Flavonol
(Synonyms: 3-羟基黄酮) 目录号 : GC38285
A synthetic flavonol
Cas No.:577-85-5
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
3-Hydroxyflavone is a synthetic flavonol.1 It reduces nicotine-induced cytotoxicity and production of reactive oxygen species (ROS) in NRK-52E cells when used at a concentration of 20 ?M. 3-Hydroxyflavone (30 and 50 ?M) inhibits the motility of U2OS, and the invasiveness of 143B, osteosarcoma cells.2 It reduces tumor growth in a 143B mouse xenograft model when administered at doses of 10 and 20 mg/kg and reduces the formation of pulmonary metastases in a 143B mouse model of metastasis at 20 mg/kg. 3-Hydroxyflavone also reduces acetic acid-induced writhing in mice (ED50 = 55 mg/kg).3
1.Sengupta, B., Sahihi, M., Dehkhodaei, M., et al.Differential roles of 3-hydroxyflavone and 7-hydroxyflavone against nicotine-induced oxidative stress in rat renal proximal tubule cellsPLoS One12(6)e0179777(2014) 2.Lu, K.-H., Chen, P.-N., Hsieh, Y.-H., et al.3-Hydroxyflavone inhibits human osteosarcoma U2OS and 143B cells metastasis by affecting EMT and repressing u-PA/MMP-2 via FAK-Src to MEK/ERK and RhoA/MLC2 pathways and reduces 143B tumor growth in vivoFood Chem. Toxicol.97177-186(2016) 3.Thirugnanasambantham, P., Viswanathan, S., Mythirayee, C., et al.Analgesic activity of certain flavone derivatives: A structure-activity studyJ. Ethnopharmacol.28(2)207-214(1990)
| Cas No. | 577-85-5 | SDF | |
| 别名 | 3-羟基黄酮 | ||
| Canonical SMILES | O=C1C(O)=C(C2=CC=CC=C2)OC3=CC=CC=C13 | ||
| 分子式 | C15H10O3 | 分子量 | 238.24 |
| 溶解度 | Soluble in DMSO | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 4.1974 mL | 20.9872 mL | 41.9745 mL |
| 5 mM | 0.8395 mL | 4.1974 mL | 8.3949 mL |
| 10 mM | 0.4197 mL | 2.0987 mL | 4.1974 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Flavonol intake and stroke risk: a meta-analysis of cohort studies
Nutrition 2014 May;30(5):518-23.PMID:24342529DOI:10.1016/j.nut.2013.10.009.
Objective: Epidemiologic findings are inconsistent regarding the association between Flavonol intake and the risk for stroke. The aim of this study was to determine whether an association exists between them in observational studies. Methods: We searched the PubMed and EMBASE databases for studies conducted from 1966 to August 2013. Prospective cohort studies that provided relative risk (RR) estimates with 95% confidence intervals (CIs) for the association between Flavonol intake and risk for stroke were included. A random effects model was used to combine study-specific risk estimates. Results: The meta-analysis included eight studies, with 5228 stroke cases among 280 174 participants. The summary RR indicated a significant association between highest Flavonol intake and reduced risk for stroke (summary RR, 0.86; 95% CI, 0.75-0.99). Furthermore, an increase in Flavonol intake of 20 mg/d was associated with a 14% decrease in the risk for developing stroke (summary RR, 0.86; 95% CI, 0.77-0.96). Subgroup analyses suggested a significant inverse association between highest Flavonol intake and stroke risk among men (summary RR, 0.74; 95% CI, 0.56-0.97) but not women (summary RR, 0.99; 95% CI, 0.85-1.16). Conclusions: Higher dietary Flavonol intake is associated with a reduced risk for stroke, especially among men. Our results support recommendations for higher consumption of flavonol-rich foods to prevent stroke.
Flavonol-Aluminum Complex Formation: Enhancing Aluminum Accumulation in Tea Plants
J Agric Food Chem 2022 Nov 2;70(43):14096-14108.PMID:36256444DOI:10.1021/acs.jafc.2c04963.
Polyphenol-rich tea plants are aluminum (Al) accumulators. Whether an association exists between polyphenols and Al accumulation in tea plants remains unclear. This study revealed that the accumulation of the total Al and bound Al contents were both higher in tea samples with high Flavonol content than in low, and Al accumulation in tea plants was significantly and positively correlated with their Flavonol content. Furthermore, the capability of flavonols combined with Al was higher than that of epigallocatechin gallate (EGCG) and root proanthocyanidins (PAs) under identical conditions. Flavonol-Al complexes signals (94 ppm) were detected in the tender roots and old leaves of tea plants through solid-state 27Al nuclear magnetic resonance (NMR) imaging, and the strength of the signals in the high Flavonol content tea samples was considerably stronger than that in the low Flavonol content tea samples. This study provides a new perspective for studying Al accumulation in different tea varieties.
Two new Flavonol glycosides from Selaginella tamariscina
J Asian Nat Prod Res 2022 May;24(5):496-502.PMID:34581213DOI:10.1080/10286020.2021.1976160.
Two new Flavonol glycosides 3,5,7-trimethoxyflavone-4'-O-[5'''-O-p-coumaroyl-β-D-apiofuranoyl-(1'''→2'')-β-D-glucopyranoside] (1) and 3,5,7-trimethoxyflavone -4'-O-β-D-glucopyranoside (2) were isolated from Selaginella tamariscina. The structures of 1 and 2 were elucidated on the basis of chemical and spectral analysis, including 1D, 2D NMR analyses and HRESIMS spectrometry. Two compounds were evaluated for cytotoxic activities against A-375, MCF-7, MDA-MB-231 and MDA-MB-468 cell lines by MTT assay. Unfortunately, two compounds displayed no cytotoxic activities.
Fisetin, a Potent Anticancer Flavonol Exhibiting Cytotoxic Activity against Neoplastic Malignant Cells and Cancerous Conditions: A Scoping, Comprehensive Review
Nutrients 2022 Jun 23;14(13):2604.PMID:35807785DOI:10.3390/nu14132604.
Diet plays a crucial role in homeostasis maintenance. Plants and spices containing flavonoids have been widely used in traditional medicine for thousands of years. Flavonols present in our diet may prevent cancer initiation, promotion and progression by modulating important enzymes and receptors in signal transduction pathways related to proliferation, differentiation, apoptosis, inflammation, angiogenesis, metastasis and reversal of multidrug resistance. The anticancer activity of fisetin has been widely documented in numerous in vitro and in vivo studies. This review summarizes the worldwide, evidence-based research on the activity of fisetin toward various types of cancerous conditions, while describing the chemopreventive and therapeutic effects, molecular targets and mechanisms that contribute to the observed anticancer activity of fisetin. In addition, this review synthesized the results from preclinical studies on the use of fisetin as an anticancer agent. Based on the available literature, it might be suggested that fisetin has a bioactive potential to become a complementary drug in the prevention and treatment of cancerous conditions. However, more in-depth research is required to validate current data, so that this compound or its derivatives can enter the clinical trial phase.
Flavonol glycosides from Fissistigma maclurei
J Asian Nat Prod Res 2020 Nov;22(11):1011-1017.PMID:31736359DOI:10.1080/10286020.2019.1671374.
Two new Flavonol glycosides, fissmacosides A (1) and B (2) along with two known Flavonol glycosides, kaempferol 3-O-α-l-rhamnopyranosyl-(1→6)-β-d-galactopyranoside (3) and kaempferol 3-O-β-d-glucopyranosyl-(1→4)-α-l-rhamnopyranosyl-(1→6)-[4-(E)-feruloyl]-β-d-galactopyranoside (4) were isolated from the methanol extract of the leaves of Fissistigma maclurei Merr. Their structures were determined on the basis of extensive spectroscopic methods, including 1D-, 2D-NMR, and MS data.