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Himandridine Sale

(Synonyms: NSC 23972) 目录号 : GC46156

An alkaloid

Himandridine Chemical Structure

Cas No.:15521-76-3

规格 价格 库存 购买数量
500μg
¥2,723.00
现货
2.5mg
¥11,580.00
现货

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Sample solution is provided at 25 µL, 10mM.

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产品描述

Himandridine is an alkaloid that has been found in Galbulimima.1

|1. Mander, L.N., Ritchie, E., and Taylor, W.C. The chemical constituents of Galbulimima species. VI. The structure of himandridine. Aust. J. Chem. 20(5), 981-1019 (1967).

Chemical Properties

Cas No. 15521-76-3 SDF
别名 NSC 23972
Canonical SMILES O[C@]1([C@]2([H])CC3)C([C@@]([C@@](CC[C@@H]4O)([H])[C@]([C@H]4OC)([H])[C@@H]5OC(C6=CC=CC=C6)=O)(N([C@H]3C)[C@]2([H])C7)C7C1)=C5C(OC)=O
分子式 C30H37NO7 分子量 523.6
溶解度 Soluble in DMSO 储存条件 Store at -20°C
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 1.9099 mL 9.5493 mL 19.0985 mL
5 mM 0.382 mL 1.9099 mL 3.8197 mL
10 mM 0.191 mL 0.9549 mL 1.9099 mL
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Research Update

Progress toward the syntheses of (+)-GB 13, (+)-himgaline, and Himandridine. new insights into intramolecular imine/enamine aldol cyclizations

J Am Chem Soc 2012 May 16;134(19):8162-70.PMID:22533781DOI:10.1021/ja3001776

A full account of our total synthesis of the galbulimima alkaloids GB 13 and himgaline is provided. Using a strategy adapted from the proposed biosynthesis of the GB alkaloid family, a linear precursor underwent successive intramolecular Diels-Alder, Michael, and imine aldol cyclizations to form the polycyclic alkaloid core. We now show that modification of this strategy can also deliver an advanced intermediate en route to the related alkaloid Himandridine. The success of the key imine aldol cyclization is acutely sensitive to substrate structure and solvent, including a case in which cyclization was spontaneous in protic solvents. A detailed computational investigation of the course of the reaction closely correlates with, and suggests a rationale for, the observed patterns of imine aldol reactivity.