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Germicidin B Sale

目录号 : GC16571

An autoregulative inhibitor of spore germination

Germicidin B Chemical Structure

Cas No.:150973-78-7

规格 价格 库存 购买数量
500µg
¥2,450.00
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产品描述

Germicidin is a pyranone antibiotic originally excreted by Streptomyces viridochromogenes NRRL B-1551. Germicidin has an inhibitory effect on the germination of its own arthrospores at a concentration as low as 200 pM (40 pg/ml). Higher concentrations of germicidin inhibited porcine Na+/K+-activated ATPase and retarded the germination of the cress Lepidium sativum with an ID50 of 100 μM. Germicidin was the first known autoregulative inhibitor of spore germination in the genus Streptomyces and was isolated from the supernatant of germinated spores, but also from the supernatant of the submerged culture [1].

Germicidins B inhibited germination of S. coelicolor A3(2) spores above 1 μg/ml. The S. coelicolor A3(2) spores collected from a single petri dish (9 cm i.d.) contained 5.4 μg of germicidin A (~2.7 × 10-14 g per spore) and contents of germicidins B, C and D were 0.2–0.8 μg. The activity of the spore extract corresponded well with the sum of the activity of each germicidin. Germicidins functioned as self-germination inhibitors in S. coelicolor A3(2) [2].

References:
[1] PETERSEN F, ZHNER H, METZGER J W, et al.  Germicidin, an autoregulative germination inhibitor of Streptomyces viridochromogenes NRRL B-1551[J]. The Journal of antibiotics, 1993, 46(7): 1126-1138.
[2] Aoki Y, Matsumoto D, Kawaide H, et al.  Physiological role of germicidins in spore germination and hyphal elongation in Streptomyces coelicolor A3 (2)[J]. The Journal of antibiotics, 2011, 64(9): 607-611.

Chemical Properties

Cas No. 150973-78-7 SDF
化学名 3-ethyl-4-hydroxy-6-(1-methylethyl)-2H-pyran-2-one
Canonical SMILES O=C1OC(C(C)C)=CC(O)=C1CC
分子式 C10H14O3 分子量 182.2
溶解度 DMF: Soluble,DMSO: Soluble,Ethanol: Soluble,Methanol: Soluble 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

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1 mg 5 mg 10 mg
1 mM 5.4885 mL 27.4424 mL 54.8847 mL
5 mM 1.0977 mL 5.4885 mL 10.9769 mL
10 mM 0.5488 mL 2.7442 mL 5.4885 mL
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