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JBIR-15 Sale

目录号 : GC43927

JBIR-15 是一种新的天冬青素衍生物。

JBIR-15 Chemical Structure

Cas No.:1198588-57-6

规格 价格 库存 购买数量
250μg
¥2,141.00
现货
1mg
¥7,709.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

JBIR-15 is a fungal metabolite produced by A. sclerotiorum. It has antifungal activity against C. albicans (MIC = 30 μM) but has no observable antibacterial activity against E. coli and S. aureus or cytotoxicity against HL-60 and A549 cells.

Chemical Properties

Cas No. 1198588-57-6 SDF
Canonical SMILES O=C(/C=C/C=C/C=C/C)N[C@@H](CCCNC([C@H](C)N1)=O)C(N(C)[C@@H](C(C)C)C1=O)=O
分子式 C22H34N4O4 分子量 418.5
溶解度 Soluble in DMSO 储存条件 Store at -20°C
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1 mg 5 mg 10 mg
1 mM 2.3895 mL 11.9474 mL 23.8949 mL
5 mM 0.4779 mL 2.3895 mL 4.779 mL
10 mM 0.2389 mL 1.1947 mL 2.3895 mL
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Research Update

JBIR-15, a new aspochracin derivative, isolated from a sponge-derived fungus, Aspergillus sclerotiorum Huber Sp080903f04

Biosci Biotechnol Biochem 2009 Aug;73(8):1898-900.PMID:19661713DOI:10.1271/bbb.90228.

In the course of our chemical screening program for novel metabolites by LC-MS monitoring, we isolated a new aspochracin derivative, JBIR-15 (1), together with aspochracin, from the culture broth of a sponge-derived fungus, Aspergillus sclerotiorum Huber Sp080903f04. The structure of 1 was determined to be N-demethyl aspochracin at the alanyl residue on the basis of extensive NMR and MS analyses.

Cyclic tripeptides from the halotolerant fungus Aspergillus sclerotiorum PT06-1

J Nat Prod 2010 Jun 25;73(6):1133-7.PMID:20503985DOI:10.1021/np100198h.

Eleven new aspochracin-type cyclic tripeptides, sclerotiotides A-K (1-11), together with three known compounds, JBIR-15 (12), aspochracin (13), and penicillic acid, were isolated from the ethyl acetate extract of the fermentation broth of the halotolerant Aspergillus sclerotiorum PT06-1 in a hypersaline nutrient-rich medium. Their structures were elucidated by spectroscopic analysis and chemical methods. Chemical transformations of 12 and 13 proved that sclerotiotides D-K (4-11) were artifacts probably formed during the fermentation or subsequent isolation steps. All 13 cyclic tripeptides have been evaluated for their antimicrobial and cytotoxic effects. Only sclerotiotides A (1), B (2), F (6), and I (9) and JBIR-15 (12) showed selective antifungal activity against Candida albicans with MIC values of 7.5, 3.8, 30, 6.7, and 30 microM, respectively.