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Fleroxacin Sale

(Synonyms: 氟罗沙星; RO 23-6240; AM-833) 目录号 : GC10361

A fluoroquinolone antibiotic

Fleroxacin Chemical Structure

Cas No.:79660-72-3

规格 价格 库存 购买数量
500 mg
¥360.00
现货
1 g
¥576.00
现货
5 g
¥837.00
现货
10 g
¥1,507.00
现货

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Sample solution is provided at 25 µL, 10mM.

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产品描述

Fleroxacin (RO 23-6240) is a broad-spectrum antimicrobial fluoroquinolone.

Fleroxacin (Ro 23-6240) is a new trifluorinated quinolone exhibiting high activity against a broad spectrum of gram-negative and gram-positive bacteria. Fleroxacin is characterized pharmacokinetically by a long elimination half-life (9 to 10 h) and high concentrations in plasma (e.g., maximum concentration of 2.3 micrograms/ml after an oral dose of 200 mg)[1]. Fleroxacin (Ro 23-6240) is effective against Haemophilus ducreyi in vitro. Fleroxacin (Ro 23-6240), 200 or 400 mg as a single oral dose, is efficacious therapy for microbiologically proven chancroid in patients who do not have concurrent HIV-1 infection. Among HIV-1-infected men, a single dose of 200 or 400 mg of fleroxacin is inadequate therapy for chancroid[2][3].

References:
[1]. Weidekamm, E., et al., Single- and multiple-dose pharmacokinetics of fleroxacin, a trifluorinated quinolone, in humans. Antimicrob Agents Chemother, 1987. 31(12): p. 1909-14.
[2]. MacDonald, K.S., et al., Evaluation of fleroxacin (RO 23-6240) as single-oral-dose therapy of culture-proven chancroid in Nairobi, Kenya. Antimicrob Agents Chemother, 1989. 33(5): p. 612-4.
[3]. Rubinstein, E., History of quinolones and their side effects. Chemotherapy, 2001. 47 Suppl 3: p. 3-8; discussion 44-8.

Chemical Properties

Cas No. 79660-72-3 SDF
别名 氟罗沙星; RO 23-6240; AM-833
化学名 6,8-difluoro-1-(2-fluoroethyl)-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid
Canonical SMILES CN1CCN(CC1)C2=C(C=C3C(=C2F)N(C=C(C3=O)C(=O)O)CCF)F
分子式 C17H18F3N3O3 分子量 369.34
溶解度 DMF: 0.1 mg/ml,DMSO: 15 mg/ml,PBS (pH 7.2): 10 mg/ml 储存条件 4°C, protect from light
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.7075 mL 13.5377 mL 27.0753 mL
5 mM 0.5415 mL 2.7075 mL 5.4151 mL
10 mM 0.2708 mL 1.3538 mL 2.7075 mL
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