Fumitremorgin B |
| 目录号 GC47377 |
Sample solution is provided at 25 µL, 10mM.
Quality Control & SDS
- View current batch:
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Purity: >95.00%
- COA (Certificate Of Analysis)
- Datasheet
Fumitremorgin B is a mycotoxin originally isolated from A. fumigatus.1,2 It induces tremors in and is lethal to mice (LD50 = 5.4 mg/kg, i.v.). It is also toxic to brine shrimp (LC50 = 13.6 μg/ml).3 Fumitremorgin B is active against the phytopathogenic fungi B. cinerea, A. solani, A. alternata, C. gloeosporioides, F. solani, F. oxysporum, and G. saubinettii (MICs = 6.25-100 μg/ml). It has antifeedant activity against armyworm (M. separata) larvae when applied to fresh wheat leaves. Fumitremorgin B inhibits the proliferation of U937 and PC3 cells (IC50s = 14.12 and 43.36 μM, respectively).4
1.Yamazaki, M., Suzuki, S., and Miyaki, K.Tremorgenic toxins from Aspergillus fumigatus FresChem. Pharm. Bull. (Tokyo)19(8)1739-1740(1971) 2.Yamazaki, M., and Suzuki, S.Toxicology of tremorgenic mycotoxins, fumitremorgin A and BDev. Toxicol. Environ. Sci.12273-282(1986) 3.Li, X.-J., Zhang, Q., Zhang, A.-L., et al.Metabolites from Aspergillus fumigatus, an endophytic fungus associated with Melia azedarach, and their antifungal, antifeedant, and toxic activitiesJ. Agric. Food Chem.60(13)3424-3431(2012) 4.Wang, Y., Li, Z.-L., Bai, J., et al.2,5-diketopiperazines from the marine-derived fungus Aspergillus fumigatus YK-7Chem. Biodivers.9(2)85-93(2012)
| Cas No. | 12626-17-4 | SDF | |
| 别名 | N/A | ||
| 化学名 | N/A | ||
| Canonical SMILES | COC1=CC=C(C(N2C/C=C(C)\C)=C1)C3=C2[C@H](/C=C(C)\C)N(C([C@@]4([H])N5CCC4)=O)[C@]([C@H]3O)(O)C5=O | ||
| 分子式 | C27H33N3O5 | 分子量 | 479.6 |
| 溶解度 | DMSO: Soluble,Methanol: Soluble | 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. | ||
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
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| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % ddH2O | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH2O，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。