Leucokinin VIII
(Synonyms: Leucokinin 8) 目录号 : GC36440
Leucokinin VIII 是一种利尿八肽，从蟑螂头部提取物中得到。
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Leucokinin VIII is an diuretic octapeptide isolated form head extracts of the cockroach.
Leucokinin VIII is an octapeptide, increases the rates of transepithelial NaC1, KC1 and water secretion, increases the Cl conductance of the epithelial shunt via a receptor located at the basolateral side of the epithelium[1]. Leucokinin VIII also activates Ca2+-dependent signal pathway in principal cells of Aedes aegyptiMalpighian tubules[2].
[1]. Pannabecker TL, et al. Regulation of epithelial shunt conductance by the peptide leucokinin. J Membr Biol. 1993 Feb;132(1):63-76. [2]. Yu MJ, et al. Leucokinin activates Ca(2+)-dependent signal pathway in principal cells of Aedes aegypti Malpighian tubules. Am J Physiol Renal Physiol. 2002 Sep;283(3):F499-508.
| Cas No. | SDF | ||
| 别名 | Leucokinin 8 | ||
| 分子式 | C42H52N10O11 | 分子量 | 872.92 |
| 溶解度 | Soluble in DMSO | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.1456 mL | 5.7279 mL | 11.4558 mL |
| 5 mM | 0.2291 mL | 1.1456 mL | 2.2912 mL |
| 10 mM | 0.1146 mL | 0.5728 mL | 1.1456 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Localization of Leucokinin VIII in the cockroach, Leucophaea maderae, using an antiserum directed against an achetakinin-I analog
Neurochem Res 1994 Jul;19(7):805-14.PMID:7969749DOI:10.1007/BF00967448.
An antiserum against an achetakinin analog selectively localized Leucokinin VIII (LKVIII) in the CNS of Leucophaea maderae. Preabsorption studies of the achetakinin antiserum with either preimmune serum or LKVIII prevented a positive reaction in both ELISA and immunocytochemical procedures. LKVIII immunoreactive neurons were found in the brain, frontal, and subesophageal ganglion, all 3 thoracic ganglia and the terminal ganglion. Nerves originating from the thoracic and terminal abdominal ganglia contain LKVIII material. Lateral and medial neurosecretory cells synthesizing LKVIII-like products contribute axons to the nervi corporis cardiaci that terminate in neurohemal sites in the corpora cardiaca and nervi corporis allati. Thus, Leucokinin VIII, like leucokinin I (LKI) and leucomyosuppressin (LMS), appears to have both a neurohemal and neurotransmitter mode of regulating target cells in L. maderae.