Fucoidan
(Synonyms: 岩藻多糖；褐藻糖胶) 目录号 : GC16236
A sulfated polysaccharide with diverse biological activities
Cas No.:9072-19-9
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Fucoidan, a type of complex carbohydrate called a polysaccrharide, is found in many forms of brown seaweed. Fucoidan has a variety of biological activities, including anticancer, antiviral, neuroprotective, and immune-modulating effects. It has been reported that fucoidan enhances the activities of natural killer (NK) cells which play a vital role in anti-cancer activity.
In vitro: Fucoidan triggered apoptosis of PC-3 cells, human prostate cancer cells, via evoking intrinsic and extrinsic signaling pathways in a dose-dependent fashion, which indicated that fucoidan could dose-dependently block the growth of PC-3 cells. The activation of apoptosis induced by fucoidan was involved in the inactivation of p38 MAPK and phosphatidylinositol 3-kinase (PI3K) /Akt, and the activation of extracellular signal-regulated kinase mitogen-activated protein kinase (ERK1/2 MAPK) [1].
In vivo: Female Balb/c mice bearing breast cancer were intraperitoneally injected with fucoidan at 10 mg/kg body weight every two days for 20 days. Fucoidan decreased the tumor volume and the tumor weight in Balb/c mice. Additionally, fucoidan triggered apoptosis, which indicated that fucoidan could exert a strong antitumor effect on breast cancer model. Compared with control group, fucoidan dampened angiogenesis in tumor tissue via inducing a remarkable decrease in intratumoral vascular endothelial growth factor expression and inhibited lung metastasis of breast cancer [2].
References:
[1]. Boo, H., Hong, J., Kim, S., Kang, J., Kim, M., & Kim, E. et al. The Anticancer Effect of Fucoidan in PC-3 Prostate Cancer Cells. Marine Drugs. 2013; 11(8): 2982-2999.
[2]. Xue, M., Ge, Y., Zhang, J., Wang, Q., Hou, L., & Liu, Y. et al. Anticancer Properties and Mechanisms of Fucoidan on Mouse Breast Cancer In Vitro and In Vivo. Plos ONE. 2012; 7(8). e43483.
| Cas No. | 9072-19-9 | SDF | |
| 别名 | 岩藻多糖；褐藻糖胶 | ||
| 化学名 | (2S,3S,4S,5S,6R)-4-hydroxy-5-methoxy-2,6-dimethyltetrahydro-2H-pyran-3-yl hydrogen sulfate | ||
| Canonical SMILES | C[C@]1([H])[C@@H](OC)[C@H](O)[C@H](OS(O)(=O)=O)[C@H](C)O1 | ||
| 分子式 | (C6H9O3SO3)n | 分子量 | 242.24 |
| 溶解度 | Water: 4.8mg/ml | 储存条件 | Store at RT |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 4.1281 mL | 20.6407 mL | 41.2814 mL |
| 5 mM | 0.8256 mL | 4.1281 mL | 8.2563 mL |
| 10 mM | 0.4128 mL | 2.0641 mL | 4.1281 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。