Danshenxinkun B
(Synonyms: 丹参新醌乙) 目录号 : GC35808
Danshenxinkun B 是存在于tanshen (Salvia miltiorhiza Bung) 中的一种抗氧化活性成分。
Cas No.:65907-76-8
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Danshenxinkun B is an antioxidative component of tanshen (Salvia miltiorhiza Bung) [1].
[1]. Zhang, K, et al. Antioxidative components of tanshen (Salvia miltiorhiza Bung). Journal of Agricultural and Food Chemistry, 38(5), 1194-1197.
| Cas No. | 65907-76-8 | SDF | |
| 别名 | 丹参新醌乙 | ||
| Canonical SMILES | O=C1C(C(C)C)=C(O)C(C2=C1C=CC3=C2C=CC=C3C)=O | ||
| 分子式 | C18H16O3 | 分子量 | 280.32 |
| 溶解度 | Soluble in DMSO | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.5674 mL | 17.8368 mL | 35.6735 mL |
| 5 mM | 0.7135 mL | 3.5674 mL | 7.1347 mL |
| 10 mM | 0.3567 mL | 1.7837 mL | 3.5674 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
[Chemical Constituents from Salvia przewalskii Root]
Zhong Yao Cai 2015 Jun;38(6):1197-201.PMID:26762059doi
Objective: To study the chemical constituents of the root of Salvia przewalakii. Methods: The chemical constituents were isolated and purified by means of chromatographic techniques and their structures were elucidated by spectroscopic methods. Results: 17 compounds were isolated and identified as Danshenxinkun B (1), danshenol C (2), isotanshinone (3), 1,2-dihydroisodihydrotanshinone-I (4), isotanshinone-II A (5), dihydrotanshinone-I (6), tanshinlactone (7), danshenol B (8), tanshinone-I (9), danshenspiroketallactone (10), ferrugino (11), epi-danshenspiroketallactone (12), danshenxinkun A (13), sapriolactone (14), 12-hydroxy-6,7-secoabieta-8,11,13-trien-6,7-diol (15), 6α-hydroxysugiol (16) and hypargenin B (17). Conclusion: Compounds 1 - 8 are isolated from this plant for the first time.
Preparative isolation and purification of six diterpenoids from the Chinese medicinal plant Salvia miltiorrhiza by high-speed counter-current chromatography
J Chromatogr A 2001 Aug 3;925(1-2):109-14.PMID:11519796DOI:10.1016/s0021-9673(01)01026-3.
A high-speed counter-current chromatography (HSCCC) method was developed for the preparative separation and purification of six diterpenoids. dihydrotanshinone I, cryptotanshinone, methylenetanshiquinone, tanshinone I, tanshinone IIA and Danshenxinkun B from the Chinese medicinal plant Salvia miltiorrhiza Bunge. The crude diterpenoids were obtained by extraction with ethanol-n-hexane (1:1, v/v) from S. miltiorrhiza Bunge. Preparative HSCCC with the two-phase solvent systems A composed of n-hexane-ethanol-water (10:5.5:4.5, v/v) and B composed of n-hexane-ethanol-water (10:7:3, v/v) was successfully performed in a stepwise elution yielding six relatively pure diterpenoids from 300 mg of the crude extract in a single run. The purities of dihydrotanshinone I, cryptotanshinone, methylenetanshiquinone, tanshinone I, tanshinone IIA and Danshenxinkun B were 88.1, 98.8, 97.6, 93.5, 96.8 and 94.3%, respectively.
[Chemical constituents of tissue cultures of Salvia miltiorrhiza Bunge]
Zhongguo Zhong Yao Za Zhi 1998 Mar;23(3):166-7, 192.PMID:11596236doi
Two compounds were isolated from the tissue cultures of Salvia miltiorrhiza for the first time, and identified as Danshenxinkun B and Ro-09-0680 by spectroscopic methods.