Pasakbumin B
(Synonyms: 13ALPHA(21)-环氧宽缨酮,13α-(21)-Epoxyeurycomanone) 目录号 : GC38977Pasakbumin B 是一种来自 Eurycoma longifolia Jack 的生物活性化合物,显示出有效的抗溃疡活性。
Cas No.:138809-10-6
Sample solution is provided at 25 µL, 10mM.
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- Purity: >98.00%
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Pasakbumin B, a bioactive compound from Eurycoma longifolia Jack, exhibits potent antiulcer activity[1].
[1]. Bhat R, et al. Tongkat Ali (Eurycoma longifolia Jack): a review on its ethnobotany and pharmacological importance. Fitoterapia. 2010 Oct;81(7):669-79.
Cas No. | 138809-10-6 | SDF | |
别名 | 13ALPHA(21)-环氧宽缨酮,13α-(21)-Epoxyeurycomanone | ||
Canonical SMILES | O[C@@]1([C@H]2O)[C@@]34[C@@]([C@](OC4)(O)[C@H](O)[C@]15CO5)([H])[C@]([C@@](C(C)=CC6=O)([H])C[C@@]3([H])OC2=O)([C@@H]6O)C | ||
分子式 | C20H24O10 | 分子量 | 424.4 |
溶解度 | Soluble in DMSO | 储存条件 | 4°C, protect from light |
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1 mg | 5 mg | 10 mg | |
1 mM | 2.3563 mL | 11.7813 mL | 23.5627 mL |
5 mM | 0.4713 mL | 2.3563 mL | 4.7125 mL |
10 mM | 0.2356 mL | 1.1781 mL | 2.3563 mL |
第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量) | ||||||||||
给药剂量 | mg/kg | 动物平均体重 | g | 每只动物给药体积 | ul | 动物数量 | 只 | |||
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% DMSO % % Tween 80 % saline | ||||||||||
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工作液浓度: mg/ml;
DMSO母液配制方法: mg 药物溶于 μL DMSO溶液(母液浓度 mg/mL,
体内配方配制方法:取 μL DMSO母液,加入 μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入 μL saline,混匀澄清。
1. 首先保证母液是澄清的;
2.
一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。
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Tongkat Ali (Eurycoma longifolia Jack): a review on its ethnobotany and pharmacological importance
Fitoterapia 2010 Oct;81(7):669-79.PMID:20434529DOI:10.1016/j.fitote.2010.04.006.
Eurycoma longifolia Jack is an herbal medicinal plant of South-East Asian origin, popularly recognized as 'Tongkat Ali.' The plant parts have been traditionally used for its antimalarial, aphrodisiac, anti-diabetic, antimicrobial and anti-pyretic activities, which have also been proved scientifically. The plant parts are rich in various bioactive compounds (like eurycomaoside, eurycolactone, eurycomalactone, eurycomanone, and Pasakbumin-B) among which the alkaloids and quassinoids form a major portion. Even though toxicity and safety evaluation studies have been pursued, still a major gap exists in providing scientific base for commercial utilization and clearance of the Tongkat Ali products with regard to consumer's safety. The present review aims at reviewing the research works undertaken till date, on this plant in order to provide sufficient baseline information for future works and for commercial exploitation.