Stigmastanol
(Synonyms: 豆甾烷醇) 目录号 : GD21338Stigmastanol是一种饱和的天然植物甾醇，属于植物甾醇类化合物，化学结构与胆固醇相似。
Cas No.:19466-47-8
Sample solution is provided at 25 µL, 10mM.
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Stigmastanol is a saturated form of natural phytosterols, belonging to the phytosterol class of compounds, with a chemical structure similar to cholesterol [1]. Stigmastanol can lower blood lipids by inhibiting cholesterol absorption [2]. Stigmastanol is often used in functional foods for preventing and treating hypercholesterolemia [3].
In PC12 cells, Stigmastanol (1µM, 2µM, 3µM, 4µM, 5µM, 10µM; 24h) inhibited D-gal-induced cell apoptosis [4].
In sprague-dawley rat models, Stigmastanol (50mg/kg; po; single administered) significantly inhibited intestinal cholesterol absorption after oral administration [5].
References:
[1]. Pinhas H, Loiseau A, Krikorian-Manoukian A, et al. 6-Amino derivatives of stigmastanol and cholestanol. Journal of Medicinal Chemistry. 1971 Nov; 14(11): 1048-1049.
[2]. Vahouny GV, Connor WE, Habiger RG, et al. Influence of stigmastanol and stigmastanyl-phosphorylcholine, two plasma cholesterol lowering substances, on synthetic phospholipid membranes. A 2H-and 31P-NMR study. Biochimica et Biophysica Acta (BBA)-Biomembranes. 1992 Jan 10; 1103(1): 69-76.
[3]. Gupta E. β-Sitosterol: Predominant phytosterol of therapeutic potential. Innovations in food technology: current perspectives and future goals. 2020:465-477.
[4]. Zhang Y, Xu D, Zhang X, et al. Rice bran oil rescues cognitive decline in D-galactose-induced aging mice by inhibiting Aβ accumulation and Tau hyperphosphorylation induced oxidative stress and neuroinflammation. Food Science and Human Wellness. 2025 Jul 1; 14(7).
[5]. Gershkovich P, Darlington J, Sivak O, et al. Inhibition of intestinal absorption of cholesterol by surface-modified nanostructured aluminosilicate compounds. Journal of pharmaceutical sciences. 2009 Jul 1; 98(7): 2390-2400.
Stigmastanol是一种饱和的天然植物甾醇，属于植物甾醇类化合物，化学结构与胆固醇相似 [1]。Stigmastanol可以通过抑制胆固醇吸收来降低血脂 [2]。Stigmastanol常用于功能性食品中，用于预防和治疗高胆固醇血症 [3]。
在PC12细胞中，Stigmastanol（1µM, 2µM, 3µM, 4µM, 5µM, 10µM; 24h）抑制了D-半乳糖诱导的细胞凋亡 [4]。
在Sprague-Dawley大鼠模型中，口服Stigmastanol（50mg/kg；po；单次给药）后显著抑制肠道胆固醇吸收 [5]。
| Cell experiment [1]: | |
Cell lines | PC12 cells |
Preparation Method | The PC12 cells were seeded into a 96-well plate (1 × 105 cells/well). After 6h of incubation, the cells were treated with different concentrations of D-gal, α-linolenic acid, Stigmastanol, D-gal/α-linolenic acid, and D-gal/Stigmastanol for 24h. Cell viability for each group was assessed using the MTT assay. |
Reaction Conditions | 1µM, 2µM, 3µM, 4µM, 5µM, 10µM; 24h |
Applications | Stigmastanol inhibited D-gal-induced PC12 cells apoptosis. |
| Animal experiment [2]: | |
Animal models | Sprague-Dawley rat models |
Preparation Method | The solid food was withheld but a free access to oral liquid cholesterol-free diet consisting of 5% glucose in lactated Ringer’s was allowed following the surgery and throughout the experiment. Twenty-four hours postsurgery, animals were divided into the following 10 treatment groups: nonpurified nanostructured aluminosilicate (NSAS) 50mg/kg; sodium NSAS 50mg/kg; protonated (by ion-exchange column) NSAS 20, 50, and 100mg/kg; hydrochloric acid-treated NSAS 50mg/kg; back-converted to sodium form (by NaOH) NSAS 50mg/kg; Stigmastanol 50mg/kg; ezetimibe 10mg/kg; and normal saline (control). All compounds were administered by oral gavage. |
Dosage form | 50mg/kg; po; single administered |
Applications | Stigmastanol significantly inhibited intestinal cholesterol absorption after oral administration. |
References: | |
| Cas No. | 19466-47-8 | SDF | |
| 别名 | 豆甾烷醇 | ||
| 分子式 | C29H52O | 分子量 | 416.72 |
| 溶解度 | 储存条件 | Store at 2-8°C | |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.3997 mL | 11.9985 mL | 23.9969 mL |
| 5 mM | 0.4799 mL | 2.3997 mL | 4.7994 mL |
| 10 mM | 0.24 mL | 1.1998 mL | 2.3997 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet