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H-Arg-OH.HCl Sale

(Synonyms: L-精氨酸盐酸盐,(S)-(+)-Arginine hydrochloride) 目录号 : GA11127

H-Arg-OH.HCl ((S)-(+)-Arginine hydrochloride) 是合成一氧化氮的氮供体,一氧化氮是一种在镰状细胞危机期间缺乏的强效血管扩张剂。

H-Arg-OH.HCl Chemical Structure

Cas No.:1119-34-2

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Sample solution is provided at 25 µL, 10mM.

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产品描述

L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.

Arginine is an α-amino acid. The L-form is one of the 20 most common natural amino acids. At the level of molecular genetics, in the structure of the messenger ribonucleic acid mRNA, CGU, CGC, CGA, CGG, AGA, and AGG, are the triplets of nucleotide bases or codons that code for arginine during protein synthesis. In mammals, arginine is classified as a semiessential or conditionally essential amino acid, depending on the developmental stage and health status of the individual.L-Arginine is associated with a decrease in cardiac index while stroke index is maintained in patients with severe sepsis. Resolution of shock at 72 hours is achieved by 40% and 24% of the patients in the L-Arginine and placebo cohorts, respectively. L-Arginine (450 mg/kg during a 15-minute period) amplifies and sustains the hyperemia (38%) and increases absolute brain blood flow after eNOS upregulation by chronic simvastatin treatment (2 mg/kg subcutaneously, daily for 14 days) in SV-129 mice.

References:
[1]. Tapiero H, et al. I. Arginine. Biomed Pharmacother. 2002 Nov;56(9):439-45.
[2]. Bakker J, et al. Administration of the nitric oxide synthase inhibitor NG-methyl-L-arginine hydrochloride (546C88) by intravenous infusion for up to 72 hours can promote the resolution of shock in patients with severe sepsis: results of a randomized, double-blind, placebo-controlled multicenter study (study no. 144-002). Crit Care Med. 2004 Jan;32(1):1-12.
[3]. Yamada M, et al. Endothelial nitric oxide synthase-dependent cerebral blood flow augmentation by L-arginine after chronic statin treatment. J Cereb Blood Flow Metab. 2000 Apr;20(4):709-17.

Chemical Properties

Cas No. 1119-34-2 SDF
别名 L-精氨酸盐酸盐,(S)-(+)-Arginine hydrochloride
化学名 (2S)-2-amino-5-(diaminomethylideneamino)pentanoic acid;hydrochloride
Canonical SMILES C(CC(C(=O)O)N)CN=C(N)N.Cl
分子式 C6H14N4O2.HCl 分子量 210.7
溶解度 DMF: 5 mg/ml,DMSO: 3 mg/ml,Ethanol: 3 mg/ml,PBS (pH 7.2): freely soluble 储存条件 Store at 2-8°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 4.7461 mL 23.7304 mL 47.4608 mL
5 mM 0.9492 mL 4.7461 mL 9.4922 mL
10 mM 0.4746 mL 2.373 mL 4.7461 mL
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