N1-Methyladenosine-5’-Triphosphate
目录号 : GN20030
N1-Methyladenosine-5'-Triphosphate是一种合成的核苷三磷酸衍生物。
Sample solution is provided at 25 µL, 10mM.
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N1-Methyladenosine-5'-Triphosphate is a synthetic nucleoside triphosphate derivative [1]. N1-Methyladenosine-5’-Triphosphate is a methylated adenosine at the N1 position based on adenosine triphosphate (ATP) [2-3]. N1-Methyladenosine-5’-Triphosphate for the synthesis of mRNA with reduced immunogenicity and improved stability [4].
References:
[1]. Andries O, Mc Cafferty S, De Smedt SC, et al. N1-methylpseudouridine-incorporated mRNA outperforms pseudouridine-incorporated mRNA by providing enhanced protein expression and reduced immunogenicity in mammalian cell lines and mice. Journal of Controlled Release. 2015 Nov 10; 217: 337-344.
[2]. Francis L. The Roles of Endonucleolytic Cleavage in RNA Metabolism and Transcriptional Termination. University of Exeter (United Kingdom); 2019.
[3]. Morena F, Argentati C, Bazzucchi M, et al. Above the epitranscriptome: RNA modifications and stem cell identity. Genes. 2018 Jun 28; 9(7): 329.
[4]. Li D, Bian L, Cui L, et al. Heterologous Prime-Boost Immunization Strategies Using Varicella-Zoster Virus gE mRNA Vaccine and Adjuvanted Protein Subunit Vaccine Triggered Superior Cell Immune Response in Middle-Aged Mice. International Journal of Nanomedicine. 2024 Dec 31: 8029-8042.
N1-Methyladenosine-5'-Triphosphate是一种合成的核苷三磷酸衍生物 [1]。N1-Methyladenosine-5’-Triphosphate是基于三磷酸腺苷（ATP）在N1位甲基化的腺苷 [2-3]。N1-Methyladenosine-5’-Triphosphate用于合成具有降低免疫原性和提高稳定性的mRNA [4].
| purity | >90.00% | Extinction Coefficient | 14,600 Lmol-1cm-1 at 257 nm |
| 分子式 | C11H18N5O13P3 (free acid) | 分子量 | 521.20 g/mole (free acid) |
| Salt Form | Li+ | Concentration | 100 mM |
| Buffer | H2O | 储存条件 | -20°C or below |
| Synonyms | N1-Methyl-ATP | Backbone | 5'-Triphosphate |
| Base Analog | Adenosine | Sugar Type | RNA |
| Nucleotide Category | Base Modified RNA | ||
| Applications | Aptamers, Epigenetics/DNA Damage, In vitro Transcription, Mutagenesis, Photocrosslinking Studies | ||