Paulownin
(Synonyms: 泡桐素,(+)-Paulownin) 目录号 : GC64886
Paulownin 是一种泡桐木的成分，是一种药用植物的成分。
Cas No.:13040-46-5
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Paulownin, a component of wood of Paulownia tomentosa Steud, is a constituent of medicinal plants[1].
[1]. TAKAHASHI K, et al. [STUDIES ON CONSTITUENTS OF MEDICAL PLANTS. IV. CHEMICAL STRUCTURE OF PAULOWNIN, A COMPONENT OF WOOD OF PAULOWNIA TOMENTOSA STEUD]. Yakugaku Zasshi. 1963 Dec;83:1101-5.
| Cas No. | 13040-46-5 | SDF | Download SDF |
| 别名 | 泡桐素,(+)-Paulownin | ||
| 分子式 | C20H18O7 | 分子量 | 370.35 |
| 溶解度 | DMSO : 100 mg/mL (270.01 mM; Need ultrasonic) | 储存条件 | 4°C, protect from light |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.7001 mL | 13.5007 mL | 27.0015 mL |
| 5 mM | 0.54 mL | 2.7001 mL | 5.4003 mL |
| 10 mM | 0.27 mL | 1.3501 mL | 2.7001 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Novel lignan-based compounds via click chemistry: Paulownin isolation, structural modifications and cytotoxic activity evaluations
Nat Prod Res 2021 Nov;35(21):3820-3823.PMID:32174174DOI:10.1080/14786419.2020.1739683.
Paulownin, a natural compound obtained from the tree Tecoma stans var. stans, was chemically modified by alkylation of its hydroxyl position. Thirteen novel lignans derivatives synthesized via a copper-catalyzed cycloaddition (CuAAC), known as click reaction, using different organic azides and lignan terminal alkyne. Characterization by mass spectrometry, NMR (1H and 13C) and infrared spectroscopy. These novel molecules were submitted to biological tests, using the MTT colorimetric technique aiming at the verification of their antitumor properties with six different cells lines. Biological evaluation was satisfactory and one of compounds showed selectivity index ten times higher than podophyllotoxin.
Abietane diterpenoids from Sideritis montana L. and their antiproliferative activity
Fitoterapia 2017 Oct;122:90-94.PMID:28864041DOI:10.1016/j.fitote.2017.08.016.
The present study aimed at the phytochemical and pharmacological investigation of Sideritis montana L. (Lamiaceae). Two new abietane diterpenes [sideritins A (1) and B (2)] were isolated from the methanol extract of the plant. Six known compounds [pomiferin E (3), 9α,13α-epi-dioxyabiet-8(14)-en-18-ol (4), Paulownin (5), 6-methoxysakuranetin (6), 3-oxo-α-ionol (7) and 4-allyl-2,6-dimethoxyphenol glucoside (8)] were also obtained from the plant. The structures were determined by means of HREIMS and NMR experiments. The antiproliferative effect of the isolated compounds was investigated on human cancer cell lines (HeLa, SiHa and C33A) at 10 and 30μM concentrations, using the MTT assay. The results demonstrated that pomiferin E (3) and 6-methoxysakuranetin (6) displayed considerable activity [inhibition (%)±SEM: 46.93±2.35 on HeLa (pomiferin E), and 51.52±2.45 on C33A (6-methoxysakuranetin)] at 30μM concentration.
Cathayanalactone G and other constituents from leaves and twigs of Callicarpa cathayana
Chin Herb Med 2022 Feb 26;14(2):332-336.PMID:36117667DOI:10.1016/j.chmed.2021.05.006.
Objective: To study the chemical constituents from the leaves and twigs of Callicarpa cathayana. Methods: The chemical constituents were isolated and purified by column chromatography on silica gel, MCI gel CHP 20P/P120, Sephadex LH-20, and HPLC. The structures of the compounds were determined by HR-ESI-MS, 1D and 2D NMR data. Results: A total of 24 compounds were isolated from the 85% methanol extract of leaves and twigs of C. cathayana. They were identified as cathayanalactone G (1), a new diterpene, and 23 known compounds as patagonic acid (2), (-)-16-hydroxycledroda-3,13-dien-16,15-olide-18-oic acid (3), 15-methoxypatagonic acid (4), oleanolic acid (5), ursolic acid (6), siaresinolic acid (7), pomolic acid (8), α-amyrin (9), tormentic acid (10), lupeol (11), 5,7-dihydroxy-3,4'-dimethoxyflavone (12), 5,4'-dihydroxy-3,7,3'-dimethoxyfla-vone (13), 5-hydroxy-3,6,7,4'- tetramethoxyflavone (14), salvigenin (15), kaemferol (16), astragalin (17), pinoresinol 4-O-β-D-glucopyranoside (18), Paulownin (19), β-sitosterol (20), β-sitosterol β-D-glucopyranoside (21), 5-hydroxy-coumarin (22), isocopoletin (23), and 4-hydroxycinnamic acid (24). Conclusion: Compound 1 is a new labdane diterpene. Compounds 10, 13, 16 and 17 are isolated from the genus Callicarpa for the first time. Compounds 7, 8, 9, 12, 14, 23 and 24 are reported from C. cathayana for the first time.
Lignans and other constituents from the roots of the Vietnamese medicinal plant Pseuderanthemum palatiferum
Planta Med 2011 Jun;77(9):951-4.PMID:21243588DOI:10.1055/s-0030-1250683.
Two new lignans, palatiferin A (1) and palatiferin B (2), were isolated from the roots of Pseuderanthemum palatiferum, together with five known triterpenes, epifriedelanol (3), lupeol (4), lupenone (5), betulin (6), pomolic acid (7), and a dipeptide asperglaucide (8). Their structures were established from 2D NMR and mass spectroscopy. The absolute configuration of 1 and 2 was proposed based on the comparison of their optical rotation activities with those of compounds with similar structures such as wodeshiol and Paulownin. The new lignans, palatiferin A (1) and palatiferin B (2) exhibited a moderate cytotoxicity against KB and HepG2 cell lines. However, betulin and lupeol, two abundant compounds from the roots of P. palatiferum, showed cytotoxic and antimicrobial activities.
Isolation and structure of cleistanthoside A
Planta Med 1983 Apr;47(4):227-9.PMID:17404921DOI:10.1055/s-2007-969993.
A new diphyllin diglycoside, named Cleistanthoside A has been isolated from the heartwood of Cleistanthus patulus Muell., A RG., and its structure elucidated as diphyllin-4-O-[beta- D-glucopyranosyl (1-->2)]-beta-3,4-di-O-methyl- D-xylopyranoside. Other lignans isolated were (+)-sesamin, taiwanin C, Paulownin, cleistanthin A and diphyllin, also beta-sitosterol.