Multifungin
(Synonyms: 溴柳氯苯胺,Salifungin) 目录号 : GC38164
Salifungin (Multifungin, Bromosalicylchloranilide) is an antifungal and may cause allergic contact dermatitis in some individuals.
Cas No.:3679-64-9
Sample solution is provided at 25 µL, 10mM.
Quality Control & SDS
- View current batch:
- Purity: >99.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Salifungin (Multifungin, Bromosalicylchloranilide) is an antifungal and may cause allergic contact dermatitis in some individuals.
| Cas No. | 3679-64-9 | SDF | |
| 别名 | 溴柳氯苯胺,Salifungin | ||
| Canonical SMILES | O=C(NC1=CC=C(Cl)C=C1)C2=CC(Br)=CC=C2O | ||
| 分子式 | C13H9BrClNO2 | 分子量 | 326.57 |
| 溶解度 | DMSO: 250 mg/mL (765.53 mM) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.0621 mL | 15.3107 mL | 30.6213 mL |
| 5 mM | 0.6124 mL | 3.0621 mL | 6.1243 mL |
| 10 mM | 0.3062 mL | 1.5311 mL | 3.0621 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Schinus molle: a new source of natural fungitoxicant
Appl Environ Microbiol 1986 May;51(5):1085-8.PMID:3729389DOI:10.1128/aem.51.5.1085-1088.1986.
The oil of Schinus molle exhibited the maximum fungitoxic activity during the screening of some essential oils against some common storage and animal pathogenic fungi. It showed absolute toxicity against animal pathogens and mild activity against storage fungi. The effective concentrations of the oil varied from 200 to 900 ppm. The toxicity of the oil persisted up to 80 degrees C and 90 days of storage but declined when autoclaved. It withstood heavy inoculum density. The oil exhibited a narrow range of activity and was found to be more effective than Multifungin, an antifungal drug. The oil was characterized by its various physicochemical properties. It was found to comprise 50 constituents. It appeared that some changes in the oil constituents during storage affected its fungitoxic potency.
Prevalence of Contact Hyper Sensmviw to Common Antiseptics, Antibacterials and Antifungals in Normal Persons
Indian J Dermatol Venereol Leprol 1987 Sep-Oct;53(5):269-272.PMID:28145368doi
Two hundred individuals including 127 apparently normal persons and 73 patients with non-eczematous minor dermatoses were patch tested with 26 commercially available topical antiseptic, anti-bacterial and antifungw preparations. Forty five persons showed 68 positive patch tests, 18 of which were positive for more than one preparation. Males and females showed positive patch test in 23.56 and 83% individuals respectively. Sensitivity to nitrofurazone (furster), benzoic acid, sodium thiosulphate, Multifungin and oxytetracycline (Terramycin) was found in 15 (7.5%), 13 (6.5%). 8 (4%) and 5 (2.5%) persons espectively. The study highlights contact sensitivity to benzoic, sodium thiosulphatc and hamycin for the first time. No person wasn found sensitive to sodium fusidate (Fucidin), gentamicin (Genticyn), toinaftate (Tolnaderm), miconazole (Micogel), clotrimazole (Mycocid), savlon and gentian violet. In view of the possibility of contact sensitivity developing in large number of apparently normal persons (22.50'/o) to a number of commercially available topical preparations, the risk should be weighed against the benefits derived from their use.