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Nosantine racemate (NPT-15392 racemate) Sale

(Synonyms: 诺次黄嘌呤外消旋体; NPT 15392 racemate) 目录号 : GC33873

Nosantine 外消旋体 (NPT-15392 racemate) 是 Nosantine 的外消旋体。

Nosantine racemate (NPT-15392 racemate) Chemical Structure

Cas No.:75166-67-5

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1mg
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Sample solution is provided at 25 µL, 10mM.

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实验参考方法

Animal experiment:

Rats[2] Animals in seven of the groups are also injected subcutaneously with various dosage regimens of the immunomodulating drugs, isoprinosine (ISO), Nosantine (NPT 15392), avridine (AVD) and cyclophosphamide (CY). Individual rats in each group receive drug treatments consisting of 5 or 50 mg/kg ISO, 0.1 or 1.0 mg/kg Nosantine, 1 or 25 mg/kg AVD, or 75 mg/kg CY. Injections of ISO, Nosantine and AVD are given at three separate time intervals in relation to injection with bovine serum albumin (BSA). Isoprinosine and Nosantine are given twice at the same time as each BSA injection and a third time 3 days before termination. All rats are sacrificed by asphyxiation with CO2 and assayed for immunocompetence 14 days after the initial BSA and KLH injections. Six separate immunoassays are performed to assess different immune responses in the same animal.

References:

[1]. Wiranowska-Stewart M, et al. Effects of isoprinosine and NPT 15392 on interleukin-2 (IL-2) production. Int J Immunopharmacol. 1986;8(1):63-9.
[2]. Exon JH, et al. The selectivity of isoprinosine, NPT 15392, avridine and cyclophosphamide on multiple immuneresponses in rats. Int J Immunopharmacol. 1986;8(1):53-62.

产品描述

Nosantine racemate is the racemate of Nosantine. Nosantine is an inducer of IL-2 or enhancer of IL-2 induction by phytohemagglutinin (PHA).

The purine immunoenhancing drug Nosantine (NPT 15392) is evaluated as an inducer of IL-2 or enhancer of IL-2 induction by phytohemagglutinin (PHA). Nosantine is found to has significant enhancing activity on PHA induction of IL-2 by human lymphocytes over a wide range of concentrations[1].

Multiple concomitant immune responses are assessed in individual rats following treatment with the immunoenhancing drugs, Isoprinosine (5 or 50 mg/kg), Nosantine (0.1 or 1.0 mg/kg) and Avridine (1 or 25 mg/kg), or the immunosuppressant, Cyclophosphamide (75 mg/kg). Rats treated with Nosantine (NPT 15392) have significantly enhanced DTH reactions at the 0.1 mg/kg dose. It can be concluded that NPT 15392 act as general immunostimulants in the rat, with avridine having the greatest effect under these experimental conditions[2].

[1]. Wiranowska-Stewart M, et al. Effects of isoprinosine and NPT 15392 on interleukin-2 (IL-2) production. Int J Immunopharmacol. 1986;8(1):63-9. [2]. Exon JH, et al. The selectivity of isoprinosine, NPT 15392, avridine and cyclophosphamide on multiple immuneresponses in rats. Int J Immunopharmacol. 1986;8(1):53-62.

Chemical Properties

Cas No. 75166-67-5 SDF
别名 诺次黄嘌呤外消旋体; NPT 15392 racemate
Canonical SMILES O=C1N=CNC2=C1N=CN2C(C(O)C)CCCCCC
分子式 C14H22N4O2 分子量 278.35
溶解度 Soluble in DMSO 储存条件 Store at -20°C
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 3.5926 mL 17.963 mL 35.926 mL
5 mM 0.7185 mL 3.5926 mL 7.1852 mL
10 mM 0.3593 mL 1.7963 mL 3.5926 mL
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