Fluazinam
(Synonyms: 氟啶胺) 目录号 : GC32346
A fungicide
Cas No.:79622-59-6
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Fluazinam is a fungicide.1 It inhibits mycelial growth of 35 plant pathogenic fungi, including S. sclerotiorum, P. infestans, C. rolfsii, B. cinerea, and Fusarium (EC50s = <0.1-42.1 ppm). Fluazinam (0.56 kg/ha) reduces the incidence of Sclerotinia blight in peanut fields.2 It decreases the incidence of leaf drop in lettuce fields experimentally infected with S. minor or S. sclerotiorum when applied at a concentration of 561 g AI/ha. Formulations containing fluazinam have been used as fungicides in agriculture.
1.Komyoji, T., Sugimoto, K., Mitani, S., et al.Biological properties of a new fungicide, fluazinamJ. Pesticide Sci.20(2)129-135(1995) 2.Smith, F.D., Phipps, P.M., and Stipes, R.J.Fluazinam: A new fungicide for control of Sclerotinia blight and other soilborne pathogens of peanutPeanut Sci.19(2)115-120(1992)
| Cas No. | 79622-59-6 | SDF | |
| 别名 | 氟啶胺 | ||
| Canonical SMILES | FC(C1=CN=C(NC2=C([N+]([O-])=O)C=C(C(F)(F)F)C(Cl)=C2[N+]([O-])=O)C(Cl)=C1)(F)F | ||
| 分子式 | C13H4Cl2F6N4O4 | 分子量 | 465.09 |
| 溶解度 | DMSO : 125 mg/mL (268.77 mM) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.1501 mL | 10.7506 mL | 21.5012 mL |
| 5 mM | 0.43 mL | 2.1501 mL | 4.3002 mL |
| 10 mM | 0.215 mL | 1.0751 mL | 2.1501 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Fluazinam
Acta Crystallogr Sect E Struct Rep Online 2013 Aug 23;69(Pt 9):o1467.PMID:24427089DOI:10.1107/S1600536813023210.
In the asymmetric unit of the title compound {systematic name: 3-chloro-N-[3-chloro-5-(tri-fluoro-meth-yl)pyridin-2-yl]-2,6-di-nitro-4-(tri-fluoro-methyl)-aniline}, C13H4Cl2F6N4O4, which is the fungicide Fluazinam, the dihedral angle between the pyridine and benzene ring planes is 42.20 (4)掳. In the crystal, pairs of N-H鈰疐 hydrogen bonds link the mol-ecules into inversion dimers which are linked by C-Cl鈰€ [Cl鈰痳ing centroid = 3.3618 (4) A 掳] and N-O鈰€ [O鈰痳ing centroid = 3.1885 (16) 脜] inter-actions into chains along [100]. In addition, short Cl鈰疌l, O鈰疌l, and F鈰疐 contacts [3.4676 (7), 3.2371 (13) and 2.7910 (15) 脜] are present which connect the chains, yielding a three-dimensional network.
Activity and cell toxicology of Fluazinam on Fusarium graminearum
Pestic Biochem Physiol 2022 Nov;188:105253.PMID:36464359DOI:10.1016/j.pestbp.2022.105253.
Fusarium graminearum is an important plant pathogen and the causal agent of Fusarium head blight (FHB). At present, the principal method of controlling FHB is through fungicides. Fluazinam is an agent with strong broad-spectrum antifungal activity and has been used to control many diseases. However, there are no reported uses of Fluazinam for controlling FHB. This study reports the activity and cell toxicology mechanisms of Fluazinam on the filamentous fungus F. graminearum and its effect on fungal growth and development. The activity of Fluazinam was tested for 95 wild-type field strains of F. graminearum. The EC50 values (the 50% effective concentration) of Fluazinam for inhibition of mycelial growth and spore germination ranged from 0.037 渭g/ml to 0.179 渭g/ml and from 0.039 渭g/ml to 0.506 渭g/ml, respectively. The Fluazinam sensitivity of these strains varied in 4.9 and 13.0 folds, implying that the target of the fungicide remained unchanged. After treatment with 0.3 渭g/ml (鈮圗C90) Fluazinam, the production of conidia was reduced, and the cell wall and cell membrane had shrunked; the cell nucleus and septum morphology, cell membrane permeability, and sexual development were not affected. When treated with 0.1 渭g/ml (鈮圗C50) or 0.3 渭g/ml Fluazinam, the mycelial respiration and deoxynivalenol (DON) synthesis of F. graminearum were decreased. Confocal images showed that the formation of toxisomes was disturbed after Fluazinam treatment, suggesting that Fluazinam reduces DON synthesis by inhibiting toxisome formation. Infection of wheat coleoptiles revealed that Fluazinam had a strong protective activity against F. graminearum. At 250 渭g/ml Fluazinam the control efficacy of protective treatments reached 100% and controlled strains resistant to carbendazim. These results contribute to the understanding of the mode of action of Fluazinam and its application.
Persistence of Fluazinam in soil under boreal conditions
J Environ Sci Health B 2020;55(6):539-549.PMID:32090662DOI:10.1080/03601234.2020.1729631.
Fluazinam, a widely used pesticide in conventional potato cultivation, is effective against epidemics of the fungal disease late blight. To assess Fluazinam persistence in soil, laboratory experiments were conducted with Fluazinam added to soil as a pure chemical or contained in the commercial product Shirlan庐. In a follow-up experiment, the persistence was monitored under constant temperature and water content conditions during a maximum period of 1 year. In an annual climatic rotation experiment, Fluazinam added to soil was exposed to the year-round temperature and water content conditions occurring in the boreal zone. A third experiment was undertaken to clarify the effect of soil organic matter (SOM) on the recovery of Fluazinam. In the follow-up and annual climatic rotation experiments, more than half of the added Fluazinam was recovered after 1 year of incubation. The estimated half-life of Fluazinam ranged between 355 and 833 days. The degradation of Fluazinam was enhanced by an abundance of SOM, a warm temperature, and wetness. Additionally, in over half of soil samples collected from fields where potato had been intensively cultivated for many years, varying concentrations of Fluazinam were detected. Fluazinam can carry over to the next growing season in professional potato production.
Encapsulation of Fluazinam to extend efficacy duration in controlling Botrytis cinerea on cucumber
Pest Manag Sci 2021 Jun;77(6):2836-2842.PMID:33538400DOI:10.1002/ps.6318.
Background: Fluazinam is an effective fungicide in controlling gray mold, but has short duration of efficacy. Increasing application dosage may cause phytotoxicity. To overcome this shortage, a controlled-release technology was studied by encapsulating Fluazinam. Ethyl cellulose polymer microcapsules were loaded with Fluazinam to formulate a Fluazinam capsule suspension (FCS). The efficacy for inhibition of B. cinerea and persistency of the FCS were examined by comparing with Fluazinam technical concentrate (FTC) and aqueous Fluazinam suspension concentrate (FSC) using microscopic observation and high-performance liquid chromatography analysis. Results: FCS formed capsules, with median size of 3.17 渭m in diameter, had 82.3% encapsulation efficiency. It had a stronger inhibitory activity against B. cinerea than FTC and FSC measured 7 days after the treatments. The half-life of FCS on cucumber leaves was 3.4 days, longer than the 2.3 days of FSC. Conclusion: FCS formulation significantly improved the inhibition of B. cinerea and resulted in prolonged and sustained release. Moreover, microencapsulation increased the duration of the efficacy of Fluazinam on target crops. This formulation could help to sustain pesticides and protect the environment. 漏 2021 Society of Chemical Industry.
Impact of Fluazinam on morphological and physiological characteristics of Sclerotinia sclerotiorum
Pestic Biochem Physiol 2019 Mar;155:81-89.PMID:30857631DOI:10.1016/j.pestbp.2019.01.009.
Sclerotinia sclerotiorum is a necrotrophic and filamentous fungus with a broad host range. Fluazinam is a pyridinamine fungicide with a broad spectrum of antifungal activity and had a strong inhibition effect on mycelial growth of S. sclerotiorum populations. But the impact of Fluazinam on morphological and physiological characteristics of S. sclerotiorum is little known. In this study, the EC50 values of Fluazinam to three strains of S. sclerotiorum (CZ17S, YZ55S and SA42S) were 0.0084, 0.007, 0.0065 渭g/ml respectively. After Fluazinam treatment, hyphae of S. sclerotiorum became thinner, hyphal offshoot of top increased, the distance between one septum and another became shorter, cell membrane permeability increased markedly, exopolysaccharide (EPS) content and oxalic acid content decreased significantly, peroxidase (POD) activity increased significantly and mycelial respiration was inhibited. While the number and dry weight of sclerotia, glycerol content in the mycelia did not significantly change. In protective activity assay on detached rapeseed leaves, application of Fluazinam at 40 渭g/ml and 80 渭g/ml, the control efficacy reached to 41.4% and 100%, respectively. In curative activity assay, application of Fluazinam at 100 渭g/ml, the control efficacy reached to 61.09%. In the same concentration, protective activity of Fluazinam against S. sclerotiorum was higher than curative activity. These results will contribute to us on evaluating the potential of the fungicide Fluazinam for management of Sclerotinia stem rot and understanding the mode of action of Fluazinam against S. sclerotiorum.