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Orexin B amide (human) (trifluoroacetate salt) Sale

(Synonyms: Hypocretin 2, OXB) 目录号 : GC49553

A hypothalamic neuropeptide

Orexin B amide (human) (trifluoroacetate salt) Chemical Structure

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500 µg
¥4,902.00
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产品描述

Orexin B amide is a hypothalamic neuropeptide that regulates feeding behavior, wakefulness, and behavior under situations of high motivational relevance.1 It is an agonist of orexin (OX) receptors with IC50 values of 420 and 36 nM for human recombinant OX1 and OX2 receptors, respectively, expressed in CHO cells.2 It induces transient increases in intracellular calcium in CHO cells stably expressing OX1 and OX2 (EC50s = 2,500 and 60 nM, respectively) and in primary rat ventral tegmental area (VTA) dopaminergic neurons.2,3 Orexin B amide stimulates arachidonic acid release from CHO cells expressing human recombinant OX1 (EC50 = 4.17 nM).4 It also stimulates food intake in freely feeding mice and goldfish when administered at intracerebroventricular doses of 30 nmol and 10 ng/g, respectively.2,5

1.Mahler, S.V., Moorman, D.E., Smith, R.J., et al.Motivational activation: A unifying hypothesis of orexin/hypocretin functionNat. Neurosci.17(10)1298-1303(2014) 2.Sakurai, T., Amemiya, A., Ishii, M., et al.Orexins and orexin receptors: A family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behaviorCell92(4)573-585(1998) 3.Nakamura, T., Uramura, K., Nambu, T., et al.Orexin-induced hyperlocomotion and stereotypy are mediated by the dopaminergic systemBrain Res.873(1)181-187(2000) 4.Turunen, P.M., Ekholm, M.E., Somerharju, P., et al.Arachidonic acid release mediated by OX1 orexin receptorsBr. J. Pharmacol.159(1)212-221(2010) 5.Volkoff, H., Bjorklund, J.M., and Peter, R.E.Stimulation of feeding behavior and food consumption in the goldfish, Carassius auratus, by orexin-A and orexin-BBrain Res.846(2)204-209(1999)

Chemical Properties

Cas No. N/A SDF Download SDF
别名 Hypocretin 2, OXB
Canonical SMILES NC([C@@H](NC([C@@]([C@@H](C)O)([H])NC([C@H](CC(C)C)NC([C@@]([C@H](CC)C)([H])NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC(N)=O)NC(CNC([C@H](CO)NC([C@@H](NC([C@H](CCC(N)=O)NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC([C@H](CCCNC(N)=N)NC([C@H](CCC(N)=O)NC([C@H](CC(C)C)NC([C@H](CCCNC(N)=N)NC(CNC([C@H](CCC(N)=O)NC([C@H](CC(C)C)NC(CNC([C@@H]1CCCN1C([C@@H]2CCCN2C(CNC([C@H](CO)NC([C@H](CCCNC(N)=N)N[H])=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C)=O)=O)=O)=O)CC3=CN=CN3)=O)C)=O)C)=O)=O)=O)=O)=O)CCSC)=O.FC(F)(C(O)=O)F
分子式 C123H212N44O35S • XCF3COOH 分子量 2899.3
溶解度 Water: 1 mg/ml 储存条件 -20°C
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1 mM 0.3449 mL 1.7246 mL 3.4491 mL
5 mM 0.069 mL 0.3449 mL 0.6898 mL
10 mM 0.0345 mL 0.1725 mL 0.3449 mL
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