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Lamotrigine-d3 Sale

(Synonyms: 拉莫三嗪-[D3]) 目录号 : GC52020

An internal standard for the quantification of lamotrigine

Lamotrigine-d3 Chemical Structure

Cas No.:1132746-94-1

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1 mg
¥2,364.00
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5 mg
¥10,643.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

Lamotrigine-d3 is intended for use as an internal standard for the quantification of lamotrigine by GC- or LC-MS. Lamotrigine is an anticonvulsant.1 It inhibits voltage-gated sodium channels (Nav) in HEK293 cells expressing recombinant human Nav1.2, Nav1.5, or Nav1.8 (IC50s = 10, 62, and 96 μM, respectively), as well as high voltage-activated calcium currents in isolated rat cortical neurons (IC50 = 12.3 µM), an effect that can be reversed by the N-type calcium channel blocker ω-conotoxin GVIA and P-type calcium channel blocker ω-agatoxin IVA .1,2 Lamotrigine protects against seizures induced by maximal electroshock (MES) in mice and rats (ED50s = 10.1 and 7.4 µmol/kg, respectively).3 It also decreases mechanical allodynia in a rat model of neuropathic pain induced by spinal nerve ligation (ED50 = 47 µmol/kg).1 Formulations containing lamotrigine have been used in the treatment of epilepsy and bipolar disorder.

1.Drizin, I., Gregg, R.J., Scanio, M.J., et al.Discovery of potent furan piperazine sodium channel blockers for treatment of neuropathic painBioorg. Med. Chem.16(12)6379-6386(2008) 2.Stefani, A., Spadoni, F., Siniscalchi, A., et al.Lamotrigine inhibits Ca2+ currents in cortical neurons: Functional implicationsEur. J. Pharmacol.307(1)113-116(1996) 3.Miller, A.A., Wheatley, P., Sawyer, D.A., et al.Pharmacological studies on lamotrigine, a novel potential antiepileptic drug: I. Anticonvulsant profile in mice and ratsEpilepsia27(5)483-489(1986)

Chemical Properties

Cas No. 1132746-94-1 SDF Download SDF
别名 拉莫三嗪-[D3]
Canonical SMILES NC1=NC(N)=NN=C1C2=C(C(Cl)=C([2H])C([2H])=C2[2H])Cl
分子式 C9H4Cl2D3N5 分子量 259.1
溶解度 Ethanol: 25 mg/ml 储存条件 -20°C
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1 mg 5 mg 10 mg
1 mM 3.8595 mL 19.2976 mL 38.5951 mL
5 mM 0.7719 mL 3.8595 mL 7.719 mL
10 mM 0.386 mL 1.9298 mL 3.8595 mL
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