Martinomycin
(Synonyms: LL-D 37187α) 目录号 : GC45505
A polyether antibiotic
Cas No.:160791-16-2
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Martinomycin is a polyether antibiotic originally isolated from the actinomycete S. salvialis.1,2 It is active against a variety of bacteria, including 11 strains of S. aureus, three strains of S. pneumoniae, and E. faecalis (MICs = 0.12-0.5, 0.06, and 0.5 μg/ml, respectively).2 It induces mortality in 80% of third instar S. eridania larvae when applied at a concentration of 10 ppm to bean leaves.
References
1. Carter, G.T., Schlingmann, G., Kenion, G.B., et al. Martinomycin, a new polyether antibiotic produced by Streptomyces salvialis. II. Isolation and structure determination. J. Antibiot. (Tokyo) 47(12), 1549-1553 (1994).
2. Bernan, V.S., Montenegro, D.A., Goodman, J.J., et al. Martinomycin, a new polyether antibiotic produced by Streptomyces salvialis. I. Taxonomy, fermentation and biological activity. J. Antibiot. (Tokyo) 47(12), 1434-1441 (1994).
| Cas No. | 160791-16-2 | SDF | |
| 别名 | LL-D 37187α | ||
| Canonical SMILES | CC1=C[C@]2([H])[C@](C3(C)C4(OC4)[C@](C[C@H]3OC(/C=C\C=C\C=C\C(O)=O)=O)([H])O2)(C)CC1 | ||
| 分子式 | C49H84O17 | 分子量 | 945.2 |
| 溶解度 | DMSO: soluble,Ethanol: soluble,Methanol: soluble | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 1.058 mL | 5.2899 mL | 10.5798 mL |
| 5 mM | 0.2116 mL | 1.058 mL | 2.116 mL |
| 10 mM | 0.1058 mL | 0.529 mL | 1.058 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Martinomycin, a new polyether antibiotic produced by Streptomyces salvialis. I. Taxonomy, fermentation and biological activity
J Antibiot (Tokyo) 1994 Dec;47(12):1434-41.PMID:7844037DOI:10.7164/antibiotics.47.1434.
Actinomycete culture LL-D37187 has been found to produce the new polyether antibiotic Martinomycin. Taxonomic studies, including morphological, physiological, and cell wall chemistry analyses, revealed that culture LL-D37187 is a novel streptomycete species, and the proposed name is Streptomyces salvialis. Martinomycin exhibits activity against the Southern Army Worm (Spodoptera eridania) and Gram-positive bacteria.