Heparin sodium (MW 3000-5000)

The specific biological function of heparin is achieved through the interaction between specific functional regions within its sugar chain and target proteins. For example, heparin molecules can inhibit factor Xa through the interaction between the special five sugar structure GlcNAc/NS (6S) - GlcA GlcNS (3S, 6S) - IdoA (2S) - GlcNS (6S) within the sugar chain and antithrombin ATIII. In order to meet the needs of customers for studying the structure-activity relationship of various glycosaminoglycans, we used heparanase I/II to partially degrade heparin, and prepared heparin oligosaccharides and low molecules with different polymerization degrees through gel filtration and ion exchange HPLC.

肝素的具体生物学功能是通过其糖链内部特定结构的功能区与靶蛋白的相互作用来实现的，如肝素分子可以通过糖链内部的特殊的五糖结构GlcNAc/NS(6S)-GlcA-GlcNS(3S,6S)-IdoA(2S)-GlcNS(6S)与抗凝血酶ATIII的相互作用介导对因子Xa的抑制。为了满足客户对各种糖胺聚糖构效关系研究的需要，我们利用肝素酶I/II对肝素进行部分降解，通过凝胶过滤及离子交换HPLC，制备了具有不同聚合度的肝素寡糖及低分子。