Penicillin G potassium (Benzylpenicillin potassium)

Penicillin G

Hyperkalaemia. Benzylpenicillin potassium

Degradation of Penicillin G by heat activated persulfate in aqueous solution

We used Heat Activated of Persulfate (HAP) to decompose Penicillin G (PEN G) in aqueous solution. The effect of pH (3-11), temperature (313-353 K), and initial concentration of Sodium Persulfate (SPS) (0.05-0.5 mM) on the decomposition level of PEN G were investigated. The residue of PEN G was determined by spectrophotometry at the wavelength of 290 nm. Also, the Chemical Oxygen Demand (COD) was measured in each experiment. The Total Organic Carbon (TOC) analysis was utilized for surveying the mineralization of PEN G. In addition, based on Arrhenius equation, the activation energy of PEN G decomposition was calculated. The results indicated that the maximum PEN G removal rate was obtained at pH 5 and by increasing the doses of SPS from 0.05 to 0.5 mM, the PEN G decomposition was enhanced. It was found that an increase in temperature is accompanied by an increase in removal efficiency of PEN G. The activation energy of the studied process was determined to be 94.8 kJ mol^-1, suggesting that a moderate activation energy is required for PEN G decomposition. The TOC measurements indicate that the HAP can efficiently mineralize PEN G. Besides, the presence of the scavengers significantly suppressed the HAP process to remove the PEN G. Overall, the results of this study demonstrate that using HAP process can be a suitable method for decomposing of PEN G in aqueous solutions.

Identification of Penicillin G Metabolites under Various Environmental Conditions Using UHPLC-MS/MS

In this work, we investigate the stability of penicillin G in various conditions including acidic, alkaline, natural acidic matrices and after treatment of citrus trees that are infected with citrus greening disease. The identification, confirmation, and quantitation of penicillin G and its various metabolites were evaluated using two UHPLC-MS/MS systems with variable capabilities (i.e., Thermo Q Exactive Orbitrap and Sciex 6500 QTrap). Our data show that under acidic and alkaline conditions, penicillin G at 100 ng/mL degrades quickly, with a determined half-life time of approximately 2 h. Penillic acid, penicilloic acid, and penilloic acid are found to be the most abundant metabolites of penicillin G. These major metabolites, along with isopenillic acid, are found when penicillin G is used for treatment of citrus greening infected trees. The findings of this study will provide insight regarding penicillin G residues in agricultural and biological applications.

Treatment of pneumococcal pneumonia: the case for penicillin G

Although widely endorsed for specific treatment of pneumococcal pneumonia, penicillin G is seldom used for this purpose in clinical practice for at least three reasons: (1) concern about penicillin-resistant Streptococcus pneumoniae (PRSP) strains; (2) the difficulty of making an early etiologic diagnosis of pneumonia; and (3) lack of a clear consensus about the optimum dosage. Continuous infusion of 20-24 million units of penicillin per day provides serum levels of 16-20 microg/mL in persons with normal renal function. These levels easily exceed the minimum inhibitory concentrations (MICs) of penicillin G against most PRSP strains (4 microg/mL), which are actually strains with reduced susceptibility to penicillin. High-dose penicillin G therapy has not been shown to be therapeutically ineffective against pneumonia due to PRSP strains. However, the extent of penicillin resistance warrants continued monitoring, because strains exhibiting extremely high-level resistance (MIC > or = 8 microg/mL) would probably respond poorly if at all. Development and use of rapid, sensitive, specific ways to diagnose pneumococcal pneumonia could extend the usefulness of penicillin G, thus postponing the emergence of resistance to other antibiotics.