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Glutaric acid-d4

(Synonyms: 戊二酸 d4) 目录号 : GC69176

Glutaric acid-d4 是 Glutaric acid 的氘代物。Glutaric acid,一种 C5 二羧酸,是赖氨酸和色氨酸分解代谢途径中的中间体。Glutaric acid 影响周细胞的收缩性和迁移。Glutaric acid 是 I 型戊二酸尿症的指标。

Glutaric acid-d4 Chemical Structure

Cas No.:19136-99-3

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产品描述

Glutaric acid-d4 is the deuterium labeled Glutaric acid. Glutaric acid, C5 dicarboxylic acid, is an intermediate during the catabolic pathways of lysine and tryptophan. Glutaric acid affects pericyte contractility and migration. Glutaric acid is an indicator of glutaric aciduria type I[1][2][3].

Stable heavy isotopes of drogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
[2]. Yang SY, et, al. Production of glutaric acid from 5-aminovaleric acid by robust whole-cell immobilized with polyvinyl alcohol and polyetlene glycol. Enzyme Microb Technol. 2019 Sep;128:72-78.
[3]. Boy N, et, al. Proposed recommendations for diagnosing and managing individuals with glutaric aciduria type I: second revision. J Inherit Metab Dis. 2017 Jan;40(1):75-101.
[4]. Isasi E, et, al. Glutaric Acid Affects Pericyte Contractility and Migration: Possible Implications for GA-I Pathogenesis. Mol Neurobiol. 2019 Nov;56(11):7694-7707.

Chemical Properties

Cas No. 19136-99-3 SDF Download SDF
别名 戊二酸 d4
分子式 C5H4D4O4 分子量 136.14
溶解度 储存条件 Store at -20°C
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溶解性数据

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1 mM 7.3454 mL 36.7269 mL 73.4538 mL
5 mM 1.4691 mL 7.3454 mL 14.6908 mL
10 mM 0.7345 mL 3.6727 mL 7.3454 mL
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