Olivetolic Acid
(Synonyms: 2,4-二羟基-6-戊基苯甲酸,Olivetolate, Olivetolcarboxylic Acid) 目录号 : GC41526
Olivetolic acid是一种天然聚酮化合物，为大麻中所有大麻素类物质的生物合成前体，可用于研究植物次生代谢及大麻素合成途径。
Cas No.:491-72-5
Sample solution is provided at 25 µL, 10mM.
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Olivetolic acid is a natural polyketide compound that serves as the universal biosynthetic precursor of all cannabinoids in Cannabis sativa[1-2].
In a mouse model of Dravet syndrome Scn1a⁺/⁻, a single intraperitoneal injection of 10-100mg/kg of Olivetolic acid, Olivetolic acid (100mg/kg), significantly increased the temperature threshold of heat-induced tonic-clonic seizures by about 0.4°C, showing anticonvulsant effects[3].
References:
[1] Giangrossi M, Salamone S, Camola A, et al. Taglialatela-Scafati O, Chianese G, Gargiulo E, Nabissi M, Pollastro F. Biomimetic synthesis of rare cannabigerol-type cannabinoids and evaluation of their cytotoxic effect on human glioblastoma cell lines. Fitoterapia. 2025 Mar;181:106354.
[2] Ismed F, Farhan A, Bakhtiar A, et al. Crystal structure of olivetolic acid: a natural product from Cetrelia sanguinea (Schaer.). Acta Crystallogr E Crystallogr Commun. 2016 Oct 18;72(Pt 11):1587-1589.
[3] Anderson LL, Udoh M, Everett-Morgan D, et al. Olivetolic acid, a cannabinoid precursor in Cannabis sativa, but not CBGA methyl ester exhibits a modest anticonvulsant effect in a mouse model of Dravet syndrome. J Cannabis Res. 2022 Jan 4;4(1):2.
Olivetolic acid是一种天然聚酮化合物，为大麻中所有大麻素类物质的生物合成前体，可用于研究植物次生代谢及大麻素合成途径[1-2]。
在Dravet综合征Scn1a⁺/⁻小鼠模型中，单次腹腔注射10-100mg/kg的Olivetolic acid，Olivetolic acid（100mg/kg）可显著提高热诱导强直-阵挛发作的温度阈值约0.4°C，表现出抗惊厥效果[3]。
| Animal experiment [1]: | |
Animal models | Scn1a+/- mice |
Preparation Method | Mice were acclimated to a rectal temperature probe for 5min, then received a single intraperitoneal injection of vehicle or Olivetolic acid (10–100mg/kg). Immediately afterward, core body temperature was elevated 0.5°C every 2min until the first generalized tonic-clonic seizure (GTCS) with loss of posture or until 42.5°C was reached. |
Dosage form | 10–100mg/kg; i.p. |
Applications | Olivetolic acid modestly but significantly increased the hyperthermia-induced seizure threshold in Scn1a+/- mice, indicating anticonvulsant activity comparable to cannabidiol at the same dose. |
References: | |
| Cas No. | 491-72-5 | SDF | |
| 别名 | 2,4-二羟基-6-戊基苯甲酸,Olivetolate, Olivetolcarboxylic Acid | ||
| 化学名 | 2,4-dihydroxy-6-pentyl-benzoic acid | ||
| Canonical SMILES | OC1=CC(O)=C(C(O)=O)C(CCCCC)=C1 | ||
| 分子式 | C12H16O4 | 分子量 | 224.3 |
| 溶解度 | 50mg/mL in DMSO, 50mg/mL in DMF, 50mg/mL in Ethanol | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 4.4583 mL | 22.2916 mL | 44.5831 mL |
| 5 mM | 0.8917 mL | 4.4583 mL | 8.9166 mL |
| 10 mM | 0.4458 mL | 2.2292 mL | 4.4583 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet