Penicillin V Potassium (Phenoxymethylpenicillin potassium salt)
(Synonyms: 青霉素 V 钾; Phenoxymethylpenicillin potassium salt) 目录号 : GC32246
A β-lactam antibiotic
Cas No.:132-98-9
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Penicillin V is a β-lactam antibiotic that inhibits the growth of bacteria.1,2,3 In vitro, penicillin V inhibits the growth of clinical isolates of Streptococci (MICs = 0.004-0.008 mg/l) and C. difficile (MICs = 1 to >256 mg/l).1,2 Penicillin V also inhibits growth of S. aureus in vitro (MIC = 0.016 mg/l) and in vivo in a thigh model of infection in mice.3 It inhibits the growth of S. pyogenes in mice following one or two dose therapy with curative dose (CD50) values of 0.207 and 0.031 mg, respectively.4 Penicillin V (100 mg/kg per day, p.o.) prevents experimental acute otitis media in rats when administered prior to infection by pneumococci.5 Formulations containing penicillin V have been used to treat bacterial infections of the skin, throat, ear, mouth, and respiratory tract.
1.Kamme, C., and Petersson, A.C.In vitro effect on group A streptococci of loracarbef versus cefadroxil, cefaclor and penicillin VScand. J. Infect. Dis.25(1)37-42(1993) 2.Norén, T., Alriksson, I., Akerlund, T., et al.In vitro susceptibility to 17 antimicrobials of clinical Clostridium difficile isolates collected in 1993-2007 in SwedenClin. Microbiol. Infect.16(8)1104-1110(2010) 3.Overbosch, D., Mattie, H., and Van Furth, R.Comparative pharmacodynamics and clinical pharmacokinetics of phenoxymethylpenicillin and pheneticillinBr. J. Clin. Pharmacol.19(5)657-668(1985) 4.Powell, H.M., and Culbertson, C.G.Effectiveness of phenoxymethyl penicillin V, and sodium penicillin G against hemolytic Streptococcus infection in white miceProc. Soc. Exp. Biol. Med.90(1)186-187(1955) 5.Hermansson, A., Prellner, K., and Hellstr?m, S.Prevention of experimental acute otitis media with penicillin VActa Otolaryngol.109(1-2)119-123(1990)
| Cas No. | 132-98-9 | SDF | |
| 别名 | 青霉素 V 钾; Phenoxymethylpenicillin potassium salt | ||
| Canonical SMILES | [O-]C([C@@H](C(C)(C)S[C@]1([H])[C@@H]2NC(COC3=CC=CC=C3)=O)N1C2=O)=O.[K+] | ||
| 分子式 | C16H17KN2O5S | 分子量 | 388.48 |
| 溶解度 | DMSO : 12 mg/mL (30.89 mM);Water : 6 mg/mL (15.44 mM) | 储存条件 | Store at 2-8°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
||
| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 2.5741 mL | 12.8707 mL | 25.7414 mL |
| 5 mM | 0.5148 mL | 2.5741 mL | 5.1483 mL |
| 10 mM | 0.2574 mL | 1.2871 mL | 2.5741 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Isolation, Screening, and Characterization of Antibiotic-Degrading Bacteria for Penicillin V Potassium (PVK) from Soil on a Pig Farm
Int J Environ Res Public Health 2019 Jun 19;16(12):2166.PMID:31248086DOI:10.3390/ijerph16122166.
(1) Background: Antibiotics are frequently used on farm animals, making animal husbandry a relatively large source of antibiotic pollution of the environment. The present study aims to isolate and acclimatize antibiotic-degrading bacterial strains for Penicillin V Potassium (PVK) from the contaminated soil of a pig farm. (2) Methods: Bacterial strains were isolated and acclimatized by continuous enrichment of cultures with PVK as the sole carbon source. The antibiotic susceptibility test, thiol mercury salt ultraviolet spectrophotometry (TMSUS), morphological observations, and 16S rDNA sequence analysis were used to identify and characterize the isolated strains. (3) Results: Four bacterial isolates (denoted as LM-1, LM-2, LM-3, LM-4) were obtained, and two of them (LM-1, LM-2) with the highest degradation rates were identified to belong to the same genera as Bacillus. These two isolates were found to be resistant to PVK antibiotic in an antibiotic sensitivity test. The TMSUS indicated that the strains LM-1 and LM-2 had good performance in PVK degradation (68% for LM-1, 66% for LM-2 in 48 h) when the initial PVK concentration was about 100 μg/mL. (4) Conclusions: Two bacterial strains isolated from the soil on a pig farm are effective in degrading PVK and can be potentially used for bioremediation of PVK antibiotic-contaminated soils.
Clinical management of the avulsed tooth
Dent Clin North Am 1995 Jan;39(1):93-112.PMID:7890110doi
Treatment outside the dental office: Replant immediately after gentle washing if practical. If replantation is not practical, store the tooth in the best medium available. Storage media in order of preference are Hank's Balanced Salt Solution (HBSS), milk, saline, and saliva (buccal vestibule). Water is the least desirable storage medium. Treatment in the office: Emergency visit; Place tooth in HBSS while exam is conducted and history is taken. Prepare socket for gentle repositioning of the tooth. Prepare the root. Extraoral dry time < 20 minutes: Closed apex--replant immediately after gentle washing. Open apex--soak in 1 mg doxycycline in 20 mg saline for 5 minutes. Extraoral dry time 20 to 60 minutes: Soak in HBSS for 30 minutes and replant. Extraoral dry time > 60 minutes: soak in citric acid, 2% stannous fluoride, and doxycycline and replant. Endodontics can be done extraorally. Semirigid splint for 7 to 10 days. (If alveolar fracture is present, rigid splint for 4 to 8 weeks). Suture soft-tissue lacerations, particularly in the cervical area. Administer systemic antibiotics (Penicillin V Potassium if possible) Chlorhexidine rinses and stringent oral hygiene while the splint is in place (7 to 10 days). Analgesics as required. Second visit after 7 to 10 days: Endodontic treatment: Tooth with open apex and extraoral dry time of < 60 minutes: No endodontic treatment initially. Recall every 3 to 4 weeks to examine for evidence of pathosis. If pathosis is noted, disinfect the pulp space and start apexification procedure. Tooth with open apex and extraoral dry time > 60 minutes: If endodontics was not completed in the emergency visit, start endodontics and follow apexification procedure. Tooth with closed apex: Endodontics should be initiated after 7 to 10 days. Careful chemomechanical instrumentation under strict asepsis. Splint removed at end of visit. Obturation visit: If endodontics was initiated 7 to 10 days after the avulsion, obturation can take place after short-term calcium hydroxide treatment. If endodontics was initiated more than 14 days after the avulsion or inflammatory resorption, long-term calcium hydroxide for 6 to 24 months, obturated when an intact lamina dura is traced. Restorations: Temporary restorations: Should be 4 mm deep. Reinforced zinc-oxide-eugenol, acid-etch composite resin, glass-ionomer cement. Permanent restoration: Placed immediately after obturation. Acid-etch resin and dentin bonding agents. Follow-up care: Twice per year for 3 years and yearly for as long as possible. Late complications are common.