Nandrolone phenylpropionate
(Synonyms: 苯丙酸诺龙) 目录号 : GC63096
Nandrolone phenylpropionate，19-nortestosterone 的衍生物，是一种合成代谢类固醇，可促进蛋白质合成。Nandrolone phenylpropionate 用于缓解组织分解代谢，可以用于骨质疏松症和特纳综合征的研究。
Cas No.:62-90-8
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >99.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Nandrolone phenylpropionate, a 19-nor-testosterone derivative, is an anabolic steroid that promotes protein synthesis. Nandrolone phenylpropionate alleviates tissue catabolism and can be used for osteoporosis and Turner syndrome research[1][2].
Nandrolone phenylpropionate (4.0 mg/kg/d; daily; for 14 days) treatment significantly increases the weight gain of rats. Nandrolone phenylpropionate treatment increases the mixed muscle protein fractional synthetic rate (FSR). And the muscle free cathepsin D activity is significantly increased by Nandrolone phenylpropionate treatment, indicating increased muscle protein degradation, total cathepsin D activity is unchanged[1].
[1]. N W Dumelow, et al. Effect of nandrolone phenylpropionate on protein metabolism in rats. Horm Metab Res. 1985 Aug;17(8):431.
[2]. K Noda, et al. Effects of the anabolic steroid nandrolone phenylpropionate on craniofacial growth in rats. J Morphol. 1994 Apr;220(1):25-33.
| Cas No. | 62-90-8 | SDF | |
| 别名 | 苯丙酸诺龙 | ||
| 分子式 | C27H34O3 | 分子量 | 406.56 |
| 溶解度 | DMSO : 100 mg/mL (245.97 mM; Need ultrasonic) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.4597 mL | 12.2983 mL | 24.5966 mL |
| 5 mM | 0.4919 mL | 2.4597 mL | 4.9193 mL |
| 10 mM | 0.246 mL | 1.2298 mL | 2.4597 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Benzyne-Mediated Esterification Reaction
Org Lett 2021 Sep 17;23(18):7274-7278.PMID:34498880DOI:10.1021/acs.orglett.1c02702.
A benzyne-mediated esterification of carboxylic acids and alcohols under mild conditions has been realized, which is made possible via a selective nucleophilic addition of carboxylic acid to benzyne in the presence of alcohol. After a subsequent transesterification with alcohol, the corresponding esters can be produced efficiently. This benzyne-mediated protocol can be used on the modification of Ibuprofen, cholesterol, estradiol, and synthesis of Nandrolone phenylpropionate. In addition, benzyne can also be used to promote lactonization and amidation reaction.
Effects of Nandrolone phenylpropionate in the horse: (2) general effects in animals undergoing training
Equine Vet J 1982 Jul;14(3):224-8.PMID:7106086DOI:10.1111/j.2042-3306.1982.tb02400.x.
The effect of 11 weekly injections of Nandrolone phenylpropionate (400 mg) was investigated by a crossover trial (2 training periods) in 6 Thoroughbred geldings undergoing training. A decrease in body weight and flank measurement occurred only during the first training period and was not modified by the anabolic steroid. Urinary nitrogen excretion was lower in the anabolic treated animals only in the first training period. Neither training nor training plus Nandrolone phenylpropionate administration caused any marked alteration in blood biochemistry or haematology. A significant decrease in plasma chloride and increase in haematocrit occurred independent of treatment in the latter, more extensive anaerobic training of both parts of the crossover. No change in urinary pH or specific gravity was found throughout the study. No evidence of improved racing performance due to Nandrolone phenylpropionate administration was observed. Behavioural changes attributed to the drug could be detected for at least 6 weeks after the cessation of treatment.
Effects of Nandrolone phenylpropionate in the horse: (3) skeletal muscle composition in the exercising animal
Equine Vet J 1982 Jul;14(3):229-33.PMID:7106087DOI:10.1111/j.2042-3306.1982.tb02402.x.
The effect of 11 weekly injections of Nandrolone phenylpropionate (400 mg) on some skeletal muscle parameters was investigated in 6 Thoroughbred geldings undergoing training. Three muscles were sampled, the middle gluteal, the biceps femoris and the semitendinosus. Training alone produced increases in the percentage of fast twitch high oxidative fibres (FTH), glycogen content and the activities of citrate synthase, 3-hydroxyacl CoA dehydrogenase and cytochrome oxidase. In contrast the training programme did not alter water content, total protein content, the activities of lactate dehydrogenase, phosphofructokinase of beta glucuronidase, fibre area ratios or the number of capillaries per unit fibre area. Nandrolone phenylpropionate given in conjunction with the training programme only resulted in changes in 2 of these parameters. There was no increase in the percentage of FTH fibres in the biceps femoris with anaerobic training and the fibre area ratio increased significantly in this muscle.
Effects of the anabolic steroid Nandrolone phenylpropionate on craniofacial growth in rats
J Morphol 1994 Apr;220(1):25-33.PMID:8021946DOI:10.1002/jmor.1052200104.
Primary testosterone and its derivatives are anabolic steroids used in the treatment of osteoporosis and Turner syndrome. They also enhance fast-twitch muscle weight in female rats. The present study examines the effect of an anabolic steroid on craniofacial growth and development in rats. Five-week-old female Sprague-Dawley rats (125) were divided into experimental and control groups. The experimental group was injected subcutaneously with 1 mg Nandrolone phenylpropionate in the interscapular region on alternate days, whereas those in the control group were injected with a vehicle, arachis oil. Rats were sacrificed at 60 and 120 days of age. Cephalometric analysis of soft X-ray cephalograms showed that chronic administration of the anabolic steroid, Nandrolone phenylpropionate, resulted in: (1) about a 20% increase in body weight, (2) an increase in total skull length, (3) elongation of the maxillary and mandibular incisors, (4) an increase in the depth of the antegonial notch, and (5) downward-forward growth of the viscerocranium against the neurocranium. These results suggest that Nandrolone phenylpropionate may accelerate craniofacial growth and/or induce high functional activity of the masticatory muscles in female rats.
Effects of Nandrolone phenylpropionate in the horse: (1) resting animal
Equine Vet J 1982 Jul;14(3):219-23.PMID:7106085DOI:10.1111/j.2042-3306.1982.tb02398.x.
The effects of 7 weekly injections of the anabolic steroid Nandrolone phenylpropionate (400 mg) were investigated in 4 healthy, mature geldings. Measurement of body weight, nitrogen retention and plasma urea failed to demonstrate a consistent anabolic effects. Examination of biopsies from the semitendinosus and biceps femoris muscles showed no alteration in water content or glycogen concentration with treatment. Similarly no changes were found in the activities of 6 muscle enzymes. However, a significant increase in the proportion of fast twitch low oxidative fibres of the biceps femoris was observed. The effects of the treatment on a wide range of plasma biochemical constituents were investigated. The occurrence of some components of stallion behaviour in the geldings was taken to reflect a residual androgenic activity in the compound.