Isothipendyl (hydrochloride)
(Synonyms: 盐酸异西喷他) 目录号 : GC48752
An antihistamine
Cas No.:1225-60-1
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Isothipendyl is an antihistamine.1 It protects against seizures induced by supramaximal electroshock (MES) in rats (ED50 = 57.9 mg/kg). Formulations containing isothipendyl have been used in the treatment of itching associated with insect bites.
1.Saxena, V.C., Bapat, S.K., and Dhawan, B.N.An experimental evaluation of the anticonvulsant activity of some antihistaminic drugsJpn. J. Pharmacol.19(4)477-484(1969)
| Cas No. | 1225-60-1 | SDF | |
| 别名 | 盐酸异西喷他 | ||
| Canonical SMILES | CN(C)C(C)CN1C2=C(C=CC=C2)SC3=CC=CN=C13.Cl | ||
| 分子式 | C16H19N3S•HCl | 分子量 | 321.9 |
| 溶解度 | DMSO: soluble | 储存条件 | -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.1066 mL | 15.5328 mL | 31.0655 mL |
| 5 mM | 0.6213 mL | 3.1066 mL | 6.2131 mL |
| 10 mM | 0.3107 mL | 1.5533 mL | 3.1066 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Photodermatitis from topical phenothiazines: A case series
Contact Dermatitis 2020 Jul;83(1):19-24.PMID:32124458DOI:10.1111/cod.13509.
Background: In Europe, contact photosensitivity to phenothiazines is well-known, particularly in southern countries. Topical phenothiazines are widely used and sold over-the-counter (OTC) for the treatment of mosquito bites and pruritus in France. Objective: To report a series of cases with photodermatitis following use of topical phenothiazines. Method: A retrospective study of cases of contact dermatitis from phenothiazines seen in French photodermatology centers was performed. Results: In all, 14 patients with a diagnosis of contact dermatitis from phenothiazines were included. These patients developed eczema on the application sites, and in 13 the eruption spread to photodistributed sites. Topical products containing Isothipendyl were the most common cause of photodermatitis. One patient had photoaggravated eczema due to promethazine cream. All patients stopped using topical phenothiazines and were treated successfully with topical corticosteroids. One patient relapsed and developed persistent light eruption. In all of the nine cases tested, photopatch testing to the topical phenothiazine used "as is" was positive. Isothipendyl, chlorproethazine, and the excipients were not tested. Photopatch tests to chlorpromazine and promethazine were positive in 8 of 12 and 7 of 13 tested, respectively. Conclusion: Use of Isothipendyl and promethazine as OTC (or even prescribed) drugs needs to be limited due to severe reactions and sensitization to other phenothiazines that consequently will have to be avoided.
Contact photoallergy to Isothipendyl chlorhydrate
Dermatology 2012;224(4):289-91.PMID:22677929DOI:10.1159/000338024.
Isothipendyl chlorhydrate is an azaphenothiazine, an active ingredient of an antipruriginous gel, Apaisyl gel® (Merck Médication Familiale, Dijon, France). Although Apaisyl gel is registered and used worldwide, we present the first case of contact photoallergy to Isothipendyl chlorhydrate to our knowledge. The diagnosis suspected on the basis of a positive UVA photopatch test to chlorpromazine was confirmed by a strongly positive UVA Apaisyl gel photopatch test and our photophysical studies. This case confirms the need to keep the phenothiazines in the photopatch test standard series as a diagnostic marker of phenothiazine photoallergy.
Determination of Isothipendyl or dimethothiazine with their sulphoxides using third- and fourth-derivatives spectroscopy on a diode-array spectrophotometer
J Pharm Belg 1990 Jul-Aug;45(4):259-67.PMID:2290121doi
Third- and fourth-derivative spectrophotometry (3D + 4D), with a diode-array spectrophotometer, has been used for the assay of mixtures of each of Isothipendyl hydrochloride (I) and its sulphoxide (II) or dimethothiazine mesylate (III) and its sulphoxide (IV). The parent compounds have been determined by measuring the 3D at 256 nm, 246-256 nm and 256-264 nm and 4D at 250 nm for (I) and 3D at 255 nm or 283 nm and 4D at 257 nm for (III). The sulphoxides have been assayed by measuring the 3D at 285-290 nm and 4D 285-290 nm for (II) and 3D at 305 nm and 4D at 303-310 nm for (IV). Beer's law is obeyed and the detection limits for the proposed 3D and 4D has been calculated. The recovery of these drugs and their sulphoxides in laboratory-made mixture and dosage forms has been reported.
Phototoxic and photoprotective effects of topical Isothipendyl
Photodermatol Photoimmunol Photomed 1995 Apr;11(2):50-4.PMID:8546983DOI:10.1111/j.1600-0781.1995.tb00139.x.
Isothipendyl, an H1-receptor antagonist, is an antihistamine used as an antiallergic drug. Its molecular structure is close to the phenothiazines, but it has different photobiological properties. Like phenothiazines, Isothipendyl is phototoxic with ultraviolet A (UVA) but it reduces the erythema response to UVB radiation. Isothipenyl seems to have the same protective properties as a sunscreen because its UVB protective properties are effective only if the substance is applied prior to exposure.
Spectrophotometric studies on the investigation of chromium in environmental samples
Indian J Environ Health 2003 Jan;45(1):25-8.PMID:14723280doi
Isothipendyl hydrochloride is proposed as a sensitive and selective reagent for the rapid spectrophotometric determination of chromium(VI). The reagent instantaneously gives a red coloured species on reaction with chromium(VI) in phosphoric acid medium which exhibits maximum absorbance at 510 nm with Sandell's sensitivity of 2.28 ng cm(-2). Beer's law is valid over the concentraction range of 0.1-1.9 mg/l with an optimum concentration range of 0.2-1.7 mg/l. The method has been successfully applied to the analysis of chromium in environmental samples.