NH2-UAMC1110 TFA

NH2-UAMC1110 TFA is a UAMC1110 derivative that can be used to synthesize FAPI-QS. UAMC1110 is an inhibitor of fibroblast activation protein (FAP), a proline-selective serine protease that is overexpressed in tumor stroma and in many other diseases characterized by tissue remodeling^{[1, 2]}. FAPI-QS is a chelating agent that can be used to synthesize highly tumor-selective and high-dose radiotracers for tumor diagnosis and treatment^[3].

References:
[1] Moon E S, Elvas F, Vliegen G, et al. Targeting fibroblast activation protein (FAP): next generation PET radiotracers using squaramide coupled bifunctional DOTA and DATA 5m chelators[J]. EJNMMI radiopharmacy and chemistry, 2020, 5: 1-20.
[2] Young K H, McCarty K, Friedman D, et al. Preclinical combination of radiation and fibroblast activation protein inhibition in pancreatic cancer[J]. 2016.
[3] Mortensen J K, Mattiussi S, Hvass L, et al. [68Ga] Ga-DOTAGA-Glu (FAPi) 2 Shows Enhanced Tumor Uptake and Theranostic Potential in Preclinical PET Imaging[J]. Diagnostics, 2024, 14(18): 2024.

NH2-UAMC1110 TFA是一种UAMC1110衍生物，能够用于FAPI-QS的合成。UAMC1110是一种成纤维细胞激活蛋白（FAP）抑制剂，FAP是一种脯氨酸选择性丝氨酸蛋白酶，在肿瘤间质和许多其他以组织重塑为特征的疾病的病变中过表达^{[1, 2]}。FAPI-QS是一种螯合剂，可用于合成高肿瘤选择性和高剂量的放射性示踪剂，用于肿瘤的诊断和治疗^[3]。