protein cleavage pathway by β- followed by α-secretase. It has been shown that Aβ1-14, Aβ1-15, and Aβ1-16 increase dose-dependently in response to γ-secretase inhibitor treatment while Aβ1-42 levels are unchanged.
  6. GA20721 Amyloid β-Protein (1-12)
  7. GA20720 Amyloid β-Protein (10-35) Amyloid β-protein (10-35), YEVHHQKLVFFAEDVGSNKGAIIGLM, was used as a truncated peptide model for the full-length amyloid β-proteins (1-40) and (1-42) in high-resolution structural studies. In contrast to the full-length amyloid β-proteins, amyloid β-protein (10-35) allowed the controlled and reproducible formation of homogeneous fibrils from aqueous solutions of defined pH, ionic strength and soluble peptide concentration necessary for high-resolution structural studies.
  8. GA20719 Amyloid β/A4 Protein Precursor₇₇₀ (740-770)

    淀粉样蛋白AMYLOIDΒ/A4PROTEINPRECURSOR???(740-770)

     Amyloid β/A4 Protein Precursor??? (740-770) corresponds to a C-terminal amyloid precursor protein (APP) fragment known as C31. This fragment is intracellularly generated by proteolytic cleavage of APP by caspases-8 and -9. C31 had a proapoptotic and a cytotoxic effect on neuronal cells and was shown to be present in brains of Alzheimer's disease (AD) patients. In cultured cells caspase cleavage of APP was induced by amyloid β-protein and the subsequent generation of C31 contributed to the apoptotic cell death associated with amyloid β-protein. Amyloid precursor binding protein BP1 (APP-BP1) a cell cycle protein which is increased in AD brain was demonstrated to bind to the C31 region of APP and to mediate APP-induced apoptosis.
  9. GA20718 Amyloid β/A4 Protein Precursor₇₇₀ (667-676)

    Β-基质分泌酶Ⅲ

     The peptide substrate APP (667-676), SEVKMDAEFR, corresponds to the wild-type amyloid precursor protein (APP) β-secretase cleavage site. SEVKMDAEFR has been used for assaying β-secretase activity.
  10. GA20710 Amylin (8-37) (human)

    糊精(8-370)(人)

     A peptide fragment of amylin
  11. GA20572 Ac-Gly-Lys-OMe

    α-N-Acetylglycyl-L-Lysine

     A peptide urokinase substrate
  12. GA20545 Acetyl-Pepstatin

    醋酸胃酶抑素,Pepstatin A acetate

     Acetyl-pepstatin 是一种有效的经典天冬氨酸蛋白酶 (PRs) 抑制剂，XMRV PR 和 HIV-1 PR Ki 值分别为 712 nM 和 13 nM。
  13. GA20540 Acetyl-Hirudin (54-65) (sulfated) 乙酰水蛭素 (54-65)（硫酸化）直接与凝血酶-rHCII(L444R) 结合并破坏 rHCII 的 N 端酸性结构域与用于稳定复合物的凝血酶的阴离子结合外部位点 I 之间的相互作用 。
  14. GA20535 Acetyl-Amyloid β-Protein (1-6) amide Experiments using sub-peptides of Aβ42 revealed that the epitope identified by the antibody A8, as described by Ying and coworkers, lies within the 1-6 region of Aβ. The antibody displays high affinity for soluble Aβ42 oligomers in the molecular weight range of 16.5-25 kDa, and detected target antigen in brain sections from senescence-accelerated SAMP 8 mice. Amidated or acetylated and amidated forms of the sequence were used for example for quantitative structure retention relationships (QSRR) experiments. The latter could allow prediction of reversed-phase high-performance liquid chromatography (HPLC) retention of peptides, as reported by Kaliszan and coworkers.
  15. GA20534 Acetyl-Amyloid β-Protein (15-20) amide Incubation of Ac-QKLVFF-NH? with the amyloid β-protein (1-40) inhibited polymerization of the amyloid β-protein (1-40) into amyloid fibrils. The peptide is thought to block the polymerization sites.
  16. GA20533 Acetyl-Amyloid β/A4 Protein Precursor₇₇₀ (96-110) (cyclized)

    乙酰基-淀粉样肽Β/A4蛋白质前体770(APP)(96-110)(环化)

     This cyclized peptide which is homologous to the heparin-binding domain of APP, binds strongly to heparin and inhibits binding of ¹²?I-labeled APP to heparin (IC??= 10??M). The peptide blocks the heparan sulfate proteoglycan-dependent stimulatory effect of APP on neurite outgrowth.
  17. GA20526 Acetyl-(Pro¹⁸,Asp²¹)-Amyloid β-Protein (17-21) amide 五肽 Ac-LPFFD-NH? (iAβ5p) 是产品 H-4876 的类似物，具有少量化学修饰，可增强其抗蛋白水解降解的稳定性。 iAβ5p 充当 77777#946;-片断肽并以比已知被大脑选择性吸收的大多数蛋白质和肽更高的速率穿过血脑屏障，因此假设该肽被特异性运输到大脑。 iAβ5p 还报道了两种不同的转基因阿尔茨海默病 (AD) 模型中与淀粉样斑块减少相关的神经元存活显着增加和脑部炎症减少。
  18. GA20525 Acetyl-(N-Me-Leu¹⁷,N-Me-Phe¹⁹)-Amyloid β-Protein (16-20) amide Membrane-permeable inhibitor of Aβ (1-40) fibrillogenesis.
  19. GA20481 Ac-Arg-Gly-Lys(Ac)-AMC

    Ac-Arg-Gly-Lys(Ac)-AMC 是 HDAC 的底物。
  20. GA20453 Abz-Amyloid β/A4 Protein Precursor₇₇₀ (708-715)-Lys(Dnp)-D-Arg-D-Arg-D-Arg amide A sensitive fluorogenic (FRET) substrate developed for the analysis of γ-secretase from post mortem non-Alzheimer's and Alzheimer's disease human brain isolates.
  21. GA20452 Abz-Amyloid β/A4 Protein Precursor₇₇₀ (669-674)-EDDnp Intramolecularly quenched fluorescent substrate containing the ortho-aminobenzoyl (Abz) / N-(2,4-dinitrophenyl)ethylenediamine (EDDnp) groups as the donor / acceptor pair. It mimicks the wild-type (JMV2235) β-amyloid precursor protein (βAPP) sequence targeted by β-secretase BACE (β-site APP-cleaving activity). This FRET substrate is cleaved by BACE1, BACE2, and cathepsin D.
  22. GA20448 Abz-(Asn⁶⁷⁰,Leu⁶⁷¹)-Amyloid β/A4 Protein Precursor₇₇₀ (669-674)-EDDnp Intramolecularly quenched fluorescent substrate containing the ortho-aminobenzoyl (Abz) / N-(2,4-dinitrophenyl)ethylenediamine (EDDnp) groups as the donor / acceptor pair. It corresponds to the Swedish-mutated (JMV2236) β-amyloid precursor protein (βAPP) sequence targeted by β-secretase BACE (β-site APP-cleaving activity). This FRET substrate is more selectively cleaved by BACE1 and BACE2 than by cathepsin D, a disintegrin and metalloprotease 10 (ADAM10), tumor necrosis α-converting enzyme (TACE), presenilin-1 (PS1), or presenilin-2 (PS2).
  23. GA20441 5-TAMRA-Amyloid β-Protein (1-42)
  24. GA20440 5-TAMRA-Amyloid β-Protein (1-40) Anderson and Webb could verify using transmission electron microscopy that N-terminal labeling of Aβ40 with TAMRA and other fluorescent dyes does not prevent the formation of protofibrils and amyloid fibrils of various widths.
  25. GA20435 5-FAM-Amyloid β-Protein (1-42)
  26. GA20434 5-FAM-Amyloid β-Protein (1-42) (scrambled) Fluorescent dye-labeled inactive control for H-1368, H-6466, H-8146.
  27. GA20433 5-FAM-Amyloid β-Protein (1-40)

    荧光标记淀粉样蛋白肽(1-40)

     5-FAM-Amyloid β；-Protein (1-40) 是 FAM 荧光标记的 β；-Amyloid (1-40) 肽（&Lambda；ex=492nm 和 &Lambda；em=518nm）。
  28. GA20341 (Val³⁴)-Amyloid β-Protein (1-40) Cerebral amyloid angiopathy (CAA) is a common finding in Alzheimer's disease in which amyloid-Aβ vascular deposits are featured in >80% of the cases. Mutations in the positions 21-23 (e.g. Dutch mutation E22Q) are primarily associated with CAA, although they manifest with strikingly different clinical phenotypes: cerebral hemorrhage or dementia. The Piedmont L34V Aβ mutant, located outside this hot spot, shows a similar hemorrhagic phenotype, albeit less aggressive than the widely studied Dutch variant.
  29. GA20340 (Val²)-Amyloid β-Protein (1-6)
  30. GA20339 (Val²)-Amyloid β-Protein (1-42) A mutation very close to the β-secretase cleavage site of APP (A673V). Contrary to the protective Icelandic mutation A2T, the recessive A2V mutation may increase the risk of Alzheimer's disease. Cantu et al. observed that APP A673V is associated with the early onset of AD-type dementia in homozygous individuals, whereas it has a protective effect in the heterozygous state.
  31. GA20328 (Tyr¹¹)-Somatostatin-14 (Tyr¹¹)-Somatostatin-14 是一种用于蛋白质组学研究的神经活性肽。
  32. GA20326 (Tyr¹)-Somatostatin-14 (Tyr¹)-Somatostatin-14 可以与 SSTR2 结合。
  33. GA20309 (Thr²)-Amyloid β-Protein (1-42) A mutation very close to the β-secretase cleavage site of APP. The Icelandic mutation A2T of Aβ42 turned out to be less pathogenic than the native sequence. The precursor APP A673T was the first APP variant discovered in humans reducing the risk of Alzheimer's disease. A2T as well affects γ-secretase cleavage, the mutant was an inefficient substrate in a cell-based assay of the enzyme.
  34. GA20291 (Sar¹)-Angiotensin II (Sar¹)-血管紧张素 II 是血管紧张素 II 的类似物，是血管紧张素 AT1 受体的特异性激动剂。
  35. GA20284 (Pyr³)-Amyloid β-Protein (3-42)

    (PYR3)-淀粉Β-蛋白

     (Pyr³)-Amyloid β-Protein (3-42) was found to be the predominant amyloid β-peptide structure deposited in human brain of Alzheimer's disease and Down's syndrome patients. Therefore, (Pyr³)-Aβ (3-42) is suggested to accumulate in the brain and to trigger the formation of insoluble amyloid β-peptide deposits. Nussbaum et al. studies the Prion-like behaviour and tau-dependent cytotoxicity of the truncated Aβ sequence.
  36. GA20283 (Pyr³)-Amyloid β-Protein (3-40) The pyroglutamate-modified amyloid-β peptides derived from Aβ40 (H-7422) and Aβ42 (H-4796) have gained considerable attention as potential key participants in the pathology of Alzheimer's disease (AD) due to their abundance in AD brain, high aggregation propensity, stability, and cellular toxicity. Aβ40 and 42 can be N-terminally truncated by action of cathepsin B. The cyclization of Glu³ is catalyzed by glutaminyl cyclase. Hence, inhibition of these enzymes could be a therapeutic approach to AD.
  37. GA20282 (Pyr¹¹)-Amyloid β-Protein (11-40) pEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV, the N-terminally truncated isoform of the amyloid β-protein (Aβ) beginning with a pyroglutamate (Pyr) residue at position 11 was used in experiments studying the generality of fibrillogenesis-related helix formation. Comparing the fibrillogenesis kinetics of many of the most important clinically relevant amyloid β-protein alloforms it could be observed that among these peptides (Pyr¹¹)-amyloid β-protein (11-40) exhibited the greatest retardation of fibrillization rate.
  38. GA20260 (Nle³⁵)-Amyloid β-Protein (1-42) The thioether of Met³? plays a critical role in the oxidative stress induced by Aβ 1-42 and its neurotoxicity. The norleucine analog Aβ 1-42 M35Nle forms fibrils morphologically indistinguishable from the ones of the native sequence though lacking their neurotoxicity.
  39. GA20259 (Nle³⁵)-Amyloid β-Protein (1-40) The reactive thioether of Met³? is crucial for the activity of Aβ 1-40 and Aβ 1-42. Due to the replacement of Met by inert Nle, M35Nle Aβ 1-40 was no longer toxic to cultured hippocampal neurons and had little effect on the level of protein carbonyl residues. The Nle peptide showed the same propensity to aggregate, whereas sulfoxide formation hindered the required conformational transition from random coil to β-sheet.
  40. GA20254 (Met(O₂)³⁵)-Amyloid β-Protein (1-42) Maiti et al. could show that, in contrast to the sulfoxide of Aβ (1-42), the sulfone was as toxic and aggregated as fast as wild-type Aβ (1-42).
  41. GA20253 (Met(O)³⁵)-Amyloid β-Protein (25-35) Sulfoxide of Aβ 25-35.
  42. GA20252 (Met(O)³⁵)-Amyloid β-Protein (1-42) (Met(O)³?)-Amyloid β-protein (1-42) (H-5888), in contrast to Aβ 1-42 (H-1368), has been shown to be non-toxic to 9-11 day-old rat embryonic hippocampal neuronal cultures and not to produce any protein oxidation. It has also been demonstrated that fibril formation is not affected by Met(O)³?. For the Nle analog see H-7308.
  43. GA20251 (Met(O)³⁵)-Amyloid β-Protein (1-40) Oxidation of Met35 attenuates the formation of Aβ40 oligomers.
  44. GA20245 (Lys²²)-Amyloid β-Protein (1-42) The Italian mutation (E22K) aggregates more rapidly than the wild-type sequence.
  45. GA20244 (Lys²²)-Amyloid β-Protein (1-40) The Italian mutation of β-amyloid 1-40 (E22K) aggregates more rapidly than the wild-type sequence 1-40. It showed increased neurotoxicity, which (according to a solid-phase NMR-study of Masuda et al.) may be due to the salt bridge formed between Lys²² and Asp²³ in the minor conformer. As the Arctic, Flemish, and Dutch mutants, the Italian mutant is degraded considerably more slowly than wild-type Aβ by neprilysin.
  46. GA20242 (Lys¹⁵)-Amyloid β-Protein (15-21)

    Β淀粉样肽改造多肽-[LYS15]-AMYLOIDΒ-PROTEIN(15-21)

     KKLVFFA contains the KLVFF sequence, which is the minimum sequence binding the full-length amyloid β-protein. It showed improved water solubility compared with KLVFF (H-3682). It can be used as a labeled probe for screening defined sequences in the full-length amyloid β-protein.
  47. GA20229 (Leu³¹,Pro³⁴)-Neuropeptide Y (human, rat) (Leu³¹,Pro³⁴)-Neuropeptide Y (human, rat) 是一种特异性的神经肽 Y Y1 受体激动剂。
  48. GA20221 (Hyp³)-Bradykinin

    [Hyp3]-缓激肽

     (Hyp³)-缓激肽，天然存在的肽激素，是一种缓激肽受体激动剂。
  49. GA20205 (H-Cys-Gly-OH)₂

    (Cys-Gly)2, (H-Cys-Gly-OH)2, NSC 333711

     NSC333711. Besides its reduced form, this product of glutathione metabolism is found in plasma.
  50. GA20201 (Gly²⁸,Cys³⁰)-Amyloid β-Protein (1-30) amide
  51. GA20200 (Gly²²)-Amyloid β-Protein (1-42) The arctic mutant of amyloid β peptide 1-42, in which Glu²² is substituted by Gly, is distinctly more amyloidogenic than the wild-type Aβ 1-42.

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