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Glutaric acid-d6 Sale

(Synonyms: 戊二酸 d6) 目录号 : GC64471

Glutaric acid-d6 是 Glutaric acid 的氘代物。Glutaric acid,一种 C5 二羧酸,是赖氨酸和色氨酸分解代谢途径中的中间体。Glutaric acid 影响周细胞的收缩性和迁移。Glutaric acid 是 I 型戊二酸尿症的指标。

Glutaric acid-d6 Chemical Structure

Cas No.:154184-99-3

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10 mg
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25 mg
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50 mg
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Sample solution is provided at 25 µL, 10mM.

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产品描述

Glutaric acid-d6 is the deuterium labeled Glutaric acid. Glutaric acid is an intermediate during the catabolic pathways of lysine and tryptophan. Glutaric acid affects pericyte contractility and migration. Glutaric acid is an indicator of glutaric aciduria type I[1][2][3].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Yang SY, et, al. Production of glutaric acid from 5-aminovaleric acid by robust whole-cell immobilized with polyvinyl alcohol and polyethylene glycol. Enzyme Microb Technol. 2019 Sep;128:72-78.
[3]. Boy N, et, al. Proposed recommendations for diagnosing and managing individuals with glutaric aciduria type I: second revision. J Inherit Metab Dis. 2017 Jan;40(1):75-101.
[4]. Isasi E, et, al. Glutaric Acid Affects Pericyte Contractility and Migration: Possible Implications for GA-I Pathogenesis. Mol Neurobiol. 2019 Nov;56(11):7694-7707.

Chemical Properties

Cas No. 154184-99-3 SDF Download SDF
别名 戊二酸 d6
分子式 C5H2D6O4 分子量 138.15
溶解度 DMSO : 250 mg/mL (1809.63 mM; Need ultrasonic) 储存条件 Store at -20°C
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 7.2385 mL 36.1925 mL 72.3851 mL
5 mM 1.4477 mL 7.2385 mL 14.477 mL
10 mM 0.7239 mL 3.6193 mL 7.2385 mL
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