Uridine 5'-monophosphate disodium salt
(Synonyms: 尿苷-5'-单磷酸二钠盐) 目录号 : GC37865
A ribonucleotide
Cas No.:3387-36-8
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Uridine-5'-monophosphate is a ribonucleotide.1 It is formed via decarboxylation of orotidine-5'-monophosphate (5'-OMP) by OMP decarboxylase. Uridine-5’-monophosphate is further phosphorylated by uridine-5’-monophosphate-CMP kinase to form UDP and UTP during nucleic acid biosynthesis. Formulations containing uridine-5’-monophosphate have been used as dietary supplements.
1.Berg, J.M., Tymoczko, J.L., and Stryer, L.Nucleotide biosynthesisBiochemistry(2002)
| Cas No. | 3387-36-8 | SDF | |
| 别名 | 尿苷-5'-单磷酸二钠盐 | ||
| Canonical SMILES | O=C(N1)C=CN(C1=O)[C@H]2[C@H](O)[C@H](O)[C@H](O2)COP(O[Na])(O[Na])=O | ||
| 分子式 | C9H11N2Na2O9P | 分子量 | 368.14 |
| 溶解度 | Water: ≥ 50 mg/mL (135.82 mM) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.7164 mL | 13.5818 mL | 27.1636 mL |
| 5 mM | 0.5433 mL | 2.7164 mL | 5.4327 mL |
| 10 mM | 0.2716 mL | 1.3582 mL | 2.7164 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
An Investigation of the Sol-Gel Transition of Chitosan Lactate and Chitosan Chloride Solutions via Rheological and NMR Studies
Gels 2022 Oct 19;8(10):670.PMID:36286171DOI:10.3390/gels8100670.
In recent years, intensive research has been carried out on the use of hydrogels obtained from natural polymers, mainly chitosan. These products are increasingly replacing solutions based on synthetic materials in medicine. This publication presents the results of studies on the sol-gel transition of chitosan solutions as the base material for the preparation of thermosensitive hydrogels for potential applications in tissue engineering. The measurements were carried out for systems consisting of chitosan lactate and chitosan chloride solutions using β-glycerol phosphate disodium salt pentahydrate and Uridine 5'-monophosphate disodium salt as the cross-linking agents. The sol-gel transition point of the solutions was determined based on the rheological measurements in the cone-plate configuration of the rotational rheometer and experiments performed using the method of nuclear magnetic resonance. The obtained results showed a significant influence of the cross-linking agent on the course of the sol-gel transition of chitosan salt solutions, and the systems that consisted of chitosan lactate seemed to be especially interesting for biomedical applications.
Physico-Chemical Properties and Biocompatibility of Thermosensitive Chitosan Lactate and Chitosan Chloride Hydrogels Developed for Tissue Engineering Application
J Funct Biomater 2021 May 20;12(2):37.PMID:34065271DOI:10.3390/jfb12020037.
Recently, the modification of the initial structure of biopolymers, mainly chitosan, has been gaining importance with a view to obtain functional forms with increased practicality and specific properties enabling their use in tissue engineering. Therefore, in this article, the properties (structural and biological) of thermosensitive hydrogels obtained from chitosan lactate/chloride and two types of crosslinking agents (β-glycerol phosphate disodium salt pentahydrate and Uridine 5'-monophosphate disodium salt) are discussed. The aim of the research is to identify changes in the structure of the biomaterials during conditioning in water. Structural investigations were carried out by FTIR spectroscopy. The crystallinity of gels was determined by X-ray diffraction analysis. The biocompatibility (evaluation of cytotoxicity and genotoxicity) of chitosan hydrogels was investigated by contact with human colon adenocarcinoma cell line for 48 h. The cytotoxicity was verified based on the colorimetric resazurin assay, and the genotoxicity was checked by the comet assay (percentage of DNA in the comet tail). The conducted research showed that the analyzed types of chitosan hydrogels are non-cytotoxic and non-genotoxic materials. The good biocompatibility of chitosan hydrogels surfaces makes them interesting scaffolds with clinical potential in tissue regeneration engineering.