Methyl cellulose
(Synonyms: 甲基纤维素) 目录号 : GC38303
Methyl cellulose 是一种非离子纤维素醚，具有独特的热胶凝性质，没有毒性。
Cas No.:9004-67-5
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Methylcellulose is a natural polymer which gels on heating. Methylcellulose is not toxic.
| Cas No. | 9004-67-5 | SDF | |
| 别名 | 甲基纤维素 | ||
| Canonical SMILES | [Methyl cellulose] | ||
| 分子式 | 分子量 | ||
| 溶解度 | 储存条件 | Store at 4°C | |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
3D Printing Methyl cellulose Hydrogel Wound Dressings with Parameter Exploration Via Computational Fluid Dynamics Simulation
Pharm Res 2022 Feb;39(2):281-294.PMID:35122209DOI:10.1007/s11095-021-03150-5.
Purpose: To investigate and optimize the use of Methyl cellulose in the fabrication of three-dimensional (3D) printed drug-loaded hydrogel wound dressings for the treatment of burns. Method: The effects of incorporating various salts on the properties of Methyl cellulose, especially the gelation temperature was investigated for Methyl cellulose to undergo gelation at skin temperature (i.e., 31.7°C). The optimized Methyl cellulose and salt compositions were then loaded with various drugs beneficial for the treatment of burns. Printability and cumulative release profiles for selected drugs were then obtained, which were then fitted to common release kinetic models. Computational Fluid Dynamics (CFD) simulation was also explored to investigate the relationship between printing parameters and the hydrogel filament produced during extrusion. Results: The printed hydrogels had moderate dimensional integrity, were found to be stable for up to 2 weeks and demonstrated good swelling properties. In vitro drug release studies of various drugs showed that the hydrogel was able to release various drugs within 6 h and release profiles were fitted to common in vitro drug release models, such as the Korsmeyer Peppas model and the Weibull model. While there were deviations from the actual printing process, CFD simulation was able to predict the shape of the printed structure and showed fair accuracy in determining the mass flow rate and line width of extruded hydrogels. Conclusions: Methyl cellulose hydrogels with optimized salt composition demonstrated suitable properties for a wound dressing application, revealing its potential to be used for in situ wound dressing applications.
Hydroxypropyl Methyl cellulose derivatives stabilize fragment antibody against aggregation in spray dried formulations at elevated temperature and resist pH changes
Eur J Pharm Biopharm 2022 Sep;178:105-116.PMID:35917864DOI:10.1016/j.ejpb.2022.07.011.
The ability to deliver stable and active dried protein therapeutics from biopharmaceutical drug delivery systems is critical for solid dosage formulation development. Spray dried formulations with carefully selected excipients provide a unique opportunity in amorphous phase stabilization of the therapeutic proteins. Herein, we discuss the role of hydroxypropyl methylcellulose acetate succinate (HPMCAS) derivatives as polymeric excipients for stabilizing a model fragment antibody (Fab2) during high temperature processing and in possible low pH environments of a drug delivery platform. The effects of high temperature processing and microenvironmental pH sensitivity are of particular interest to us due to their adverse impact on stability of molecules that demonstrate temperature and pH dependent inactivation within drug delivery devices. It appears in solid state at 90 °C and 37 °C and within low pH micro-environment HPMCAS protects protein against aggregation. The high temperature performance of HPMCAS is comparable to that of a disaccharide excipient like trehalose in spray dried protein powder. Simultaneously, inside a poly(lactic-co-glycolic acid) (PLGA) based delivery system HPMCAS provides protection to a pH sensitive protein against acidic degradation products from aqueous hydrolysis of PLGA.
Hyperelastic modeling of solid Methyl cellulose hydrogel under quasi-static compression
J Mech Behav Biomed Mater 2021 Dec;124:104857.PMID:34619636DOI:10.1016/j.jmbbm.2021.104857.
Constitutive modeling of solid Methyl cellulose (MC) hydrogels under quasi-static uniaxial compression is presented for a variety of compositions and test temperatures. Five constitutive models of varying complexity are examined, with the aim to identify the simplest accurate material representation. Due to the viscosity of the gel, the models were calibrated using compression tests only, with restrictions that ensure stability for other loading modes. It is found that of all the tested models, the second order polynomial constitutive model fulfills the requirements of simplicity and accuracy both for compression and predicted tension.
Antioxidant films based on cross-linked Methyl cellulose and native Chilean berry for food packaging applications
Carbohydr Polym 2016 Jan 20;136:1052-60.PMID:26572446DOI:10.1016/j.carbpol.2015.10.013.
Development of antioxidant and antimicrobial active food packaging materials based on biodegradable polymer and natural plant extracts has numerous advantages as reduction of synthetic additives into the food, reduction of plastic waste, and food protection against microorganisms and oxidation reactions. In this way, active films based on methylcellulose (MC) and maqui (Aristotelia chilensis) berry fruit extract, as a source of antioxidants agents, were studied. On the other hand, due to the high water affinity of MC, this polymer was firstly cross-linked with glutaraldehyde (GA) at different concentrations. The results showed that the addition of GA decreased water solubility, swelling, water vapor permeability of MC films, and the release of antioxidant substances from the active materials increased with the concentration of GA. Natural extract and active cross-linked films were characterized in order to obtain the optimal formulation with the highest antioxidant activity and the best physical properties for latter active food packaging application.
Ionic conductive hydroxypropyl Methyl cellulose reinforced hydrogels with extreme stretchability, self-adhesion and anti-freezing ability for highly sensitive skin-like sensors
Int J Biol Macromol 2022 Nov 1;220:90-96.PMID:35970366DOI:10.1016/j.ijbiomac.2022.08.055.
Ionically-conductive hydrogels are attracting increasing interest as skin-like sensors, however, the fabrication of ion-conductive hydrogels with excellent mechanical properties, high conductivity, self-adhesion and anti-freezing ability for high-performance sensors remains a challenge. Herein, a highly ion-conductive hydrogel is prepared by introducing LiCl into polyacrylamide/hydroxypropyl Methyl cellulose (PAM/HPMC) composite hydrogel. The introduction of LiCl simultaneously endows the PAM/HPMC/LiCl hydrogel with outstanding stretchability (1453 %), high tensile strength (135 kPa), skin-like elasticity (9.18 kPa), high conductivity (7.85 S/m), good adhesiveness and wide operating temperature range. Impressively, this ion-conductive hydrogel can be utilized in skin-like sensor, which achieves high strain sensitivity (GF = 11.19) with wide sensing ranges (up to 600 %), and excellent endurance over 250 consecutive stretching. As a result, the wearable sensor assembled from the hydrogels can be used to detect complex human activities with high stability even at -40 °C. This work promotes the development of ion-conductive hydrogels with broad operating temperature in advanced sensory platform.