Gloxazone
目录号 : GC69165Gloxazone是一种高效但具毒性的anaplasmacide。
Cas No.:2507-91-7
Sample solution is provided at 25 µL, 10mM.
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Gloxazone is an effective and toxic anaplasmacide[1]. Gloxazone has been widely used in the study of the immune responses of different animals to Cowdria ruminantium[2].
In vivo, Gloxazone treatment (10mg/kg/day; s.c.) for 14 days alleviated the parasitaemia in the steers and calves artificially infected with Anaplasma marginale[4]. Treatment with Gloxazone (i.v.) at a dose of 5mg/kg/day for 11days can alleviate the heartwater symptoms caused by infection with Cowdria within Balb/C mice[5].
References:
[1] McHardy N, Berger J, Taylor R J, et al. Comparison of gloxazone, an effective but toxic anaplasmacide, with imidocarb dihydrochloride[J]. Research in Veterinary Science, 1980, 29(2): 198-202.
[2] Todorovic R A, Lopez L A, Lopez A G, et al. Bovine babesiosis and anaplasmosis: Control by premunition and chemoprophylaxis[J]. Experimental parasitology, 1975, 37(1): 92-104.
[3] Kuttler K L. Current anaplasmosis control techniques in the United States[J]. Journal of the South African Veterinary Association, 1979, 50(4): 314-320.
[4] McHardy N. Serological responses to bovine anaplasmosis following treatment with gloxazone[J]. Veterinary Parasitology, 1980, 7(4): 287-296.
[5] McHardy N, Mackenzie P K. Virulence of two strains of Cowdria ruminantium in mice and their use to predict drug activity against heartwater[J]. Tropical Animal Health and Production, 1984, 16(1): 56-62.
Gloxazone是一种高效但具毒性的anaplasmacide[1]。Gloxazone广泛用于研究不同动物对Cowdria ruminantium的免疫反应[2-3]。
在体内，人工感染Anaplasma marginale的阉牛和犊牛经Gloxazone（10mg/kg/day；皮下注射）连续治疗14天后，寄生虫血症症状得到缓解[4]。静脉注射Gloxazone（5mg/kg/day）治疗11天，可减轻Balb/C小鼠因Cowdria感染引发的心水病临床症状[5]。
| Animal experiment [1]: | |
Animal models | Merino ewes (sheep) |
Preparation Method | Three strains of C. ruminantiumas were inoculated into 36 Merino ewes aged 6 to 12 months. One to two months after recovery from artificial infection, 18 sheep were intramuscularly injected with Gloxazone at a dose of 10mg/kg/day for three consecutive days, while the remaining 18 sheep were not administered as controls. Six months later, the blood of sheep infected with the 3 strain C. ruminantium was used to challenge 9 sheep treated with Gloxazone and 9 control sheep. On the second day of the fever reaction, 10 milliliters of heparinized blood was drawn from each animal that responded to the attack and inoculated into a susceptible sheep. After the sheep received Gloxazone treatment for 9 months, the above steps were repeated for another 8 sheep that received Gloxazone treatment and an equal number of control groups. |
Dosage form | 10mg/kg/day for 3 days; i.m. |
Applications | Gloxazone treatment can change the immunity of sheep to heartwater to a certain extent. |
References: | |
| Cas No. | 2507-91-7 | SDF | Download SDF |
| 分子式 | C8H16N6OS2 | 分子量 | 276.38 |
| 溶解度 | DMSO : 125 mg/mL (452.28 mM; ultrasonic and warming and heat to 60°C) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.6182 mL | 18.091 mL | 36.1821 mL |
| 5 mM | 0.7236 mL | 3.6182 mL | 7.2364 mL |
| 10 mM | 0.3618 mL | 1.8091 mL | 3.6182 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
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- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
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