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TH287 hydrochloride Sale

目录号 : GC37775

A selective MTH1 inhibitor

TH287 hydrochloride Chemical Structure

Cas No.:1638211-05-8

规格 价格 库存 购买数量
5mg
¥675.00
现货
10mg
¥918.00
现货
50mg
¥3,645.00
现货
100mg
¥5,850.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

Human mutT homolog (MTH1) is a nucleotide pool sanitizing enzyme that cleaves oxidized nucleotides (dNTPs) to prevent incorporation of damaged bases during DNA replication. Cancer cells rely on MTH1 activity in order to avoid cell death. TH287 is an MTH1 inhibitor (IC50 = 0.8 nM) that selectively kills cancer cell lines (IC50s = 0.8-3.06 ?M) without significant cytotoxicity towards primary or immortalized cells (IC50s = ≥20 ?M).1 At up to 100 ?M it does not show significant effect towards the related nudix hydrolase protein family members MTH2, NUDT5, NUDT12, NUDT14, and NUDT16, as well as other proteins with known nucleoside triphosphate pyrophosphatase activity (dCTPase, dUTPase, and ITPA).1

1.Gad, H., Koolmeister, T., Jemth, A.S., et al.MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP poolNature508215-242(2014)

Chemical Properties

Cas No. 1638211-05-8 SDF
Canonical SMILES NC1=NC(C2=CC=CC(Cl)=C2Cl)=CC(NC)=N1.[H]Cl
分子式 C11H11Cl3N4 分子量 305.59
溶解度 Soluble in DMSO 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 3.2724 mL 16.3618 mL 32.7236 mL
5 mM 0.6545 mL 3.2724 mL 6.5447 mL
10 mM 0.3272 mL 1.6362 mL 3.2724 mL
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