Ibafloxacine (R835)
(Synonyms: 依巴沙星; R835; S25930) 目录号 : GC33988
Ibafloxacine (R835) (R835) 是一种专门为兽医使用而开发的氟喹诺酮类抗生素。
Cas No.:91618-36-9
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Animal experiment: | Goats[1]Six Murciano-Granadina female goats 52 to 58 kg in body weight (BW) and 3 to 4 y of age are used. A 5% aqueous solution of Ibafloxacin is prepared from the pure substance and sterilized. The solution is administered by the IV route as a single dose of 15 mg/kg BW. Blood samples (4 mL) are collected from the contralateral jugular vein into heparinized tubes at 0, 5, 10, 15, 30, and 45 min and at 1, 1.5, 2, 4, 6, 8, 10, 12, 24, 32, 48, and 72 h after drug administration. The samples are centrifuged at 1500× g for 15 min, and then the plasma is removed and stored at -45°C until assayed. Milk samples are collected before and at 1, 2, 4, 6, 12, 24, 32, 48, and 72 h after complete evacuation of the udder at each collection period. The concentration of Ibafloxacin is measured in plasma and milk by a modified high-performance liquid chromatography (HPLC) method. |
References: [1]. Marín P, et al. Pharmacokinetics and milk penetration of ibafloxacin after intravenous administration to lactating goats. Can J Vet Res. 2007 Jan;71(1):74-6. | |
Ibafloxacine (R835) is a fluoroquinolone antibiotic agent that is developed exclusively for veterinary use.
The pharmacokinetic behavior of Ibafloxacin is studied after intravenous administration of a single dose of 15 mg/kg to 6 healthy lactating goats. Plasma concentrations of Ibafloxacin are determined by high-performance liquid chromatography with fluorescence detection. After IV injection Ibafloxacin shows very rapid initial distribution, with a mean half-life of 0.35 h, follows by slower elimination, with a mean half-life of 3.76 h. The elimination half-life of Ibafloxacin after oral administration has been reported to be 3.83 h in dogs and 3.00 h in cats[1].
[1]. Marín P, et al. Pharmacokinetics and milk penetration of ibafloxacin after intravenous administration to lactating goats. Can J Vet Res. 2007 Jan;71(1):74-6.
| Cas No. | 91618-36-9 | SDF | |
| 别名 | 依巴沙星; R835; S25930 | ||
| Canonical SMILES | O=C(C1=CN2C(C)CCC3=C2C(C1=O)=CC(F)=C3C)O | ||
| 分子式 | C15H14FNO3 | 分子量 | 275.27 |
| 溶解度 | Soluble in DMSO | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 3.6328 mL | 18.164 mL | 36.328 mL |
| 5 mM | 0.7266 mL | 3.6328 mL | 7.2656 mL |
| 10 mM | 0.3633 mL | 1.8164 mL | 3.6328 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。