5-Methylfurfural
(Synonyms: 5-甲基呋喃醛) 目录号 : GC35167
5-Methyl furfural is an important chemical intermediate.
Cas No.:620-02-0
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
5-Methyl furfural is an important chemical intermediate.
| Cas No. | 620-02-0 | SDF | |
| 别名 | 5-甲基呋喃醛 | ||
| Canonical SMILES | O=CC1=CC=C(C)O1 | ||
| 分子式 | C6H6O2 | 分子量 | 110.11 |
| 溶解度 | Soluble in DMSO | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 9.0818 mL | 45.4091 mL | 90.8183 mL |
| 5 mM | 1.8164 mL | 9.0818 mL | 18.1637 mL |
| 10 mM | 0.9082 mL | 4.5409 mL | 9.0818 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Direct Synthesis of 5-Methylfurfural from d-Fructose by Iodide-Mediated Transfer Hydrogenation
ChemSusChem 2021 Dec 6;14(23):5311-5319.PMID:34612600DOI:10.1002/cssc.202102021.
Herein, a robust catalytic system was developed for the green synthesis of 5-Methylfurfural (5-MF) by iodide-mediated transfer hydrogenation. Around 50 % of 5-MF was yielded from d-fructose within 7.5 min using NaI as the catalyst and formic acid as both the hydrogen source and co-catalyst. The catalytic system was used for six consecutive cycles without any decrease in the yield. Various starch and raw biomass could be used as promising starting materials for 5-MF synthesis with moderate yields, and the productivity of 5-MF from corn starch reached 103 mmol gcat -1 h-1 , which is comparable with the best result from l-rhamnose. Moreover, the co-production of 5-MF and furfural from raw biomass makes this methodology more competitive than other routes.
Formation of 5-Methylfurfural and 2-acetylfuran from lignocellulosic biomass and by Cr3+-catalyzed dehydration of 6-deoxyhexoses
Carbohydr Res 2022 Dec;522:108672.PMID:36183617DOI:10.1016/j.carres.2022.108672.
During autocatalyzed steam explosion of lignocellulose, polysaccharides in the cell wall are hydrolyzed and dehydrated to form various furaldehydes. In addition to furfural, 5-Methylfurfural and 2-acetylfuran were identified in condensates from autocatalyzed steam explosion of Scandinavian softwood (Norway spruce, Picea abies). The presence of 5-Methylfurfural can be explained by an acid-catalyzed dehydration of 6-deoxyaldohexoses, which are known to be present in lignocellulosic biomass. However, the presence of 2-acetylfuran cannot be explained by previously published reaction mechanisms since the required substrate (a 1-deoxyhexose or a 1-deoxyhexosan) is not known to be present in lignocellulosic biomass. In model experiments, it was shown that 2-acetylfuran is formed from rhamnose and fucose upon heating in the presence of the Lewis acid Cr3+. Possible reaction pathways for the formation of 2-acetylfuran from 6-deoxyaldohexoses are suggested. This reaction can potentially enable the targeted production of 2-acetylfuran from renewable biomass feedstocks.
Selective hydrogenation of 5-(hydroxymethyl)furfural to 5-Methylfurfural over single atomic metals anchored on Nb2O5
Nat Commun 2021 Jan 26;12(1):584.PMID:33500400DOI:10.1038/s41467-020-20878-7.
5-Methylfurfural (MF) is a very useful chemical. Selective hydrogenation of biomass platform molecule 5-(hydroxymethyl)furfural (HMF) to MF using H2 as the reducing agent is very attractive, but challenging because hydrogenation of C=O bond in HMF is more favourable than C-OH both kinetically and thermodynamically, and this route has not been realized. In this work, we prepare isolated single atomic catalysts (SACs) Pt1/Nb2O5-Ov, Pd1/Nb2O5-Ov, and Au1/Nb2O5-Ov, in which single metal atoms are supported on oxygen defective Nb2O5 (Nb2O5-Ov). It is discovered that the SACs can efficiently catalyze the hydrogenation of HMF to MF using H2 as the reducing agent with MF selectivity of >99% at complete conversion, while the selectivities of the metal nanocatalysts supported on Nb2O5 are very poor. A combination of experimental and density function theory (DFT) studies show that the unique features of the SACs for the reaction result from the cooperation of the Nb and Pt sites near the interface in the Pt1/Nb2O5-Ov. The Pt atoms are responsible for the activation of H2 and the Nb sites activate C-OH in the reaction. This work opens the way for producing MF by direct hydrogenation of biomass-derived HMF using H2 as the reductant.
Towards Improved Biorefinery Technologies: 5-Methylfurfural as a Versatile C6 Platform for Biofuels Development
ChemSusChem 2019 Jan 10;12(1):185-189.PMID:30315683DOI:10.1002/cssc.201802126.
Low chemical stability and high oxygen content limit utilization of the bio-based platform chemical 5-(hydroxymethyl)furfural (HMF) in biofuels development. In this work, Lewis-acid-catalyzed conversion of renewable 6-deoxy sugars leading to formation of more stable 5-Methylfurfural (MF) is carried out with high selectivity. Besides its higher stability, MF is a deoxygenated analogue of HMF with increased C/O ratio. A highly selective synthesis of the innovative liquid biofuel 2,5-dimethylfuran starting from MF under mild conditions is described. The superior synthetic utility of MF against HMF in benzoin and aldol condensation reactions leading to long-chain alkane precursors is demonstrated.
Investigation of the Hydrogenation of 5-Methylfurfural by Noble Metal Nanoparticles in a Microcapillary Reactor
ChemSusChem 2016 Mar 21;9(6):583-7.PMID:26871887DOI:10.1002/cssc.201600045.
On-column reaction gas chromatography (ocRGC) was successfully utilized as high-throughput platform for monitoring of the conversion and selectivity of hydrogenation of 5-Methylfurfural catalyzed by polymer-stabilized Ru and Pd nanoparticles. We were able to elucidate the effect of various reaction conditions, mainly together with the catalyst loading on the conversion rate and the selectivity of the reaction. Our strategy yields significant improvements in reaction analysis times and cost effectiveness in comparison to standard methods. We are able to demonstrate that ocRGC approach provides valuable information about the reaction system that gives scientists a tool to design suitable catalytic systems for enhanced sustainable chemistry in the future.