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7-(2,4-Dinitrophenoxy)-4-methyl-2H-chromen-2-one Sale

目录号 : GC45363

A turn-on fluorescent probe for hydrogen sulfide

7-(2,4-Dinitrophenoxy)-4-methyl-2H-chromen-2-one Chemical Structure

Cas No.:314742-00-2

规格 价格 库存 购买数量
1mg
¥428.00
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5mg
¥1,936.00
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10mg
¥3,426.00
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25mg
¥7,504.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

7-(2,4-Dinitrophenoxy)-4-methyl-2H-chromen-2-one is a turn-on fluorescent probe for the detection of hydrogen sulfide (H2S).1 7-(2,4-Dinitrophenoxy)-4-methyl-2H-chromen-2-one undergoes thiolysis by hydrogen sulfide (HS1-). It displays excitation/emission maxima of 323/445 nm, respectively, in DMSO and its fluorescence intensity increases in the presence of sulfur-containing molecules.2,3,1 7-(2,4-Dinitrophenoxy)-4-methyl-2H-chromen-2-one is selective for sulfur-containing molecules, including cysteine, glutathione (GSH), homocysteine, and selenocysteine and is not cytotoxic up to a concentration of 150 μg/ml.1,2

References
1. Chen, Y., Shang, X., Li, C., et al. The synthesis, crystal, hydrogen sulfide detection and cell assement of novel chemsensors based on coumarin derivatives. Sci. Rep. 8(1), 16159 (2018).
2. Zhang, B., Ge, C., Yao, J., et al. Selective selenol fluorescent probes: Design, synthesis, structural determinants, and biological applications. J. Am. Chem. Soc. 137(2), 757-769 (2015).
3. Yang, X.F., Su, Z., Liu, C., et al. A thiol-selective fluorogenic probe based on the cleavage of 4-methylumbelliferyl-2',4',6'-trinitropheyl ether. Anal. Bioanal. Chem. 396(7), 2667-2674 (2010).

Chemical Properties

Cas No. 314742-00-2 SDF
Canonical SMILES CC(C(C=C1)=C(O2)C=C1OC3=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C3)=CC2=O
分子式 C16H10N2O7 分子量 342.3
溶解度 Chloroform: 30mg/mL,DMF: 30mg/mL,DMF:PBS (pH 7.2) (1:2): 0.30mg/mL,DMSO: 5mg/mL 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.9214 mL 14.6071 mL 29.2141 mL
5 mM 0.5843 mL 2.9214 mL 5.8428 mL
10 mM 0.2921 mL 1.4607 mL 2.9214 mL
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