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Glycodeoxycholic acid monohydrate

(Synonyms: 甘氨脱氧胆酸(一水),GDCA) 目录号 : GC34176

A glycine-conjugated form of deoxycholic acid

Glycodeoxycholic acid monohydrate Chemical Structure

Cas No.:1079043-81-4

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥589.00
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100mg
¥536.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

Glycodeoxycholic acid (GDCA) is a glycine-conjugated form of the secondary bile acid deoxycholic acid .1 It induces a reversible, concentration-dependent reduction in myogenic tone in rats and decreases expression of the gene encoding the cytochrome P450 (CYP) isoform 7A1 (CYP7A1) in rabbits.2,3 Serum levels of GDCA are elevated in non-surviving patients with acetaminophen-induced acute liver failure (AALF) compared with survivors.4 GDCA levels are also increased in the plasma of patients with asthma.5

1.Lefebvre, P., Cariou, B., Lien, F., et al.Role of bile acids and bile acid receptors in metabolic regulationPhysiol. Rev.89(1)147-191(2009) 2.Khurana, S., Raina, H., Pappas, V., et al.Effects of deoxycholylglycine, a conjugated secondary bile acid, on myogenic tone and agonist-induced contraction in rat resistance arteriesPLoS One7(2)e32006(2012) 3.Shang, Q., Guo, G.L., Honda, A., et al.Bile acid flux through portal but not peripheral veins inhibits CYP7A1 expression without involvement of ileal FGF19 in rabbitsAm. J. Physiol. Gastrointest. Liver Physiol.307(4)G479-G486(2014) 4.Woolbright, B.L., McGill, M.R., Staggs, V.S., et al.Glycodeoxycholic acid levels as prognostic biomarker in acetaminophen-induced acute liver failure patientsToxicol. Sci.142(2)436-444(2014) 5.Comhair, S.A.A., McDunn, J., Bennett, C., et al.Metabolomic endotype of asthmaJ. Immunol.195(2)643-650(2015)

Chemical Properties

Cas No. 1079043-81-4 SDF
别名 甘氨脱氧胆酸(一水),GDCA
化学名 N-[(3α,5β,12α)-3,12-dihydroxy-24-oxocholan-24-yl]-glycine, monohydrate
Canonical SMILES O=C(O)CNC(CC[C@@H](C)[C@H]1CC[C@@]2([H])[C@]3([H])CC[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])C[C@H](O)[C@]12C)=O.O
分子式 C26H45NO6 分子量 467.64
溶解度 1 mg/ml in ethanol; 10 mg/ml in DMSO/DMF 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.1384 mL 10.692 mL 21.384 mL
5 mM 0.4277 mL 2.1384 mL 4.2768 mL
10 mM 0.2138 mL 1.0692 mL 2.1384 mL
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