Lithium aluminum deuteride

Lithium aluminum deuteride is a material applied in isotype labeling, deuterium exchange reactions, deuterium isotope effects, substrate for chemical synthesis (including organometallic compounds).

In isotype labeling, lithium aluminum deuteride(1.0M THF solution; 4.0mL; 4.0mmol) reduce [13C15N]benzo[b]thiophene-3-carbonitrile to give [13CD215N]benzo[b]thiophen-3-yl-methylamine stable isotope-labeled compound with four stable isotope atoms^[1]. Lithium aluminum deuteride is also used for novel cage oxaheterocycles synthesis (155mg, 4.08mmol in dry THF (20mL)) and deuterium-labeled analogs of the lipid hydroperoxide-derived bifunctional electrophile 4-oxo-2(*E*)-nonenal synthesis as a deuteride donor^[2,3].

References:
[1] Lin, Ronghui et al. “Expeditious syntheses of stable and radioactive isotope-labeled anticonvulsant agent, JNJ-26990990, and its metabolites.” *Journal of labelled compounds & radiopharmaceuticals* vol. 56,1 (2013): 22-6. doi:10.1002/jlcr.3013
[2] Marchand, A P et al. “Synthesis of novel cage oxaheterocycles.” *The Journal of organic chemistry*vol. 66,6 (2001): 2072-7. doi:10.1021/jo001611c
[3] Arora, Jasbir S et al. “Synthesis of deuterium-labeled analogs of the lipid hydroperoxide-derived bifunctional electrophile 4-oxo-2(*E*)-nonenal.” *Journal of labelled compounds & radiopharmaceuticals* vol. 54,5 (2011): 247-251. doi:10.1002/jlcr.1860

Lithium aluminum deuteride氘化铝锂是一种应用于同型标记、氘交换反应、氘同位素效应、化学合成（包括有机金属化合物）底物的材料。

在同型标记中，氘化铝锂(1.0M THF溶液; 4.0毫升; 4.0mmol)还原[13C15N]苯并[b]噻吩-3-碳腈得到[13CD215N]苯并[b]噻吩-3-酰基甲胺稳定同位素标记化合物，具有4个稳定同位素原子^[1]。氘化锂铝也用于新型笼型氧杂环的合成（155mg; 4.08mmol(在干燥THF(20mL)中)和氘标记的脂质氢过氧化氢衍生的双功能亲电试剂4-氧-2(*E*)-烯醛的类似物合成作为氘化物供体^[2,3]。